World Journal of Microbiology and Biotechnology, Год журнала: 2025, Номер 41(6)
Опубликована: Июнь 1, 2025
Язык: Английский
Nanomaterials, Год журнала: 2025, Номер 15(3), С. 158 - 158
Опубликована: Янв. 21, 2025
Active cancer targeting consists of the selective recognition overexpressed biomarkers on cell surfaces or within tumor microenvironment, enabled by ligands conjugated to drug carriers. Nanoparticle (NP)-based systems are highly relevant for such an approach due their large surface area which is amenable a variety chemical modifications. Over past decades, several studies have debated efficiency passive targeting, highlighting active as more specific and approach. The choice conjugation chemistry attaching nanocarriers critical ensure stable robust system. Among panel biomarkers, epidermal growth factor receptor (EGFR) stands one most frequently receptors in different types. design development with surface-bound anti-EGFR vital targeted therapy, relying facilitated capture EGFR-overexpressing cells enabling receptor-mediated endocytosis improve accumulation microenvironment. In this review, we examine examples recent significant explore various strategies NP functionalization biomolecules small molecular ligands. addition, also describe some common characterization techniques confirm analyze patterns.
Язык: Английский
Процитировано
3
Bioanalysis, Год журнала: 2025, Номер unknown, С. 1 - 16
Опубликована: Фев. 3, 2025
Undruggable targets account for roughly 85% of human disease-related and represent a category therapeutic that are difficult to tackle with traditional methods, but their considerable clinical importance. These generally defined by planar functional interfaces the absence efficient ligand-binding pockets, making them unattainable conventional pharmaceutical strategies. The advent oligonucleotide-based proteolysis-targeting chimeras (PROTACs) has instilled renewed optimism in addressing these challenges. PROTACs facilitate targeted degradation undruggable entities, including transcription factors (TFs) RNA-binding proteins (RBPs), via proteasome-dependent mechanisms, thereby presenting novel approaches diseases linked targets. This review offers an in-depth examination recent progress integration PROTAC technology oligonucleotides target traditionally proteins, emphasizing design principles mechanisms action innovative PROTACs.
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 394 - 394
Опубликована: Март 20, 2025
In addition to classic small-molecule drugs and modern protein-based biologics, an intriguing class of medicines is the therapeutic oligonucleotides. Most approved in this category are antisense oligomers or those acting via RNA interference, both which use base hybridization. Aptamers, also known as chemical antibodies form a smaller, yet equally interesting group oligonucleotides that can recognize wide range molecular targets. Despite their high potential, only two aptamers have been date, pegaptanib (MacugenTM) avacincaptad pegol (IzervayTM), for treatment age-related macular degeneration (AMD). Targeting vascular endothelial growth factor (VEGF), plays important role pathogenesis many eye diseases, emerged first anti-VEGF agent was used various indications, further inspiring development other therapies. review, we summarize history aptamer medicine, pegaptanib. We describe its chemistry track from earliest stages preclinical phase, clinical trials, eventual regulatory approval. Additionally, evaluate position among agents provide comprehensive overview pegaptanib’s efficacy, safety, cost-effectiveness, comparing these aspects with monoclonal similar bevacizumab ranibizumab.
Язык: Английский
Процитировано
2
Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12
Опубликована: Март 20, 2025
RNA therapeutics are emerging as a promising approach for cardiovascular diseases (CVDs) management, offering targeted gene regulation through modalities like mRNA, siRNA, and miRNA. In recent years, researchers have conducted lot of research on the application technology in treatment CVDs. Despite hurdles off-target effects immune responses, clinical trial outcomes encouraging. This review synthesizes current progress CVDs, examining their mechanisms, advantages, challenges delivery safety. We highlight potential personalized medicine, combination artificial intelligence (AI) bioinformatics advancing therapeutics. The future CVDs is poised significant impact, necessitating continued interdisciplinary collaboration to optimize these treatments ensure patient safety efficacy.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus of the coronaviridae family. The enters cell through binding to corresponding receptor angiotensin-converting enzyme (ACE2) on host membrane with spike protein (S protein) its envelope; thus, we can design inhibitors that bind S block entry into cells. Aptamers are single stranded DNA or RNA molecules form specific three-dimensional structures and their target high affinity specificity thus promising candidates for inhibitors. This paper reviews replication cycle mechanisms SARS-CoV-2 as well preparation principle characteristics aptamers, features discussion advantages using aptamers prevent from infecting cells, finally summarizes research progress in protein-blocking aptamers.
Язык: Английский
Процитировано
0
Biosensors, Год журнала: 2025, Номер 15(5), С. 277 - 277
Опубликована: Апрель 29, 2025
Aptamers have emerged as powerful molecular recognition elements for biosensing applications, offering high specificity, stability, and adaptability. This review explores key considerations in designing aptamer-based sensors (aptasensors), with a focus on biomarker selection, aptamer design, detection immobilization strategies. However, challenges such biofluid stability reversibility must be addressed to improve biosensor performance. In this study, the potential of platforms diagnostics is explored, emphasizing their advantages future applications. Looking ahead, advances multifunctional aptamers, integration nanomaterials, computational optimization are highlighted promising directions enhancing effectiveness biosensing.
Язык: Английский
Процитировано
0
Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 117361 - 117361
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
World Journal of Microbiology and Biotechnology, Год журнала: 2025, Номер 41(6)
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0