Integrative Analysis of EPHX4 as a Novel Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma DOI Open Access

P Liu,

Yutong Chen

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5095 - 5095

Опубликована: Май 26, 2025

Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality, necessitating the identification novel biomarkers for improved prognosis and diagnosis. This study investigates role epoxide hydrolase 4 (EPHX4), member family, in LUAD. Using data sourced from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases, which were subsequently validated by Gene Omnibus (GEO), we analyzed levels EPHX4 expression, mutation, methylation tumors versus normal tissues. Our findings revealed significant upregulation LUAD tissues compared to lung (p < 0.001), correlating with poorer overall survival (OS), disease-specific (DSS), progression-free interval (PFI). Furthermore, exhibited considerable diagnostic potential, as demonstrated an area under curve (AUC) 0.854 Receiver Operating Characteristic (ROC) analysis. Notably, expression was associated immune infiltration, specifically Th2 cells, neutrophils, macrophages, along checkpoint molecules including PD-L1, PD-L2, TIM-3. Additionally, involved pivotal tumor-associated pathways, particularly cell cycle regulation. In conclusion, elevated is indicative may play evasion dysregulation, highlighting its potential promising biomarker diagnosis prognostic prediction

Язык: Английский

Correlation Study of Perioperative Nutritional Support and Postoperative Complication Rates in Colon Cancer Patients DOI Creative Commons

Xuchen Chen,

Binbin Chen

Current Problems in Surgery, Год журнала: 2025, Номер unknown, С. 101753 - 101753

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

3

Integrative Analysis of EPHX4 as a Novel Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma DOI Open Access

P Liu,

Yutong Chen

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5095 - 5095

Опубликована: Май 26, 2025

Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality, necessitating the identification novel biomarkers for improved prognosis and diagnosis. This study investigates role epoxide hydrolase 4 (EPHX4), member family, in LUAD. Using data sourced from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases, which were subsequently validated by Gene Omnibus (GEO), we analyzed levels EPHX4 expression, mutation, methylation tumors versus normal tissues. Our findings revealed significant upregulation LUAD tissues compared to lung (p < 0.001), correlating with poorer overall survival (OS), disease-specific (DSS), progression-free interval (PFI). Furthermore, exhibited considerable diagnostic potential, as demonstrated an area under curve (AUC) 0.854 Receiver Operating Characteristic (ROC) analysis. Notably, expression was associated immune infiltration, specifically Th2 cells, neutrophils, macrophages, along checkpoint molecules including PD-L1, PD-L2, TIM-3. Additionally, involved pivotal tumor-associated pathways, particularly cell cycle regulation. In conclusion, elevated is indicative may play evasion dysregulation, highlighting its potential promising biomarker diagnosis prognostic prediction

Язык: Английский

Процитировано

0