Novel approaches of mycosynthesized zinc oxide nanoparticles (ZnONPs) using Pleurotus sajor-caju extract and their biological and environmental applications
Environmental Geochemistry and Health,
Год журнала:
2024,
Номер
46(10)
Опубликована: Сен. 23, 2024
Язык: Английский
Unveiling Phytochemicals and Antioxidant, Cytotoxic, Antithrombotic, Anti-Inflammatory, Analgesic, Hypoglycemic and Antidiarrheal Activities from the Leaves Extract of Zanthoxylum rhetsa (Roxb.) DC
Natural Product Communications,
Год журнала:
2025,
Номер
20(2)
Опубликована: Фев. 1, 2025
Objectives
This
study
aimed
to
investigate
the
chemico-pharmacological
properties
of
leaves
methanolic
extract
(ME)
Zanthoxylum
rhetsa
(Roxb.)
and
its
various
solvent
fractions,
focusing
on
antioxidant,
cytotoxic,
thrombolytic,
anti-inflammatory,
analgesic,
hypoglycaemic,
antidiarrheal
effects.
Methods
Phytochemicals
in
ME
were
identified
characterized
using
gas
chromatography
mass
spectrometry
(GC-MS).
Antioxidant
activity
was
measured
via
DPPH
(2,
2-diphenyl-1-picrylhydrazyl)
scavenging
assay
measuring
total
phenolic
content
(TPC).
Anti-inflammatory,
cytotoxic
effects
evaluated
membrane
stabilization,
clot
lysis,
brine
shrimp
bioassays,
respectively.
In
vivo
evaluations
antidiarrheal,
analgesic
activities
(200,
400
600
mg/kg
bw)
conducted
mice
model.
Results
A
65
phytoconstituents
ME,
where
13-docosenamide
(Z)
(17.78%)
phytol
(10.64%)
most
abundant.
The
aqueous
soluble
fraction
(AQSF)
exhibited
highest
TPC
(181.875
mg
GAE/gm
extractive)
antioxidant
efficacy
(IC
50
=
4.78
μg/mL).
AQSF
also
promising
antithrombotic
properties,
showing
over
88%
lysis
capacity.
Furthermore,
chloroform
(CSF)
displayed
93.2%
haemolysis
inhibition
under
heat-induced
conditions,
while
46.8%
hypotonic
conditions.
All
tested
three
doses
showed
dose-dependent
statistically
significant
(p
<
0.05)
efficacy,
only
200
bw
hypoglycaemic
acute
oral
toxicity
test,
median
lethal
dose
greater
than
4000
bw.
Conclusions
Z.
leaf
extractives
demonstrated
antithrombotic,
effects,
supporting
traditional
uses
plant
species.
Further
extensive
investigation,
particularly
fraction,
is
recommended
identify
responsible
lead
compounds.
Язык: Английский
Biological mosquiticidal agents: potential and effects on non-target organisms
Current Opinion in Environmental Science & Health,
Год журнала:
2024,
Номер
41, С. 100567 - 100567
Опубликована: Авг. 3, 2024
Язык: Английский
Fusarium begoniae metabolites: a promising larvicidal, pupicidal potential, histopathological alterations and detoxifications enzyme profiles of medically important mosquito vector Aedes aegypti, Culex quinquefasciatus and Anopheles stephensi
3 Biotech,
Год журнала:
2024,
Номер
14(10)
Опубликована: Сен. 10, 2024
Язык: Английский