Abstract
Erythrocytes
are
the
most
abundant
cells
in
blood.
As
results
of
long‐term
natural
selection,
their
specific
biconcave
discoid
morphology
and
cellular
composition
responsible
for
gaining
excellent
biological
performance.
Inspired
by
intrinsic
features
erythrocytes,
various
artificial
biomaterials
emerge
find
broad
prospects
biomedical
applications
such
as
therapeutic
delivery,
bioimaging,
tissue
engineering.
Here,
a
comprehensive
review
from
fabrication
to
erythrocyte‐inspired
functional
materials
is
given.
After
summarizing
mimicking
functions
synthesis
strategies
particles
with
morphologies
presented.
The
emphasis
on
practical
these
bioinspired
materials.
perspectives
future
possibilities
advanced
also
discussed.
It
hoped
that
summary
existing
studies
can
inspire
researchers
develop
novel
biomaterials;
thus,
accelerating
progress
toward
clinical
applications.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(3), С. 2054 - 2061
Опубликована: Янв. 9, 2024
Natural
proteins
are
highly
optimized
for
function
but
often
difficult
to
produce
at
a
scale
suitable
biotechnological
applications
due
poor
expression
in
heterologous
systems,
limited
solubility,
and
sensitivity
temperature.
Thus,
general
method
that
improves
the
physical
properties
of
native
while
maintaining
could
have
wide
utility
protein-based
technologies.
Here,
we
show
deep
neural
network
ProteinMPNN,
together
with
evolutionary
structural
information,
provides
route
increasing
protein
expression,
stability,
function.
For
both
myoglobin
tobacco
etch
virus
(TEV)
protease,
generated
designs
improved
elevated
melting
temperatures,
TEV
identified
multiple
catalytic
activity
as
compared
parent
sequence
previously
reported
variants.
Our
approach
should
be
broadly
useful
improving
biotechnologically
important
proteins.
Brain
iron
homeostasis
is
maintained
through
the
normal
function
of
blood-brain
barrier
and
regulation
at
systemic
cellular
levels,
which
fundamental
to
brain
function.
Excess
can
catalyze
generation
free
radicals
Fenton
reactions
due
its
dual
redox
state,
thus
causing
oxidative
stress.
Numerous
evidence
has
indicated
diseases,
especially
stroke
neurodegenerative
are
closely
related
mechanism
imbalance
in
brain.
For
one
thing,
diseases
promote
accumulation.
another,
accumulation
amplifies
damage
nervous
system
exacerbates
patients'
outcomes.
In
addition,
triggers
ferroptosis,
a
newly
discovered
iron-dependent
type
programmed
cell
death,
neurodegeneration
received
wide
attention
recent
years.
this
context,
we
outline
metabolism
focus
on
current
stroke,
Alzheimer's
disease,
Parkinson's
disease.
Meanwhile,
also
discuss
ferroptosis
simultaneously
enumerate
drugs
for
chelators
inhibitors.
Clinical Nutrition,
Год журнала:
2024,
Номер
43(3), С. 825 - 857
Опубликована: Янв. 30, 2024
BackgroundTrace
elements
and
vitamins,
named
together
micronutrients
(MNs),
are
essential
for
human
metabolism.
The
importance
of
MNs
in
common
pathologies
is
recognized
by
recent
research,
with
deficiencies
significantly
impacting
the
outcome.ObjectiveThis
short
version
guideline
aims
to
provide
practical
recommendations
clinical
practice.MethodsAn
extensive
search
literature
was
conducted
databases
Medline,
PubMed,
Cochrane,
Google
Scholar,
CINAHL
initial
guideline.
focused
on
physiological
data,
historical
evidence
(for
papers
published
before
PubMed
release
1996),
observational
and/or
randomized
trials.
For
each
MN,
main
functions,
optimal
analytical
methods,
impact
inflammation,
potential
toxicity,
provision
during
enteral
or
parenteral
nutrition
were
addressed.
SOP
wording
applied
strength
recommendations.ResultsThe
limited
number
interventional
trials
prevented
meta-analysis
led
a
low
level
most
recommendations.
underwent
consensus
process,
which
resulted
percentage
agreement
(%):
strong
required
>90
%
votes.
Altogether
proposes
3
general
specific
26
MNs.
Monitoring
management
strategies
proposed.ConclusionThis
MN
should
facilitate
handling
at-risk
diseases,
whilst
offering
advice
monitoring
nutritional
support.
Biology,
Год журнала:
2021,
Номер
10(9), С. 852 - 852
Опубликована: Авг. 31, 2021
COVID-19
has
specific
characteristics
that
distinguish
this
disease
from
many
other
infections.
We
suggest
the
pathogenesis
of
severe
forms
can
be
associated
with
acidosis.
This
review
article
discusses
several
mechanisms
potentially
linking
damaging
effects
acidosis
and
shows
existence
a
vicious
cycle
between
development
hypoxia
in
patients.
At
early
stages
disease,
inflammation,
difficulty
gas
exchange
lungs
thrombosis
collectively
contribute
to
onset
In
accordance
Verigo-Bohr
effect,
decrease
blood
pH
leads
oxygen
saturation,
which
contributes
exacerbation
results
deterioration
patient’s
condition.
A
also
cause
conformational
changes
S-protein
virus
thus
lead
affinity
avidity
protective
antibodies.
Hypoxia
dysregulation
immune
system
multidirectional
pro-
anti-inflammatory
reactions,
resulting
“cytokine
storm”.
review,
we
highlight
potential
importance
supporting
normal
as
an
approach
therapy.
Pharmacological Reviews,
Год журнала:
2022,
Номер
74(3), С. 825 - 875
Опубликована: Июнь 23, 2022
Carbon
monoxide
(CO)
has
been
firmly
established
as
an
endogenous
signaling
molecule
with
a
variety
of
pathophysiological
and
pharmacological
functions,
including
immunomodulation,
organ
protection,
circadian
clock
regulation,
among
many
others.
In
terms
its
molecular
mechanism(s)
action,
CO
is
known
to
bind
large
number
hemoproteins
at
least
25
identified
targets,
hemoglobin,
myoglobin,
neuroglobin,
cytochrome
c
oxidase,
P450,
soluble
guanylyl
cyclase,
myeloperoxidase,
some
ion
channels
dissociation
constant
values
spanning
the
range
sub-nM
high
μM.
Although
CO's
binding
affinity
targets
extensively
studied
established,
there
pressing
need
incorporate
such
information
into
analysis
biologic
response
in
context
dosage.
Especially
important
understand
reservoir
role
hemoglobin
storage,
transport,
distribution,
transfer.
We
critically
review
literature
inject
sense
quantitative
assessment
our
analyses
various
relationships
affinity,
concentration,
target
occupancy
level,
anticipated
actions.
hope
that
this
presents
picture
overall
landscape
engagement
stimulates
additional
research,
helps
move
field
direction
examining
individual
all
concentration
available
CO.
believe
work
will
help
further
understanding
relationship
functions
eventual
development
CO-based
therapeutics.
Significance
Statement
The
carbon
therapeutic
agent
significantly
rely
on
therapeutically
relevant
varying
affinity.
This
examines
by
quantitatively
analyzing
intricate
for
CO,
state
carboxyhemoglobin
provide
holistic
approach
action
Arteriosclerosis Thrombosis and Vascular Biology,
Год журнала:
2023,
Номер
43(8), С. 1349 - 1361
Опубликована: Июнь 15, 2023
Independent
of
etiology,
hemolytic
diseases
are
associated
with
thrombosis,
inflammation
and
immune
dysregulation,
all
together
contributing
to
organ
damage
poor
outcome.
Beyond
anemia
the
loss
anti-inflammatory
functions
red
blood
cells,
hemolysis
leads
release
damage-associated
molecular
patterns
including
ADP,
hemoglobin,
heme,
which
act
through
multiple
receptors
signaling
pathways
fostering
a
hyperinflammatory
hypercoagulable
state.
Extracellular
free
heme
is
promiscuous
alarmin
capable
triggering
oxido-inflammatory
thrombotic
events
by
inducing
activation
platelets,
endothelial
innate
cells
as
well
coagulation
complement
cascades.
In
this
review,
we
discuss
main
mechanisms
and,
in
particular,
drive
thrombo-inflammatory
milieu
consequences
on
host
response
secondary
infections.
International Journal of Biological Sciences,
Год журнала:
2020,
Номер
17(1), С. 62 - 72
Опубликована: Ноя. 6, 2020
Multi-system
involvement
and
rapid
clinical
deterioration
are
hallmarks
of
coronavirus
disease
2019
(COVID-19)
related
mortality.
The
unique
phenomena
in
severe
COVID-19
can
be
perplexing,
they
include
disproportionately
hypoxemia
relative
to
lung
alveolar-parenchymal
pathology
deterioration,
with
poor
response
O
