Modeling Kaempferol as a Potential Pharmacological Agent for COVID-19/PF Co-Occurrence Based on Bioinformatics and System Pharmacological Tools

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Июнь 8, 2022

Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects expected become a potential COVID-19 PF comorbidities. Therefore, this study explored the targets molecular mechanisms of kaempferol against co-occurrence by bioinformatics network pharmacology. Methods: Various open-source databases Venn Diagram tool were applied confirm Protein-protein interaction (PPI), MCODE, key transcription factors, tissue-specific enrichment, docking, Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses used clarify influential Results: 290 203 factors captured. Epidermal growth factor receptor (EGFR), proto-oncogene tyrosine-protein kinase SRC (SRC), mitogen-activated protein 3 (MAPK3), 1 (MAPK1), 8 (MAPK8), RAC-alpha serine/threonine-protein (AKT1), p65 (RELA) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) identified as most critical targets, showed effective binding activities above eight targets. Further, anti-COVID-19/PF associated regulation inflammation, oxidative stress, immunity, virus infection, cell process metabolism. EGFR, interleukin 17 (IL-17), tumor necrosis (TNF), hypoxia inducible (HIF-1), phosphoinositide 3-kinase/AKT serine/threonine (PI3K/AKT) Toll-like signaling pathways pathways. Conclusion: candidate The underlying may be related (EGFR, SRC, MAPK3, MAPK1, MAPK8, AKT1, RELA, PIK3CA so on) IL-17, TNF, HIF-1, PI3K/AKT This contributes guiding development new drugs

Язык: Английский

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“Long COVID-19” and viral “fibromyalgia-ness”: Suggesting a mechanistic role for fascial myofibroblasts (Nineveh, the shadow is in the fascia)

Frontiers in Medicine, Год журнала: 2023, Номер 10

Опубликована: Апрель 6, 2023

The coronavirus pandemic has led to a wave of chronic disease cases; “Long COVID-19” is recognized as new medical entity and resembles “fibromyalgia” which, likewise, lacks clear mechanism. Observational studies indicate that up 30%–40% convalescent COVID-19 patients develop widespread pain fatigue fulfill the 2016 diagnostic criteria for “fibromyalgia.” A recent study suggested theoretical neuro-biomechanical model (coined “Fascial Armoring”) help explain pathogenesis cellular pathway fibromyalgia, pointing toward mechanical abnormalities in connective tissue fascia, driven by contractile myo/fibroblasts altered extracellular matrix remodeling with downstream corresponding neurophysiological aberrations. This may several fibromyalgia’s manifestations such pain, distribution trigger points/tender spots, hyperalgesia, fatigue, cardiovascular abnormalities, metabolic autonomic small fiber neuropathy, various psychosomatic symptoms, lack obvious inflammation, silent imaging investigations. Pro-inflammatory pro-fibrotic pathways provide input into this mechanism via stimulation proto/myofibroblasts. In hypothesis theory paper Fascial Armoring presented “long immuno-rheumo-psycho-neurology. also used make testable experimental predictions on investigations predict risk relieving factors.

Язык: Английский

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COVID-19: A threat to the respiratory system

International Journal of Immunopathology and Pharmacology, Год журнала: 2024, Номер 38

Опубликована: Янв. 1, 2024

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes coronavirus disease-19 (COVID-19) that has emerged on a pandemic level. Coronaviruses are well-known to have negative impact the lungs and cardiovascular system. SARS-CoV-2 induces cytokine storm primarily targets lungs, causing widespread clinical disorders, including COVID-19. Although, positive individuals often show no or mild upper tract symptoms, cases can progress distress (ARDS). Novel CoV-2 infection in 2019 resulted viral pneumonia as well other complications extrapulmonary manifestation. ARDS is also linked higher risk of death. Now, it essential develop our perception long term sequelae for identification COVID-19 survivors who at developing chronic lung fibrosis. This review study was planned provide an overview effects various parts system such airways, pulmonary vascular, parenchymal neuromuscular potential mechanism related fibrosis patients with

Язык: Английский

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The Relationship Between Differential Expression of Non-coding RNAs (TP53TG1, LINC00342, MALAT1, DNM3OS, miR-126-3p, miR-200a-3p, miR-18a-5p) and Protein-Coding Genes (PTEN, FOXO3) and Risk of Idiopathic Pulmonary Fibrosis

Biochemical Genetics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

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Perfluorooctanoic acid induced lung toxicity via TGF-β1/Smad pathway, crosstalk between airway hyperresponsiveness and fibrosis: withdrawal impact

Environmental Science and Pollution Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Язык: Английский

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