International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113233 - 113233
Опубликована: Окт. 3, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 8, 2025
Язык: Английский
Процитировано
8
Hepatology Communications, Год журнала: 2024, Номер 8(5)
Опубликована: Май 1, 2024
Cholesterol is an essential lipid molecule in mammalian cells. It not only involved the formation of cell membranes but also serves as a raw material for synthesis bile acids, vitamin D, and steroid hormones. Additionally, it acts covalent modifier proteins plays crucial role numerous life processes. Generally, metabolic processes cholesterol absorption, synthesis, conversion, efflux are strictly regulated. Excessive accumulation body risk factor diseases such cardiovascular disease, type 2 diabetes, dysfunction–associated steatotic liver disease (MASLD). In this review, we first provide overview discovery fundamental process metabolism. We then summarize relationship between dietary intake developing MASLD, animal models MASLD specifically established with cholesterol-containing diet. end, cholesterol-induced inflammation initiation development discussed.
Язык: Английский
Процитировано
9
Bioorganic & Medicinal Chemistry, Год журнала: 2024, Номер 112, С. 117874 - 117874
Опубликована: Авг. 16, 2024
Язык: Английский
Процитировано
7
International Immunopharmacology, Год журнала: 2025, Номер 156, С. 114678 - 114678
Опубликована: Апрель 18, 2025
Язык: Английский
Процитировано
1
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Июль 3, 2024
Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome characterized by the excessive accumulation of fat within cells, which can progress to end-stage in severe cases, posing threat life. Pyroptosis distinct, pro-inflammatory form cell death, differing from traditional apoptosis. In recent years, there has been growing research interest association between pyroptosis and NAFLD, encompassing mechanisms functions progression as well potential therapeutic targets. Controlled activate immune eliciting host responses shield body harm. However, undue activation may worsen inflammatory responses, induce cellular or tissue damage, disrupt potentially impact function. This review elucidates involvement key molecular players, including NOD-like receptor thermal protein domain associated 3(NLRP3) inflammasome, gasdermin D (GSDMD), caspase family, pathogenesis NAFLD. It emphasizes promising prospects targeting approach for NAFLD offers valuable insights into future directions field treatment.
Язык: Английский
Процитировано
5
Journal of Personalized Medicine, Год журнала: 2024, Номер 14(8), С. 798 - 798
Опубликована: Июль 29, 2024
Chronic liver diseases (CLD) stem from various causes and lead to a gradual progression that ultimately may result in fibrosis eventually cirrhosis. This process is typically prolonged asymptomatic, characterized by the complex interplay among cell types, signaling pathways, extracellular matrix components, immune responses. With prevalence of CLD increasing, diagnoses are often delayed, which leads poor prognoses some cases, need for transplants. Consequently, there an urgent development novel, non-invasive methods diagnosis monitoring CLD. In this context, serum biomarkers-safer, repeatable, more acceptable alternatives tissue biopsies-are attracting significant research interest, although their clinical implementation not yet widespread. review summarizes latest advancements biomarkers detecting hepatic fibrogenesis advocates concerted efforts consolidate current knowledge, thereby providing patients with early, effective, accessible facilitate personalized therapeutic strategies.
Язык: Английский
Процитировано
5
Nature Reviews Cardiology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 18, 2024
Язык: Английский
Процитировано
4
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 148 - 148
Опубликована: Фев. 25, 2025
(1) Background: Hepatic lipid accumulation is the initial factor in metabolic-associated fatty liver disease (MAFLD) type 2 diabetics, leading to accelerated damage. The NOD-like receptor protein 3 (NLRP3) inflammasome plays a critical role this process. Dapansutrile (DAPA) novel NLRP3 inhibitor; however, its effect on ectopic remains unclear. This study aimed investigate therapeutic of DAPA hepatic diabetic mouse model and potential mechanisms. (2) Methods: effects deposition function under metabolic stress were evaluated vivo using db/db high-fat diet (HFD) + streptozotocin (STZ) models. Additionally, mechanism cellular deposition, mitochondrial oxidative stress, inflammation assessed HepG2 cells treated with free acids (FFA) DAPA. (3) Results: Our findings indicated that treatment improved glucose metabolism mice, particularly addressing heterotopic insulin resistance. also ameliorated mitochondrial-related functions through NLRP3-Caspase-1 signaling axis. (4) Conclusions: Targeting may represent approach for diabetes-related diseases.
Язык: Английский
Процитировано
0
Annals of Hepatology, Год журнала: 2025, Номер unknown, С. 101897 - 101897
Опубликована: Март 1, 2025
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays a critical role in the progression of metabolic dysfunction-associated steatohepatitis (MASH). Here, we investigated effects naringenin (NAR) on early hepatocellular carcinoma (HCC) experimentally induced rat MASH model and whether NLRP3 inflammasome/pyroptosis pathway was involved. The animals were fed hepatopathogenic diet for 16 weeks carbon tetrachloride (400 mg/kg, i.p.) diethylnitrosamine (40 injected once week. NAR administered at 100 mg/kg p.o. MASHHCC protocol evaluated using biochemical, histological, silico, molecular biological approaches. significantly mitigated liver damage, as evidenced by reduction damage markers. It also reduced steatosis inflammation, determined decreased lipid accumulation sterol regulatory element-binding protein 1C, interleukins 1-beta 18, nuclear factor kappa B levels, increased peroxisome proliferator-activated gamma levels. inhibits formation NLRP3, including recruitment caspase-1 gasdermin D proteins, reduces levels transforming growth factor-beta, alpha-smooth muscle actin, hepatic collagen 1, thereby diminishing extracellular matrix synthesis. Furthermore, gamma-glutamyl transpeptidase activity, glutathione S-transferase pi proliferation marker KI67 considerably reduced. Our findings show that has potential to inhibit HCC context MASH, suggesting could be used treatment humans.
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Март 28, 2025
The steatosis, activity, and fibrosis (SAF) score is a histological scoring system developed by the European Association for Study of Liver to evaluate liver biopsy samples in cases non-alcoholic fatty disease (NAFLD). Based on histopathological results SAF scores, NAFLD patients were categorized into mild, moderate, severe groups. We compared differences between these groups identified risk factors influencing lesion severity. gathered data from 539 who underwent percutaneous confirmation at Beijing Ditan Hospital January 2018 December 2022. All biopsies graded according system, severity was classified as or severe. gender, age, BMI, history diabetes, hypertension, aspartate aminotransferase (AST), alanine (ALT), serum cholesterol levels, other among with varying degrees Additionally, we explored that influenced lesions. A total enrolled this study, ages ranging 6 79 years. Among them, there 325 men 214 women an average age 39 ± 13 divided three based severity: mild group (162 cases), moderate (210 (167 cases). showed significant terms composition, high-calorie diet, family ALT, AST, GGT, bile acids, cholinesterase, glycosylated albumin, blood glucose, uric acid, type III procollagen, human laminin, stiffness, hepatic steatosis. steatosis play critical roles progression contribute high pathological scores patients.
Язык: Английский
Процитировано
0