Clinics, Год журнала: 2024, Номер 80, С. 100544 - 100544
Опубликована: Ноя. 26, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 10, 2025
Lactate, long viewed as a byproduct of glycolysis and metabolic waste. Initially identified within the context yogurt fermentation, lactate's role extends beyond culinary applications to its significance in biochemical processes. Contemporary research reveals that lactate functions not merely terminal product but also nexus for initiating physiological pathological responses body. Lysine lactylation (Kla), novel post-translational modification (PTM) proteins, has emerged pivotal mechanism by which exerts regulatory influence. This epigenetic potential alter gene expression patterns, thereby impacting Increasing evidence indicates correlation between adverse prognosis various malignancies. Consequently, this review article aims encapsulate proteins interact with lactate, elucidate tumorigenesis progression, explore therapeutic targets afforded modulation lactylation. The objective is clarify oncogenic provide strategic framework future directions burgeoning field.
Язык: Английский
Процитировано
3
Theranostics, Год журнала: 2025, Номер 15(5), С. 1787 - 1821
Опубликована: Янв. 2, 2025
Lactate is an indispensable substance in various cellular physiological functions and plays regulatory roles different aspects of energy metabolism signal transduction. Lactylation (Kla), a key pathway through which lactate exerts its functions, has been identified as novel posttranslational modification (PTM). Research indicates that Kla essential balancing mechanism variety organisms involved many biological processes pathways. closely related to disease development represents potential important new drug target. In line with existing reports, we searched for newly discovered sites on histone nonhistone proteins; reviewed the mechanisms (particularly focusing enzymes directly reversible regulation Kla, including "writers" (modifying enzymes), "readers" (modification-binding "erasers" (demodifying enzymes); summarized crosstalk between PTMs help researchers better understand widespread distribution diverse functions. Furthermore, considering "double-edged sword" role both pathological contexts, this review highlights "beneficial" states (energy metabolism, inflammatory responses, cell fate determination, development, etc.) "detrimental" pathogenic or inducive effects processes, particularly malignant tumors complex nontumor diseases. We also clarify molecular health disease, discuss feasibility therapeutic Finally, describe detection technologies their applications diagnosis clinical settings, aiming provide insights treatment diseases accelerate translation from laboratory research practice.
Язык: Английский
Процитировано
2
Engineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102670 - 102670
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Clinical Science, Год журнала: 2025, Номер 139(02), С. 151 - 169
Опубликована: Янв. 1, 2025
Lactylation, a post-translational modification, has been linked to gene transcription regulation through epigenetic modulation in various pathophysiological processes. The lactylation regulatory proteins, known as writers, erasers, and readers, govern their dynamics by adding, removing, recognizing lactyl groups on proteins. Macrophages, cells of the immune system, maintain homeostasis, responding dynamically diverse internal external stimuli. Emerging researches unveil that lactylation, inducing macrophage activation polarization, affects functionality pathological conditions such inflammation, tumor microenvironment, fibrosis. Evidence progressively indicates lactate-driven alterations levels within macrophages can influence pathogenesis numerous diseases. This review aims systematically summarize research progress macrophages, explore its functions mechanisms which contributes pathology different disease phenotypes, propose future directions along with potential diagnostic therapeutic strategies.
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117934 - 117934
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
1
Experimental Hematology and Oncology, Год журнала: 2025, Номер 14(1)
Опубликована: Март 8, 2025
Cancer remains the leading cause of mortality worldwide, and emergence drug resistance has made identification new therapeutic targets imperative. Lactate, traditionally viewed as a byproduct glycolysis with limited ATP-producing capacity, recently gained recognition critical signaling molecule. It plays key role not only in cancer cell metabolism but also shaping tumor microenvironment (TME). Histone lysine lactylation, newly identified post-translational modification, been shown to influence range cellular processes cancer. Current research focuses on mechanisms functions histone lactylation cancer, including its gene expression regulation, signal transduction, protein synthesis. However, despite these advancements, there are still plenty barriers quest unravel modification. The single-cell spatial transcriptomics may offer valuable insights for selecting targets. This review provides comprehensive summary applications modification clinical settings. Through detailed analysis, we identify challenges limitations that exist current landscape. These lay groundwork future studies by highlighting promising directions.
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2024, Номер 14(10), С. 1202 - 1202
Опубликована: Сен. 24, 2024
Lactate accumulation and macrophage infiltration are pivotal features of both chronic inflammation cancer. Lactate, once regarded merely as an aftereffect glucose metabolism, is now gaining recognition for its burgeoning spectrum biological roles immunomodulatory significance. Recent studies have evidenced that macrophages display divergent immunophenotypes in different diseases, which play a role disease management by modulating polarization within the microenvironment. The specific patterns high-lactate environment their contribution to progression cancer remain contentious. This review presents current evidence on crosstalk lactate Additionally, we provide in-depth exploration yet enigmatic mechanisms through orchestrates pathogenesis, thereby offering novel perspectives development targeted therapeutic interventions
Язык: Английский
Процитировано
3
Gene, Год журнала: 2025, Номер 940, С. 149220 - 149220
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
0
Translational Cancer Research, Год журнала: 2025, Номер 14(1), С. 296 - 312
Опубликована: Янв. 1, 2025
The occurrence rate of liver cancer is increasing in recent years. significance lactylation tumor cells should not be neglected. This study aimed to discover a gene signature related that can used for diagnostic applications. Data were downloaded from Cancer Genome Atlas (TCGA), GSE14520, GSE84402, and GSE62232 datasets. Differential analysis random forest performed hepatocellular carcinoma (HCC). Receiver operating characteristic (ROC) curve was evaluate efficiency, logistic regression established obtain the risk score equation. Besides, expression genes identified by TCGA database verified real-time quantitative polymerase chain reaction (RT-PCR). In order analyze prognostic performance, patients diagnosed with HCC stratified into either high or low categories based on median score. addition, immunotherapy drug sensitivity groups assessed. performance model validated Gene Expression Omnibus (GEO) dataset. had worse outcomes than those database. ROC curves showed characteristics lactylation-related good predictive capability. Furthermore, we developed nomogram patients, utilizing data resources TCGA. Finally, terms assessing potency group lower Tumor Immune Dysfunction Exclusion (TIDE) score, indicating response immunotherapy. Our identification associated presents promising avenue development targeted immunotherapeutic strategies.
Язык: Английский
Процитировано
0