Cancer
is
a
significant
global
health
concern,
responsible
for
16.8%
of
deaths
and
22.8%
noncommunicable
diseases.
Currently,
cancer
ranks
as
the
second
leading
cause
mortality,
with
projections
indicating
its
rise
to
top
by
2060.
The
genomic,
transcriptomic,
proteomic
diversity
cells
contributes
their
increased
resistance
treatment,
enhanced
survival,
propensity
metastasis.
Conventional
treatments
like
surgery,
chemotherapy,
radiation
often
result
in
damage
healthy
tissues.
Phytochemicals,
naturally
occurring
plant
compounds,
have
gained
attention
promising
therapies
due
anticancer,
antioxidant,
anti-inflammatory
properties.
This
chapter
delves
into
recent
advances
phytochemical
research,
emphasizing
molecular
mechanisms
innovative
approaches
incorporating
these
compounds
treatment.
Additionally,
it
explores
challenges
opportunities
leveraging
phytochemicals
bridge
traditional
medicine
modern
oncology,
offering
hope
treatment
outcomes
improved
patient
quality
life.
Natural Product Communications,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
Paramignya
trimera
(
P.
(Oliv.)
Guillaum),
a
Vietnamese
plant
has
showed
potential
anticancer
activities.
Extracts
from
the
plant's
roots,
stems,
and
leaves
have
shown
cytotoxicity
against
variety
of
cancer
cell
lines.
The
mechanisms
behind
these
actions
include
triggering
apoptosis,
blocking
invasion,
targeting
particular
signaling
pathways.
This
review
collected
data
available
literature
on
trimera's
properties
compiled
database
its
isolated
compounds.
Results
indicate
that
extracts
specific
compounds,
such
as
coumarins
acridones,
possess
potential.
Particularly,
acridones
exhibited
comparable
or
superior
HepG2
MCF-7
cells
(IC
50
values
0.43-1.19
μM
0.22-0.40
μM,
respectively)
compared
to
doxorubicin
0.28
1.31
μM).
Coumarins
like
8-geranylumbelliferone
ostruthin
target
IKKβ,
while
paratrimerin
W
shows
various
cancers.
Paratrimerin
I
exhibit
due
N-methyl,
C-4
methoxy,
C-5
hydroxy
groups
in
acridone
skeleton.
However,
further
research
is
needed
elucidate
precise
action
evaluate
safety
efficacy
trimera-derived
compounds
clinical
settings.
identification
146
provides
valuable
resource
for
future
drug
discovery
efforts.
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Апрель 17, 2025
Abstract
Although
cancer
chemopreventive
agents
have
been
confirmed
to
effectively
protect
high-risk
populations
from
invasion
or
recurrence,
only
over
ten
drugs
approved
by
the
U.S.
Food
and
Drug
Administration.
Therefore,
screening
potent
is
crucial
reduce
constantly
increasing
incidence
mortality
rate
of
cancer.
Considering
lengthy
prevention
process,
an
ideal
agent
should
be
nontoxic,
inexpensive,
oral.
Natural
compounds
become
a
natural
treasure
reservoir
for
chemoprevention
because
their
superior
ease
availability,
cost-effectiveness,
safety.
The
benefits
as
in
various
studies.
In
light
this,
present
review
intended
fully
delineate
entire
scope
chemoprevention,
primarily
focuses
on
aspects
based
compounds,
specifically
focusing
mechanism
action
prevention,
discussing
detail
how
they
exert
effects
affecting
classical
signaling
pathways,
immune
checkpoints,
gut
microbiome.
We
also
introduce
novel
strategies
summarize
role
improving
chemotherapy
regimens.
Furthermore,
we
describe
discovering
anticancer
with
low
abundance
high
activity,
revealing
broad
prospects
drug
discovery
chemoprevention.
Moreover,
associate
precision
medicine,
discuss
challenges
encountered
Finally,
emphasize
transformative
potential
advancing
field
ability
more
effective
less
toxic
preventive
options
oncology.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 19, 2024
Abstract
The
evidence
linking
high
levels
of
environmental
pollutants
to
chronic
degenerative
diseases
is
alarming,
with
heavy
metals
(HM)
identified
as
a
key
factor.
Research
suggests
that
certain
phytochemicals
in
the
diet
can
reduce
HM
and
mitigate
their
adverse
health
effects.Curcumin
(Cur),
natural
polyphenol,
particularly
effective
protecting
against
Cadmium
(Cd)
toxicity.
present
study
demonstrates
preincubation
low
doses
Cur
(1
μM)
differentiated
HL-60
K-562
human
myeloid
cells
significantly
protect
cytotoxicity
induced
by
Cd
or
H
2
O
.
reduced
increased
reactive
oxygen
species
(ROS)
generated
inducing
protective
form
autophagy.
activated
mild
oxidative
stress
triggers
expression
Nrf2-dependent
transcripts,
such
HO
NQO1.
potential
chemopreventive
effects
redox
have
been
strengthened
observation
free
unmetabolized
detectable
inside
after
5
minutes
treatment,
its
presence
parallels
intracellular
GSH.
These
findings
suggest
supplementation
nutraceuticals
may
represent
promising
way
people
living
highly
polluted
areas
contaminants.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1340 - 1340
Опубликована: Окт. 8, 2024
Brazilian
red
propolis
has
attracted
attention
for
its
pharmacological
properties.
However,
signs
of
toxicity
were
recently
observed
in
long-term
studies
using
the
hydroalcoholic
extract
(RPHE),
likely
due
to
polyprenylated
benzophenones.
This
study
aimed
develop
a
benzophenone-free
(BFRP)
and
validate
an
HPLC-PDA
method
quantify
main
constituents:
isoliquiritigenin,
vestitol,
neovestitol,
medicarpine,
7-
