The emerging role of 12/15-lipoxygenase in ischemic stroke
Xuening Wang,
Qiuji Shao,
Yuan Gao
и другие.
Brain Research Bulletin,
Год журнала:
2025,
Номер
unknown, С. 111194 - 111194
Опубликована: Янв. 1, 2025
The
arachidonic
acid
metabolic
pathway
is
a
classic
inflammatory
pathway.
12/15-lipoxygenase
(LOX),
member
of
the
lipoxygenase
family
that
metabolizes
acid,
has
been
implicated
in
pathogenesis
numerous
central
nervous
system
(CNS)
diseases.
Ischemic
stroke
devastating
disease
which
occlusion
cerebral
arteries
leads
to
series
pathophysiological
changes
brain
tissue,
triggering
an
cascade
within
results
neuroinflammation.
Prior
research
shown
12/15-LOX
levels
are
elevated
following
stroke.
In
this
review,
we
elaborate
on
key
pathological
mechanisms
unfold
ischemic
stroke,
including
neuroinflammation,
oxidative
stress,
neuronal
apoptosis,
and
blood-brain
barrier
disruption,
present
evidence
demonstrating
inhibition
could
be
used
treat
through
various
avenues.
Furthermore,
list
currently
available
inhibitors
preclinical
or
clinical
applications,
offering
novel
insights
for
early
diagnosis,
prognosis
evaluation,
targeted
therapy
neurological
Язык: Английский
Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions
Antioxidants and Redox Signaling,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Significance:
Damage
after
stroke
is
not
only
limited
to
the
brain
but
also
often
occurs
in
remote
organs,
including
heart,
lung,
liver,
kidney,
digestive
tract,
and
spleen,
which
are
frequently
affected
by
complex
pathophysiological
changes.
The
organs
human
body
closely
connected,
signals
transmitted
through
various
molecular
substances
could
regulate
changes
of
organs.
Recent
Advances:
latest
studies
have
shown
that
inflammatory
response
plays
an
important
role
organ
damage
stroke,
can
aggravate
activating
oxidative
stress,
sympathetic
axis,
hypothalamic
disturbing
immunological
homeostasis.
Remote
cause
brain,
aggravating
damage.
Critical
Issues:
Therefore,
in-depth
exploration
mechanisms
adopting
corresponding
comprehensive
intervention
strategies
become
necessary
reduce
promote
protection.
Future
Directions:
strategy
involves
multifaceted
treatment
methods
such
as
inflammation
regulation,
antioxidants,
neural
stem
cell
differentiation.
It
provides
a
promising
alternative
for
recovery
patients
inspiration
future
research
treatment.
interconnected
at
level.
Only
levels
we
save
protect
greatest
extent.
Antioxid.
Redox
Signal.
00,
000-000.
Язык: Английский
In Vivo Neuroprotective Effects of Alpinetin Against Experimental Ischemic Stroke Damage Through Antioxidant and Anti-Inflammatory Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(11), С. 5093 - 5093
Опубликована: Май 26, 2025
Ischemic
stroke
is
the
most
common
type
of
and
poses
a
major
global
health
challenge
due
to
its
high
mortality
lasting
disability
impact.
The
onset
progression
ischemic
are
largely
linked
oxidative
stress
inflammatory
responses.
Alpinetin,
natural
flavonoid
found
in
ginger
family,
exhibits
various
pharmacological
properties,
including
antioxidant
anti-inflammatory
activities.
In
this
study,
neuroprotective
potential
alpinetin
attenuating
inflammation
against
cerebral
was
evaluated.
Ninety
male
Wistar
rats
were
randomly
assigned
sham
operation
group,
Rt.MCAO
Rt.MCAO+piracetam
Rt.MCAO+alpinetin
groups
(25,
50,
100
mg/kg
BW).
Cerebral
infarction
size,
neuronal
density,
activities
measured.
Three
days
treatment
with
markedly
reduced
infarct
volume
by
30%
compared
Rt.MCAO+vehicle-treated
group.
Additionally,
treated
exhibited
significant
increase
density
cortex,
as
well
CA1
CA3
regions
hippocampus.
Furthermore,
ameliorated
both
Rt.MCAO-induced
malondialdehyde
(MDA)
activity
decrease
catalase
(CAT),
glutathione
peroxidase
(GSH-Px),
superoxide
dismutase
(SOD)
cortex
Moreover,
COX-2
IL-6
protein
levels
assessed
using
western
blotting.
results
showed
that
(100
BW)
significantly
expression
Our
findings
suggest
mitigates
effects
ischemia-induced
brain
damage
through
properties
could
potentially
be
developed
therapeutic
agent
for
treatment.
Язык: Английский
Activation of Inflammasomes and Relevant Modulators for the Treatment of Microglia-mediated Neuroinflammation in Ischemic Stroke
Ze-Jie Zeng,
Xiaobing Lin,
Yang Liu
и другие.
Molecular Neurobiology,
Год журнала:
2024,
Номер
61(12), С. 10792 - 10804
Опубликована: Май 24, 2024
Язык: Английский
ROS-responsive Chitosan Bilirubin Nanoparticles loaded with Statin for Treatment of Cerebral Ischemia
Biomaterials Research,
Год журнала:
2024,
Номер
28
Опубликована: Янв. 1, 2024
Cerebral
ischemia
impairs
blood
circulation,
leading
to
elevated
reactive
oxygen
species
(ROS)
production.
A
ROS-responsive
delivery
of
drugs
can
enhance
the
therapeutic
efficacy
and
minimize
side
effects.
There
is
insufficient
evidence
on
impact
nanoparticles
ischemic
stroke.
We
developed
chitosan–bilirubin
(ChiBil)
target
acute
lesions
investigated
effect
atorvastatin-loaded
ChiBil.
randomly
assigned
rats
with
transient
middle
cerebral
artery
occlusion
(MCAO)
4
groups:
saline,
Statin,
ChiBil,
ChiBil-Statin.
These
groups
were
treated
daily
via
tail
vein
for
7
d.
Behavioral
assessment,
magnetic
resonance
(MR)
imaging,
evaluation
neuroinflammation,
blood–brain
barrier
(BBB)
integrity,
apoptosis,
neurogenesis
after
stroke
conducted.
In
vitro,
results
showed
nanoparticle
uptake
reduced
intracellular
ROS,
lipid
peroxidation,
inflammatory
cytokines
(IL-6
TNF-α).
vivo,
improved
motor
deficits
decreased
infarct
volumes
MR
images
in
ChiBil-Statin
group
compared
Control
day
(
P
<
0.05).
Furthermore,
expression
such
as
IL-1β
IL-6
was
Improvements
BBB
observed
group.
The
findings
demonstrated
that
intravenous
multifunctional
could
effectively
deliver
brain,
exerting
marked
synergistic
pleiotropic
neuroprotective
Therefore,
holds
promise
a
targeted
therapy
vascular
diseases
characterized
by
increased
ROS
production,
new
avenues
future
research
potential
clinical
applications.
Язык: Английский
Verbascum gimgimense an Endemic Turkish Plant: Evaluation of In Vitro Anticancer, Antioxidant, Enzyme Inhibitory Activities, and Phytochemical Profile
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(8)
Опубликована: Дек. 1, 2024
ABSTRACT
The
Verbascum
genus
has
gained
significant
attention
in
the
pharmaceutical
field,
particularly
recent
years,
due
to
its
valuable
medicinal
properties,
which
are
well‐recognized
complementary
and
alternative
medicine.
Certain
species
within
this
contain
essential
compounds
exhibit
a
wide
range
of
therapeutic
activities.
In
study,
ethanolic
extract
gimgimense
(VG)
was
analyzed
for
cytotoxic,
apoptotic,
antioxidant,
enzyme
inhibitory
as
well
phenolic
lipophilic
compounds.
were
identified
using
Exactive
Plus
Orbitrap
HPLC‐HRMS,
while
components
characterized
by
GC‐MS
analysis.
Neutral
Red
Uptake
(NRU)
cell
viability
assay
colony
formation
performed
assess
antiproliferative
anti‐colony
survival
effects
VG
on
A549
human
lung
adenocarcinoma
line.
Additionally,
wound
healing
measured
migration,
apoptotic
process
evaluated
Caspase‐3
ELISA
acridine
orange/ethidium
bromide
staining.
Protein
expression
levels
determined
western
blot
DPPH,
ABTS
FRAP,
CUPRAC
assays
used
determine
free
radical
scavenging,
reducing
power,
metal
chelating
activities,
respectively.
rich
dominant
components,
including
benzoic
acid
(6.809
mg/g
extract),
phloretic
(1.279
luteolin
7‐rutinoside
(2.799
luteoloside
(3.300
kuromanine
(3.456
rutin
hydrate
(2.015
extract).
Major
fatty
acids
included
palmitic
(17.3%),
stearic
(2.99%),
linoleic
(9.44%),
α‐linolenic
(26.48%).
treatment
significantly
reduced
ability,
decreased
closure,
increased
both
count
caspase‐3
activity
compared
control
group.
c‐PARP,
p53,
p21
substantially
elevated
controls.
addition
strong
power
activity,
exhibited
α‐amylase,
α‐glucosidase,
AChE,
BChE,
tyrosinase.
Our
study
demonstrates
that
possesses
antiproliferative,
enzyme‐inhibitory
properties.
V.
emerges
promising
natural
antioxidant
source
with
potentially
regulatory
key
enzymes
proteins,
could
contribute
managing
various
diseases
inspire
development
novel
strategies.
Язык: Английский
A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury
Archives of Gerontology and Geriatrics,
Год журнала:
2024,
Номер
131, С. 105739 - 105739
Опубликована: Дек. 31, 2024
Язык: Английский
An introduction to the special issue “Sam Enna legacy of Excellence”
Biochemical Pharmacology,
Год журнала:
2024,
Номер
228, С. 116510 - 116510
Опубликована: Авг. 30, 2024
Язык: Английский
Treatment of Acute and Long-COVID, Diabetes, Myocardial Infarction, and Alzheimer’s Disease: The Potential Role of a Novel Nano-Compound—The Transdermal Glutathione–Cyclodextrin Complex
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1106 - 1106
Опубликована: Сен. 12, 2024
Oxidative
stress
(OS)
occurs
from
excessive
reactive
oxygen
species
or
a
deficiency
of
antioxidants—primarily
endogenous
glutathione
(GSH).
There
are
many
illnesses,
acute
and
post-COVID-19,
diabetes,
myocardial
infarction
to
Alzheimer’s
disease,
that
associated
with
OS.
These
dissimilar
illnesses
are,
in
order,
viral
infections,
metabolic
disorders,
ischemic
events,
neurodegenerative
disorders.
Evidence
is
presented
(1)
OS
an
early
initiator
significant
promotor
their
progressive
pathophysiologic
processes,
(2)
reduction
may
prevent
later
serious
irreversible
complications,
(3)
GSH
OS,
(4)
can
likely
reduce
restore
adaptive
physiology,
(5)
effective
administration
be
accomplished
novel
nano-product,
the
GSH/cyclodextrin
(GC)
complex.
overlooked
pathological
process
illnesses.
Significantly,
complex,
therapeutic
now
available
Finally,
rigorous
prospective
studies
needed
confirm
efficacy
this
approach.
Язык: Английский