Treatment of Acute and Long-COVID, Diabetes, Myocardial Infarction, and Alzheimer’s Disease: The Potential Role of a Novel Nano-Compound—The Transdermal Glutathione–Cyclodextrin Complex DOI Creative Commons
Ray Yutani, Vishwanath Venketaraman, Nisar Sheren

и другие.

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1106 - 1106

Опубликована: Сен. 12, 2024

Oxidative stress (OS) occurs from excessive reactive oxygen species or a deficiency of antioxidants—primarily endogenous glutathione (GSH). There are many illnesses, acute and post-COVID-19, diabetes, myocardial infarction to Alzheimer’s disease, that associated with OS. These dissimilar illnesses are, in order, viral infections, metabolic disorders, ischemic events, neurodegenerative disorders. Evidence is presented (1) OS an early initiator significant promotor their progressive pathophysiologic processes, (2) reduction may prevent later serious irreversible complications, (3) GSH OS, (4) can likely reduce restore adaptive physiology, (5) effective administration be accomplished novel nano-product, the GSH/cyclodextrin (GC) complex. overlooked pathological process illnesses. Significantly, complex, therapeutic now available Finally, rigorous prospective studies needed confirm efficacy this approach.

Язык: Английский

The emerging role of 12/15-lipoxygenase in ischemic stroke DOI Creative Commons

Xuening Wang,

Qiuji Shao,

Yuan Gao

и другие.

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111194 - 111194

Опубликована: Янв. 1, 2025

The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), member of the lipoxygenase family that metabolizes acid, has been implicated in pathogenesis numerous central nervous system (CNS) diseases. Ischemic stroke devastating disease which occlusion cerebral arteries leads to series pathophysiological changes brain tissue, triggering an cascade within results neuroinflammation. Prior research shown 12/15-LOX levels are elevated following stroke. In this review, we elaborate on key pathological mechanisms unfold ischemic stroke, including neuroinflammation, oxidative stress, neuronal apoptosis, and blood-brain barrier disruption, present evidence demonstrating inhibition could be used treat through various avenues. Furthermore, list currently available inhibitors preclinical or clinical applications, offering novel insights for early diagnosis, prognosis evaluation, targeted therapy neurological

Язык: Английский

Процитировано

0

Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions DOI
Jie Wang, Sen Gao, Yue Cui

и другие.

Antioxidants and Redox Signaling, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Significance: Damage after stroke is not only limited to the brain but also often occurs in remote organs, including heart, lung, liver, kidney, digestive tract, and spleen, which are frequently affected by complex pathophysiological changes. The organs human body closely connected, signals transmitted through various molecular substances could regulate changes of organs. Recent Advances: latest studies have shown that inflammatory response plays an important role organ damage stroke, can aggravate activating oxidative stress, sympathetic axis, hypothalamic disturbing immunological homeostasis. Remote cause brain, aggravating damage. Critical Issues: Therefore, in-depth exploration mechanisms adopting corresponding comprehensive intervention strategies become necessary reduce promote protection. Future Directions: strategy involves multifaceted treatment methods such as inflammation regulation, antioxidants, neural stem cell differentiation. It provides a promising alternative for recovery patients inspiration future research treatment. interconnected at level. Only levels we save protect greatest extent. Antioxid. Redox Signal. 00, 000-000.

Язык: Английский

Процитировано

0

In Vivo Neuroprotective Effects of Alpinetin Against Experimental Ischemic Stroke Damage Through Antioxidant and Anti-Inflammatory Mechanisms DOI Open Access
Ratchaniporn Kongsui, Sitthisak Thongrong, Jinatta Jittiwat

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5093 - 5093

Опубликована: Май 26, 2025

Ischemic stroke is the most common type of and poses a major global health challenge due to its high mortality lasting disability impact. The onset progression ischemic are largely linked oxidative stress inflammatory responses. Alpinetin, natural flavonoid found in ginger family, exhibits various pharmacological properties, including antioxidant anti-inflammatory activities. In this study, neuroprotective potential alpinetin attenuating inflammation against cerebral was evaluated. Ninety male Wistar rats were randomly assigned sham operation group, Rt.MCAO Rt.MCAO+piracetam Rt.MCAO+alpinetin groups (25, 50, 100 mg/kg BW). Cerebral infarction size, neuronal density, activities measured. Three days treatment with markedly reduced infarct volume by 30% compared Rt.MCAO+vehicle-treated group. Additionally, treated exhibited significant increase density cortex, as well CA1 CA3 regions hippocampus. Furthermore, ameliorated both Rt.MCAO-induced malondialdehyde (MDA) activity decrease catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) cortex Moreover, COX-2 IL-6 protein levels assessed using western blotting. results showed that (100 BW) significantly expression Our findings suggest mitigates effects ischemia-induced brain damage through properties could potentially be developed therapeutic agent for treatment.

Язык: Английский

Процитировано

0

Activation of Inflammasomes and Relevant Modulators for the Treatment of Microglia-mediated Neuroinflammation in Ischemic Stroke DOI

Ze-Jie Zeng,

Xiaobing Lin,

Yang Liu

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10792 - 10804

Опубликована: Май 24, 2024

Язык: Английский

Процитировано

2

ROS-responsive Chitosan Bilirubin Nanoparticles loaded with Statin for Treatment of Cerebral Ischemia DOI Creative Commons
Raveena Nagareddy, Jahae Kim, Jihye Kim

и другие.

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Cerebral ischemia impairs blood circulation, leading to elevated reactive oxygen species (ROS) production. A ROS-responsive delivery of drugs can enhance the therapeutic efficacy and minimize side effects. There is insufficient evidence on impact nanoparticles ischemic stroke. We developed chitosan–bilirubin (ChiBil) target acute lesions investigated effect atorvastatin-loaded ChiBil. randomly assigned rats with transient middle cerebral artery occlusion (MCAO) 4 groups: saline, Statin, ChiBil, ChiBil-Statin. These groups were treated daily via tail vein for 7 d. Behavioral assessment, magnetic resonance (MR) imaging, evaluation neuroinflammation, blood–brain barrier (BBB) integrity, apoptosis, neurogenesis after stroke conducted. In vitro, results showed nanoparticle uptake reduced intracellular ROS, lipid peroxidation, inflammatory cytokines (IL-6 TNF-α). vivo, improved motor deficits decreased infarct volumes MR images in ChiBil-Statin group compared Control day ( P < 0.05). Furthermore, expression such as IL-1β IL-6 was Improvements BBB observed group. The findings demonstrated that intravenous multifunctional could effectively deliver brain, exerting marked synergistic pleiotropic neuroprotective Therefore, holds promise a targeted therapy vascular diseases characterized by increased ROS production, new avenues future research potential clinical applications.

Язык: Английский

Процитировано

1

Verbascum gimgimense an Endemic Turkish Plant: Evaluation of In Vitro Anticancer, Antioxidant, Enzyme Inhibitory Activities, and Phytochemical Profile DOI
Mehmet Kadir Erdoğan, Aydın SEVER, Ramazan Gündoğdu

и другие.

Cell Biochemistry and Function, Год журнала: 2024, Номер 42(8)

Опубликована: Дек. 1, 2024

ABSTRACT The Verbascum genus has gained significant attention in the pharmaceutical field, particularly recent years, due to its valuable medicinal properties, which are well‐recognized complementary and alternative medicine. Certain species within this contain essential compounds exhibit a wide range of therapeutic activities. In study, ethanolic extract gimgimense (VG) was analyzed for cytotoxic, apoptotic, antioxidant, enzyme inhibitory as well phenolic lipophilic compounds. were identified using Exactive Plus Orbitrap HPLC‐HRMS, while components characterized by GC‐MS analysis. Neutral Red Uptake (NRU) cell viability assay colony formation performed assess antiproliferative anti‐colony survival effects VG on A549 human lung adenocarcinoma line. Additionally, wound healing measured migration, apoptotic process evaluated Caspase‐3 ELISA acridine orange/ethidium bromide staining. Protein expression levels determined western blot DPPH, ABTS FRAP, CUPRAC assays used determine free radical scavenging, reducing power, metal chelating activities, respectively. rich dominant components, including benzoic acid (6.809 mg/g extract), phloretic (1.279 luteolin 7‐rutinoside (2.799 luteoloside (3.300 kuromanine (3.456 rutin hydrate (2.015 extract). Major fatty acids included palmitic (17.3%), stearic (2.99%), linoleic (9.44%), α‐linolenic (26.48%). treatment significantly reduced ability, decreased closure, increased both count caspase‐3 activity compared control group. c‐PARP, p53, p21 substantially elevated controls. addition strong power activity, exhibited α‐amylase, α‐glucosidase, AChE, BChE, tyrosinase. Our study demonstrates that possesses antiproliferative, enzyme‐inhibitory properties. V. emerges promising natural antioxidant source with potentially regulatory key enzymes proteins, could contribute managing various diseases inspire development novel strategies.

Язык: Английский

Процитировано

1

A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury DOI

Ling Lu,

Guoyang Zhou,

Xun Zhang

и другие.

Archives of Gerontology and Geriatrics, Год журнала: 2024, Номер 131, С. 105739 - 105739

Опубликована: Дек. 31, 2024

Язык: Английский

Процитировано

1

An introduction to the special issue “Sam Enna legacy of Excellence” DOI
Jacques Piette,

Lynn LeCount

Biochemical Pharmacology, Год журнала: 2024, Номер 228, С. 116510 - 116510

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

0

Treatment of Acute and Long-COVID, Diabetes, Myocardial Infarction, and Alzheimer’s Disease: The Potential Role of a Novel Nano-Compound—The Transdermal Glutathione–Cyclodextrin Complex DOI Creative Commons
Ray Yutani, Vishwanath Venketaraman, Nisar Sheren

и другие.

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1106 - 1106

Опубликована: Сен. 12, 2024

Oxidative stress (OS) occurs from excessive reactive oxygen species or a deficiency of antioxidants—primarily endogenous glutathione (GSH). There are many illnesses, acute and post-COVID-19, diabetes, myocardial infarction to Alzheimer’s disease, that associated with OS. These dissimilar illnesses are, in order, viral infections, metabolic disorders, ischemic events, neurodegenerative disorders. Evidence is presented (1) OS an early initiator significant promotor their progressive pathophysiologic processes, (2) reduction may prevent later serious irreversible complications, (3) GSH OS, (4) can likely reduce restore adaptive physiology, (5) effective administration be accomplished novel nano-product, the GSH/cyclodextrin (GC) complex. overlooked pathological process illnesses. Significantly, complex, therapeutic now available Finally, rigorous prospective studies needed confirm efficacy this approach.

Язык: Английский

Процитировано

0