Targeting ACSLs to modulate ferroptosis and cancer immunity
Trends in Endocrinology and Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
SLC35C2 promotes stemness and progression in hepatocellular carcinoma by activating lipogenesis
Cellular Signalling,
Год журнала:
2025,
Номер
127, С. 111589 - 111589
Опубликована: Янв. 5, 2025
Язык: Английский
Transcription factor specificity protein (SP) family in renal physiology and diseases
PeerJ,
Год журнала:
2025,
Номер
13, С. e18820 - e18820
Опубликована: Янв. 20, 2025
Dysregulated
specificity
proteins
(SPs),
members
of
the
C2H2
zinc-finger
family,
are
crucial
transcription
factors
(TFs)
with
implications
for
renal
physiology
and
diseases.
This
comprehensive
review
focuses
on
role
SP
family
members,
particularly
SP1
SP3,
in
pathology.
A
detailed
analysis
their
expression
cellular
localization
healthy
human
kidney
is
presented,
highlighting
involvement
fatty
acid
metabolism,
electrolyte
regulation,
synthesis
important
molecules.
The
also
delves
into
diverse
roles
SPs
various
diseases,
including
ischemia/reperfusion
injury,
diabetic
nephropathy,
interstitial
fibrosis,
lupus
nephritis,
elucidating
molecular
mechanisms
potential
as
therapeutic
targets.
further
discusses
pharmacological
modulation
its
treatment.
Our
findings
provide
a
understanding
health
disease,
offering
new
avenues
targeted
interventions
precision
medicine
nephrology.
Язык: Английский
The prognostic role of ACSL4 in postoperative adjuvant TACE-treated HCC: implications for therapeutic response and mechanistic insights
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2024,
Номер
43(1)
Опубликована: Ноя. 19, 2024
Abstract
Background
The
response
of
hepatocellular
carcinoma
(HCC)
to
transarterial
chemoembolization
(TACE)
treatment
and
its
underlying
mechanisms
remain
elusive.
This
study
investigates
the
role
enzymes
involved
in
fatty
acid
activation,
specifically
Acyl-CoA
synthetase
long
chain
4
(ACSL4),
HCC
patients
treated
with
postoperative
adjuvant
TACE
(PA-TACE)
nutrient-deprived
cells.
Methods
We
examined
expression
ACSL4
family
members
clinical
samples
cell
lines.
significance
ACSL4,
particularly
regarding
prognosis
PA-TACE,
was
assessed
using
two
independent
cohorts.
further
explored
glucose
starvation-induced
death
cells
xenograft
mouse
models.
Results
Among
members,
is
most
up-regulated
enzyme,
associated
poor
survival
patients,
post-recurrent
TACE-treated
a
Singapore
cohort.
essential
for
starvation,
rather
than
hypoxia
or
combination
doxorubicin
cisplatin.
ACSL4-mediated
arachidonic
(AA)
metabolism
supports
mitochondrial
β
-oxidation
energy
production.
CCAAT/enhancer
binding
protein
α
(CEBPA)
transcriptionally
regulates
by
3
motifs
(-623
-613,
-1197
-1187
-1745
-1735)
upstream
promoter
region,
enhancing
pro-survival
effects.
Furthermore,
canagliflozin
(Cana),
clinical-approved
drug
type
2
diabetes,
mimics
starvation
inhibits
growth
ACSL4-low
tumors.
Moreover,
high
CEBPA
expressions
correlate
increased
recurrence
susceptibility
after
PA-TACE
China-Guangxi
Conclusions
CEBPA-ACSL4
pathway
critical
protecting
from
death,
suggesting
that
could
serve
as
valuable
prognostic
indicators
potential
therapeutic
targets
context
HCC.
Graphical
first-line
intermediate-stage
unresectable
tumor
common
(PA)
treatment.
present
found
presence
are
more
resistant
TACE,
susceptible
relapse
poorer
survival.
Mechanically,
activation
conversion
into
AA-CoA,
which
promotes
lipid
anabolism
nutrition-replete
condition
catabolism
glucose-deplete
condition.
As
result,
ACSL4-high
cells,
restriction
(rather
chemotherapeutic
drugs),
can
donor
production
through
protect
membrane
impairment
vitro
vivo
.
In
addition,
activates
,
knockout
aborted
metabolism.
Язык: Английский
Regulation of Cancer Metastasis by PAK2
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13443 - 13443
Опубликована: Дек. 15, 2024
PAK2
is
a
serine-threonine
kinase
and
member
of
the
p21-activated
(PAK)
family.
activated
by
GTP-bound
rho
family
GTPases,
Rac,
Cdc42,
it
regulates
actin
dynamics,
cell
adhesion
to
extracellular
matrix,
motility.
In
various
types
cancers,
has
been
implicated
in
regulation
cancer
proliferation,
cycle,
apoptosis.
addition,
recent
studies
have
shown
that
plays
an
important
role
metastasis,
indicating
as
potential
therapeutic
target.
This
review
discusses
discoveries
on
functions
cancers.
A
better
understanding
mechanisms
function
will
facilitate
future
development
therapies.
Язык: Английский
PAK2 as a therapeutic target in cancer: Mechanisms, challenges, and future perspectives
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1880(1), С. 189246 - 189246
Опубликована: Дек. 16, 2024
Язык: Английский
Investigating the hub genes and genetic basis regulating fatty acid metabolictraits in chicken breast muscle based on combined genomic and transcriptomic approaches
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 2, 2024
Abstract
Background
The
composition
of
various
fatty
acids
in
meat
plays
a
crucial
role
the
evaluation
nutritional
indicators
poultry
and
human
health.
Fatty
acid
metabolic
can
more
accurately
reflect
status
its
acceptance
by
general
public.
In
this
study,
we
utilized
two
analytical
approaches,
Genome-Wide
Association
Study
(GWAS)
Weighted
Gene
Co-expression
Network
Analysis
(WGCNA),
to
elucidate
genetic
mechanisms
underlying
traits
chicken
breast
muscle.Initially,
GWAS
was
conducted
based
on
genotype
data
obtained
genotyping
sequencing
(GBS)
from
415
chickens
Gushi-Anka
F2
resource
population
phenotypic
33
metabolism
muscle.
Results
We
identified
total
291
significant
single
nucleotide
polymorphisms
(SNPs)
associated
with
content
12
types
such
as
C14:0/C12:0,
C18:0/C16:0,
C18:1/C18:0,
etc.,
which
were
mapped
chromosomes
(Chr)
1,
2,
3,
4,
5,
7,
9,
10.
The
most
SNP
Chr2:102,
676,
165
(
P
=
1.20E-06),
explained
2.33%
variation
polyunsaturated
(PUFA)/mono-unsaturated
(MUFA)
synthesis
pathway.
that
highest
Chr4:
30,
150,
765
(5.85%).
Interestingly,
signals
for
three
(C22:4/C18:3,
C20:3/C18:3,
C22:6/C18:3)
within
same
gene
interval
Chr
9
(Chr9:
5.75
-
8.99Mb).
Concurrently,
WGCNA
using
613
candidate
genes
linkage
disequilibrium
regions
aforementioned
SNPs,
well
transcriptome
values
muscle
Gujshi
periods,
13
hub
(
FIG4,
METTL4,
PLD4,
IDH1,
FH,
SDHA,
EHHADH,
AKT1,
PIK3CB,
LPIN2,
FUT9,
PAK2,
ACSL3)
finally
determined.
Further,
constructed
functional
networks
involving
these
deduced
potential
Conclusion
These
results
enhance
our
understanding
regulation
muscle,
providing
theoretical
basis
future
breeding
practices
targeting
traits.
Язык: Английский
[Ferroptosis inducer Erastin inhibits proliferation of liver cancer cells
PubMed,
Год журнала:
2024,
Номер
44(11), С. 2131 - 2136
Опубликована: Ноя. 20, 2024
To
investigate
the
expression
of
Acyl-CoA
synthetase
long-chain
family
member
4
(ACSL4)
in
liver
cancer
and
its
role
regulating
ferroptosis
proliferation
cells.
Язык: Английский