Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102544 - 102544
Опубликована: Окт. 1, 2024
Язык: Английский
Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер 169, С. 106021 - 106021
Опубликована: Янв. 16, 2025
Язык: Английский
Процитировано
1
Life, Год журнала: 2025, Номер 15(5), С. 762 - 762
Опубликована: Май 9, 2025
Fertility is a dynamic, multifactorial process governed by hormonal, immune, metabolic, and environmental factors. Recent evidence highlights the gut microbiota as key systemic regulator of reproductive health, with notable impacts on endometrial function, implantation, pregnancy maintenance, timing birth. This review examines gut–endometrial axis, focusing how microbial communities influence biology through molecular signaling pathways. We discuss modulatory roles microbial-derived metabolites—including short-chain fatty acids, bile tryptophan catabolites—in shaping immune tolerance, estrogen metabolism, epithelial integrity at uterine interface. Emphasis placed shared mechanisms such β-glucuronidase-mediated recycling, Toll-like receptor (TLR)-driven inflammation, Th17/Treg cell imbalance, translocation, which collectively implicate dysbiosis in etiology gynecological disorders including endometriosis, polycystic ovary syndrome (PCOS), recurrent implantation failure (RIF), preeclampsia (PE), preterm birth (PTB). Although most current remains correlational, emerging insights from metagenomic metabolomic profiling, along microbiota-depletion models Mendelian randomization studies, underscore biological significance gut-reproductive crosstalk. By integrating concepts microbiology, immunology, biology, this offers systems-level perspective host–microbiota interactions female fertility.
Язык: Английский
Процитировано
1
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Фев. 8, 2025
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Май 19, 2025
Short-chain fatty acids (SCFAs), the primary metabolites produced by microbial fermentation of dietary fibers in gut, have a key role protecting gut health. Increasing evidence indicates SCFAs can exert effects on distant tissues and organs beyond via blood circulation. Osteoarthritis (OA) is chronic inflammatory joint disease that severely diminishes physical function quality life. However, effective clinical treatments for OA remain elusive. Recent studies shown beneficial damaged joints OA. mitigate progression preserving intestinal barrier maintaining integrity cartilage subchondral bone, suggesting they substantial potential to be adjunctive treatment strategy This review described human body their cellular signaling mechanism, summarized multiple (especially butyrate, propionate, acetate) prevention regulating gut-joint axis, providing novel insights into promising applications.
Язык: Английский
Процитировано
0
Gut Microbes, Год журнала: 2025, Номер 17(1)
Опубликована: Май 20, 2025
Metabolic Dysfunction-Associated Steatotic Liver Disease(MASLD) is increasing in prevalence worldwide and has become the greatest potential risk for cirrhosis hepatocellular liver cancer. Currently, role of gut microbiota development MASLD a research hotspot. The can affect homeostasis microbiota, significant changes composition or abundance its metabolite abnormalities influence disease progression. regulation an important strategy novel target treatment with good prospects. In this paper, we summarize metabolites pathogenesis MASLD, describe preventive therapeutic efficacy as noninvasive marker to regulate based on "gut-hepatic axis", which will provide new ideas clinic.
Язык: Английский
Процитировано
0
Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102544 - 102544
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0