Genes, Год журнала: 2025, Номер 16(5), С. 498 - 498
Опубликована: Апрель 27, 2025
The global rise in obesity and its associated metabolic disorders underscores the need for a deeper investigation into their underlying molecular mechanisms. While genetic factors are well-established contributors, recent research has increasingly focused on epigenetic regulators, particularly N6-methyladenosine (m6A)-the most prevalent internal RNA modification eukaryotes. This post-transcriptional plays crucial role metabolism by regulating mRNA stability, splicing, nuclear export, translation efficiency. Notably, emerging evidence implicates m6A both adipogenesis dysregulation. In this review, we systematically examine three key dimensions: (1) mechanisms of modification, including writers, erasers, readers, obesity; (2) dysregulated patterns obesity-related pathologies, such as type 2 diabetes (T2D), insulin resistance, dysfunction-associated steatotic liver disease (MASLD), glycolysis cancer cells; (3) therapeutic potential targeting regulators. By critically assessing advancements, highlight m6A's dual sensor modulator, offering novel insights strategies combating syndromes.
Язык: Английский