Reproductive and nonreproductive actions of testosterone

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Establishing altitude-based coagulation reference ranges in Western Sichuan

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

The diagnosis and treatment of diseases in plateau regions should incorporate altitude, sex, age addition to hematological indicators from plain regions. This study analyzed coagulation results among individuals living at different altitudes the Western Sichuan Plateaus belonging sex groups examine patterns change determine normal ranges. By comparing changes healthy male female residents (< 40 years, 40–59 ≥ 60 years) Guza (1,400 m), Kangding (2,500 Luhuo (3,400 Litang (4,100 we association between age, sex. Under low temperature, hypoxia, other environment factors, varied altitudes, with some showing specific trends increasing altitude. Different sexes also exhibited results. clarified four Plateau effects on function. Normal ranges values were determined for providing a scientific basis healthcare this region.

Язык: Английский

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The intersection of the laboratory and transgender care

Critical Reviews in Clinical Laboratory Sciences, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Май 1, 2025

Transgender and gender diverse (TGD) individuals seeking affirming treatment are an increasing demographic in today's society; such treatments include hormonal surgical interventions aimed at alleviating dysphoria quality of life. A number diagnostic pathology tests provided to medical professionals with sex specific reference intervals (RIs) for interpretation, due physiological differences, organ size hormone levels example. These may be reported RIs that not appropriate, interpretation the professional can challenging. From laboratory perspective, there limitations Laboratory Information Management Systems (LIMS) ability these databases record both identifiers, as well reporting appropriate RIs. The use derived from transgender population is complex, studies generally have a low sample adults long established treatments. age individual undergoing therapy has decreased, Gonadotrophin Releasing Hormone analogues adds complexity. In this review, we will discuss current challenges perspectives regarding TGD population, derivation personalized or tests.

Язык: Английский

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Establishing altitude-based coagulation reference ranges in Western Sichuan

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 7, 2025

Язык: Английский

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Establishment of reference intervals for complete blood count in healthy adults at different altitudes on the Western Sichuan Plateau

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Май 21, 2025

A detailed reference range for complete blood count of healthy adults in the Western Sichuan Plateau region is unavailable. This study aimed to explore changes (CBC) across high-altitude regions Ganzi Prefecture, Province, establish altitude-specific intervals and improve diagnostic accuracy provide tailored clinical guidance residents these areas. CBC data from 3,485 individuals four altitudes-Guza (1,400 m), Lucheng (2,500 Luhuo (3,200 Litang (4,100 m)-were collected between January 2022 December 2023. The were analyzed by sex, altitude, age groups, their interactions intervals. indicators showed significant with increasing altitude. Red cell (RBC) count, hemoglobin (HGB), hematocrit (HCT), white (WBC) platelet (PLT) all significantly increased as altitude rose (p < 0.05). Males had higher RBC, WBC, PLT counts than females altitudes 0.05), except Litang, where HCT HGB differences sexes not With age, RBC HCT, HGB, WBC both sexes. Most population exceeded national intervals, males Guza Lucheng. established revealing variations age. These findings valuable insights improving disease diagnosis medical care residents.

Язык: Английский

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The Effect of Environmental Disasters on Endocrine Status, Hematology Parameters, Body Composition, and Physical Performance in Young Soccer Players: A Case Study of the Aral Sea Region

Life, Год журнала: 2023, Номер 13(7), С. 1503 - 1503

Опубликована: Июль 3, 2023

The Aral Sea region (Uzbekistan) is infamous because of the ecological disaster characterized by disappearance due to excessive uncontrolled water intake for agriculture needs. A new desert occurrence, soil and climate aridization led pesticide toxic metals environment pollution. impact environmental conditions in some areas Uzbekistan on health soccer players not as noticeable as, example, effectiveness training, so it widely discussed scientific papers. aim present study was features endocrine status, hematology parameters (e.g., red blood cells (RBC) hemoglobin (Hb)), their influence body composition physical fitness performance local young territory disaster. involved 60 male aged from 18 22 years. Participants were divided into two groups: experimental group (EG), which consisted 30 living region, control (CG), included players, natives ecologically favorable Uzbekistan. All volunteers had anthropometric measurements, concentrations insulin-like growth factor-1 (IGF-1), total testosterone (TT), estradiol (E2), cortisol (C), RBC, Hb count. Moreover, Yo-Yo Intermittent Recovery Test Level 1 (YYIRT1) professional skills tests such dribbling shuttle test (DSt) goal accuracy (GAt) assessed. When comparing CG EG group, observed that exhibited statistically significantly reduced levels TT E2 (p < 0.05). No significant statistical difference between groups terms IGF-1 C > Regarding hematological parameters, Hb, Ht, mean corpuscular volume (MCV) found be lower compared with distance covered YYIR1 within Additionally, determined there no DSt GAt values Lastly, differences characteristics (diameters, skinfold, somatotype profile) showed changes evaluated might result complex endocrine-disrupting chemicals, content high region. results obtained may help monitor athletes an environmentally unfriendly environment.

Язык: Английский

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Association between hemoglobin-to-red blood cell distribution width ratio and chronic kidney disease: A cross sectional study

Medicine, Год журнала: 2024, Номер 103(45), С. e40224 - e40224

Опубликована: Ноя. 8, 2024

The hemoglobin-to-red blood cell distribution width ratio (HRR) is recognized as a novel prognostic biomarker; however, studies exploring its relationship with chronic kidney disease (CKD) are scarce. This study used data from the National Health and Nutrition Examination Survey database 2005 to 2018. analysis included individuals aged ≥ 20 years who had complete HRR CKD data. Weighted univariate multivariate logistic regression analyses were assess association between prevalence. Additionally, restricted cubic spline subgroup conducted for further validation. Ultimately, 19,426 participants in this study. After adjusting confounders, revealed negative (OR = 0.35, 95% CI 0.22–0.56). In addition, linear CKD, higher levels of associated lower prevalence CKD. that was stronger male population. negatively adult population US. potential indicator assessing provides rationale personalized management.

Язык: Английский

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Testosterone and Erythrocyte Lifespan

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Июнь 24, 2024

Abstract Context Endogenous and exogenous androgens increase circulating erythrocytes hemoglobin but their effects on erythrocyte lifespan is not known. Objective To investigate androgen immature mature in humans mice using novel nonradioactive minimally invasive methods. Design Human was estimated alveolar carbon monoxide concentration blood Levitt's formula hypogonadal or transgender men before up to 18 weeks after commencing testosterone (T) treatment. Erythrocyte receptor knockout wild-type T DHT treatment of intact females orchidectomized males vivo biotin labelling surface epitopes for reticulocytes (Ter119+CD71+) 2 markers (CD45–, Ter119+CD71–) monitoring disappearance rate by flow cytometry. Results Before treatment, had marked reduction compared with controls. increased at 6 returned pretreatment levels weeks, whereas serum were remaining elevated weeks. In mice, higher (but reticulocyte) neither orchidectomy nor inactivation significantly influenced reticulocyte lifespan. Conclusion We conclude that have reduced acute androgen-induced may contribute the well-known erythropoietic androgens, longer term require further investigation determine how much they increases hemoglobin.

Язык: Английский

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Testosterone in prevention and treatment of type 2 diabetes in men: Focus on recent randomized controlled trials

Annals of the New York Academy of Sciences, Год журнала: 2024, Номер 1538(1), С. 45 - 55

Опубликована: Июль 22, 2024

Abstract In epidemiological studies, lowered serum testosterone concentrations are common in men with obesity, prediabetes, and established type 2 diabetes (T2D). also predicts a future risk of T2D men. Administration consistently reduces fat mass increases skeletal muscle mass—body compositional changes expected to be metabolically favorable. T2D, the effects treatment on glycemic measures inconsistent. Irrespective baseline concentration prediabetes or newly diagnosed early‐onset prescribed conjunction lifestyle program has been reported reduce by 40% after years, suggesting that either is required facilitate benefit and/or more favorable glycemia early evolution onset disease. The durability longer‐term safety have not established. Therefore, studies before can recommended for prevention at elevated who do hypogonadism due an disease hypothalamic‐pituitary‐testicular axis.

Язык: Английский

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Initiating male contraception methods

Andrology, Год журнала: 2024, Номер 12(7), С. 1529 - 1534

Опубликована: Июль 29, 2024

Abstract Non‐surgical (reversible) male contraception methods, when approved for general clinical application, should be made available to all interested men aged 18 50 years in good health regardless of their semen parameters. In the preliminary workup, a complete personal and family history aimed at identifying specific conditions that may potentially increase risks adverse effects (associated with testosterone replacement) is advisable but or andrological examination not required, unless indicated by history. Baseline body weight, blood pressure haemoglobin recorded purpose future monitoring. While benefits vasectomy have been well established, appropriately nuanced patient counselling assessment are essential ensuring satisfactory outcome vasectomy.

Язык: Английский

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