A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing

Bioactive Materials, Год журнала: 2021, Номер 15, С. 203 - 213

Опубликована: Дек. 20, 2021

Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated performance are urgently desired. Herein, we reported composite antibacterial hydrogel PDA-PAM/Mg2+ that shows excellent self-healing and tissue adhesive property, photothermal functions for accelerating healing. gel was composed polyacrylamide (PAM), polydopamine (PDA), magnesium (Mg2+) prepared via two-step procedure: an alkali-induced dopamine pre-polymerization followed radical polymerization adhesiveness Mg2+-synergized activity, inducing survival rate 5.29% S. aureus 7.06% E. coli after near infrared light irradiation. further demonstrated efficient bacteria inhibition, enhanced collagen deposition in full-thickness skin defect rat model. Together, presents dressing adhesion, healing, functions.

Язык: Английский

---

Coordination-Driven Self-Assembly Strategy-Activated Cu Single-Atom Nanozymes for Catalytic Tumor-Specific Therapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(7), С. 4279 - 4293

Опубликована: Фев. 6, 2023

How to optimize the enzyme-like catalytic activity of nanozymes improve their applicability has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven self-assembly strategy activate polyvinylpyrrolidone (PVP)-modified Cu single-atom MoOx-Cu-Cys (denoted as MCCP SAzymes) aiming at tumor-specific therapy. The single atom content can be rationally modulated 10.10 wt %, which activates catalase (CAT)-like MoOx nanoparticles catalyze decomposition H2O2 in acidic microenvironments increase O2 production. Excitingly, maximized CAT-like efficiency is 138-fold higher than that typical MnO2 and exhibits 14.3-fold affinity natural catalase, demonstrated by steady-state kinetics. We verify well-defined l-Cys-Cu···O active sites match through l-Cys bridge-accelerated electron transfer from Cys-Cu disclosed density functional theory calculations. Simultaneously, high loading atoms also enable generation •OH via Fenton-like reaction. Moreover, under X-ray irradiation, converts 1O2 for cascading radiodynamic therapy, thereby facilitating multiple reactive oxygen species (ROS) radiosensitization achieve substantial antitumor.

Язык: Английский

---

Defect engineering in nanozymes

Materials Today, Год журнала: 2021, Номер 52, С. 327 - 347

Опубликована: Ноя. 29, 2021

Язык: Английский

---

Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Фев. 11, 2023

Nanozymes, a class of nanomaterials mimicking the function enzymes, have aroused much attention as candidate in diverse fields with arbitrarily tunable features owing to diversity crystalline nanostructures, composition, and surface configurations. However, uncertainty their active sites lower intrinsic deficiencies nanomaterial-initiated catalysis compared natural enzymes promote pursuing alternatives by imitating biological centers. Single-atom nanozymes (SAzymes) maximize atom utilization well-defined structure, providing an important bridge investigate mechanism relationship between structure catalytic activity. They risen new burgeoning alternative enzyme from vitro bioanalytical tool vivo therapy flexible atomic engineering structure. Here, focus is mainly on three parts. First, detailed overview single-atom catalyst synthesis strategies including bottom-up top-down approaches given. Then, according structural feature nanocatalysts, influence factors such central metal atom, coordination number, heteroatom doping, metal-support interaction are discussed representative applications (including antibacterial/antiviral performance, cancer therapy, biosensing) highlighted. In end, future perspective challenge facing demonstrated.

Язык: Английский

---

Injectable Adhesive Self-Healing Multiple-Dynamic-Bond Crosslinked Hydrogel with Photothermal Antibacterial Activity for Infected Wound Healing

Chemistry of Materials, Год журнала: 2022, Номер 34(6), С. 2655 - 2671

Опубликована: Март 10, 2022

The development of multifunctional injectable adhesive hydrogels with self-healing capacity, shape adaptability, on-demand removability, and excellent photothermal antibacterial activity to promote bacteria-infected wound healing is highly recommended in practical applications. In this work, an multiple-dynamic-bond crosslinked hydrogel was formed by a network dynamic borate/didiol interactions, hydrogen bonding, Schiff base bond. introduction Mussel-inspired catechol groups into the could endow tissues properties, adhere well skin under water good adaptability bent twisted states. mechanical properties improved through interactions catechol-modified crosslinking at low cost easy preparation, be removed without second damage wound. Moreover, polydopamine nanoparticles (PDA NPs) were introduced reactions between quinone group on PDA NPs primary amine glycol chitosan (GC), resulting efficient uniformly dispersed hydrogel. And illustrated cytocompatibility hemocompatibility. Finally, they injected fully fill irregular wounds significantly reducing inflammatory response, accelerating collagen deposition, promoting blood vessel reconstruction. Therefore, demonstrated their superiority serving as dressings for treating

Язык: Английский

---

Bimetallic oxide Cu1.5Mn1.5O4 cage-like frame nanospheres with triple enzyme-like activities for bacterial-infected wound therapy

Nano Today, Год журнала: 2022, Номер 43, С. 101380 - 101380

Опубликована: Янв. 22, 2022

Язык: Английский

---

Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria‐Killing

Advanced Functional Materials, Год журнала: 2022, Номер 32(20)

Опубликована: Фев. 9, 2022

Abstract Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal effects, resulting dramatically increased peroxidase‐like activity when exposed 808 nm light. Both experimental results theoretical calculations show that remarkable catalytic performance CuS@GDY due unique hierarchical structure, narrow bandgap GDY nanowalls, effect CuS nanocages, fast interfacial electron transfer dynamics, carbon vacancies CuS@GDY. plasmonic exhibits rapid, efficient, broad‐spectrum antibacterial ( > 99.999%) against diverse pathogens (methicillin‐resistant Staphylococcus aureus , Escherichia coli ). study not only sheds light mechanism nanozyme‐/photocatalysis coupling process, also opens up new avenue for engineering NIR driven nanozymes rapid synergistic photo‐enhanced therapy.

Язык: Английский

---

Spherical mesoporous Fe-N-C single-atom nanozyme for photothermal and catalytic synergistic antibacterial therapy

Journal of Colloid and Interface Science, Год журнала: 2021, Номер 606, С. 826 - 836

Опубликована: Авг. 14, 2021

Язык: Английский

---

Recent advances in multifunctional nanomaterials for photothermal-enhanced Fenton-based chemodynamic tumor therapy

Materials Today Bio, Год журнала: 2022, Номер 13, С. 100197 - 100197

Опубликована: Янв. 1, 2022

Photothermal (PT)-enhanced Fenton-based chemodynamic therapy (CDT) has attracted a significant amount of research attention over the last five years as highly effective, safe, and tumor-specific nanomedicine-based therapy. CDT is new emerging nanocatalyst-based therapeutic strategy for in situ treatment tumors via Fenton reaction or Fenton-like reaction, which got fast progress recent because its high specificity activation by endogenous substances. A variety multifunctional nanomaterials such metal-, metal oxide-, metal-sulfide-based nanocatalysts have been designed constructed to trigger within tumor microenvironment (TME) generate cytotoxic hydroxyl radicals (•OH), efficient killing cells. However, still required enhance curative outcomes minimize side effects. Specifically, efficiency certain CDTs hindered TME, including low levels hydrogen peroxide (H2O2), overexpression reduced glutathione (GSH), catalytic efficacy reactions (pH 5.6-6.8), makes it difficult completely cure cancer using monotherapy. For this reason, photothermal (PTT) utilized combination with efficacy. More interestingly, heating during PTT not only causes damage cells but can also accelerate generation •OH reactions, thus enhancing efficacy, providing more effective when compared Currently, synergistic PT-enhanced both PT properties made enormous theranostics. there no comprehensive review on subject published date. In review, we first summarize treatment. We then discuss potential challenges future development nanocatalytic clinical application.

Язык: Английский

---

Emerging carbon-supported single-atom catalysts for biomedical applications

Matter, Год журнала: 2022, Номер 5(10), С. 3341 - 3374

Опубликована: Окт. 1, 2022

Язык: Английский

---