Critical Reviews in Microbiology,
Год журнала:
2024,
Номер
unknown, С. 1 - 18
Опубликована: Ноя. 20, 2024
Extracellular
vesicles
(EVs)
are
cell
membrane-derived
structures
between
20-400
nm
in
size.
In
bacteria,
EVs
play
a
crucial
role
molecule
secretion,
wall
biogenesis,
cell-cell
communication,
biofilm
development,
and
host-pathogen
interactions.
Despite
these
increasing
reports
of
bacterial-derived
vesicles,
there
remains
limited
number
studies
that
summarize
oral
bacterial
EVs,
their
cargo,
main
biological
functions.
Therefore,
the
aim
this
review
is
to
present
latest
research
on
bacteria-derived
how
they
can
modulate
various
physiological
pathological
processes
cavity,
including
pathogenesis
highly
relevant
diseases
such
as
dental
caries
periodontitis
systemic
complications.
Overall,
caries-associated
bacteria
(such
Membranes,
Год журнала:
2022,
Номер
12(12), С. 1244 - 1244
Опубликована: Дек. 8, 2022
Extracellular
vesicles
(EV)
are
membrane
surrounded
by
a
lipid
bilayer
and
include
microvesicles,
apoptotic
bodies,
exosomes,
exomeres.
Exosome-encapsulated
microRNAs
(miRNAs)
released
from
cancer
cells
involved
in
the
proliferation
metastasis
of
tumor
via
angiogenesis.
On
other
hand,
mesenchymal
stem
cell
(MSC)
therapy,
which
is
being
employed
regenerative
medicine
owing
to
ability
MSCs
differentiate
into
various
cells,
due
humoral
factors,
including
messenger
RNA
(mRNA),
miRNAs,
proteins,
lipids,
encapsulated
exosomes
derived
transplanted
cells.
New
treatments
that
advocate
cell-free
therapy
using
MSC-derived
will
significantly
improve
clinical
practice.
Therefore,
highly
purified
perform
their
original
functions
desirable.
In
this
review,
we
summarized
advances
purification,
modification,
application
EVs
as
novel
strategies
treat
some
diseases.
Pathogens and Immunity,
Год журнала:
2024,
Номер
9(1), С. 56 - 90
Опубликована: Апрель 23, 2024
There
are
a
growing
number
of
studies
linking
the
composition
human
microbiome
to
disease
states
and
treatment
responses,
especially
in
context
cancer.
This
has
raised
significant
interest
developing
microbes
microbial
products
as
cancer
immunotherapeutics
that
mimic
or
recapitulate
beneficial
effects
host-microbe
interactions.
Bacterial
extracellular
vesicles
(bEVs)
nano-sized,
membrane-bound
particles
secreted
by
essentially
all
bacteria
species
contain
diverse
bioactive
cargo
producing
cell.
They
have
fundamental
role
facilitating
interactions
among
cells
same
species,
different
even
with
multicellular
host
organisms
colonization
(microbiome)
infection.
The
interaction
bEVs
immune
system
been
studied
extensively
infection
suggests
bEV
depend
largely
on
species.
thus
provide
functional
diversity,
while
also
being
nonreplicative,
having
inherent
cell-targeting
qualities,
potentially
overcoming
natural
barriers.
These
characteristics
make
them
highly
appealing
for
development
immunotherapeutics.
Both
natively
engineered
now
investigated
their
application
immunotherapeutics,
vaccines,
drug
delivery
vehicles,
combinations
above,
promising
early
results.
both
intrinsic
immunomodulatory
properties
ability
be
modified
could
harnessed
next-generation
microbe-inspired
therapies.
Nonetheless,
there
remain
major
outstanding
questions
regarding
how
observed
preclinical
effectiveness
will
translate
from
murine
models
primates,
humans
particular.
Moreover,
research
into
pharmacology,
toxicology,
mass
manufacturing
this
potential
novel
therapeutic
platform
is
still
at
stages.
In
review,
we
highlight
breadth
cells,
focusing
immunologic
main
mechanism
action
currently
development.
We
review
literature
ongoing
efforts
develop
variety
bacterial
therapy
finally
discuss
overcome
challenges
clinical
translation.
Non-coding RNA Research,
Год журнала:
2023,
Номер
9(1), С. 236 - 252
Опубликована: Дек. 15, 2023
Gastrointestinal
cancers
are
a
huge
worldwide
health
concern,
which
includes
wide
variety
of
digestive
tract
cancers.
Circular
RNAs
(circRNAs),
kind
non-coding
RNA
(ncRNAs),
family
single-stranded,
covalently
closed
that
have
become
recognized
as
crucial
gene
expression
regulators,
having
an
impact
on
several
cellular
functions
in
cancer
biology.
The
gut
microbiome,
consists
different
bacteria,
actively
contributes
to
the
regulation
host
immunity,
inflammation,
and
metabolism.
CircRNAs
microbiome
interact
significantly
greatly
affect
growth
GI
cancer.
Several
studies
focus
complex
circRNAs
microbiota
cancers,
including
esophageal
cancer,
colorectal
gastric
hepatocellular
pancreatic
It
also
emphasizes
how
changed
circRNA
profiles
pathways
connected
malignancy
well
hallmarks
gastrointestinal
Furthermore,
been
recommended
biological
markers
for
therapeutic
targets
diagnostic
prognostic
purposes.
Targeting
treatment
is
being
continued
study.
Despite
significant
initiatives,
connection
between
emergence
remains
poorly
understood.
In
this
study,
we
will
go
over
most
recent
emphasize
key
roles
progression
options.
order
create
effective
therapies
plan
future
therapy,
it
important
comprehend
mechanisms
microbiota.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 7, 2023
Colorectal
cancer
(CRC)
is
a
common
malignant
digestive
tract
tumor
in
colorectal
regions.
Considerable
evidence
now
shows
that
the
gut
microbiota
have
essential
roles
CRC
occurrence
and
development.
Most
Gram-negative
bacteria
release
outer
membrane
vesicles
(OMVs)
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 9, 2024
The
activation
of
ferroptosis
presents
a
versatile
strategy
for
enhancing
the
antitumor
immune
responses
in
cancer
therapy.
However,
developing
inducers
that
combine
high
biocompatibility
and
therapeutic
efficiency
remains
challenging.
In
this
study,
we
propose
novel
approach
using
biological
nanoparticles
derived
from
outer
membrane
vesicles
(OMVs)
Escherichia
coli
tumor
treatment,
aiming
to
activate
stimulate
responses.
Specifically,
functionalize
OMVs
by
anchoring
them
with
ferrous
ions
via
electrostatic
interactions
loading
STING
agonist-4,
followed
tumor-targeting
DSPE-PEG-FA
decoration,
henceforth
referred
as
OMV/SaFeFA.
endows
peroxidase-like
activity,
capable
inducing
cellular
lipid
peroxidation
catalyzing
H
Applied Materials Today,
Год журнала:
2024,
Номер
40, С. 102395 - 102395
Опубликована: Авг. 28, 2024
The
prevalence
of
cancer
on
a
global
scale
has
necessitated
the
development
various
therapeutic
approaches.
However,
effectiveness
and
safety
existing
methods
often
face
some
limitations.
Nanotechnology
emerged
as
solution,
enabling
design
nanosystems
that
can
effectively
deliver
drugs.
These
address
challenges
such
low
drug
stability
solubility,
well
lack
tumor
targetability.
While
nanomaterials
offer
advantages,
certain
nanoparticles
have
their
own
limitations,
which
prompted
researchers
to
explore
innovative
delivery
systems.
One
promising
avenue
is
use
extracellular
vesicles
(EVs),
are
natural
secreted
by
cells.
EVs
possess
biocompatibility,
stability,
targeting
capabilities,
making
them
ideal
candidates
for
carriers.
still
remain
in
this
field.
include
limited
production
yield,
complexity,
inefficient
cargo
loading,
controlled
release
To
overcome
these
challenges,
been
employing
engineering
techniques
modify
structures
EVs,
enhancing
intrinsic
properties.
Surface
modification
hybrid
systems
combine
with
other
shown
potential
addressing
This
review
focuses
landscape
crucial
role
therapeutics
diagnosis.
It
begins
exploring
biological
functions
properties
EVs.
Additionally,
introduces
strategies
isolating
shedding
light
methodologies
used
harvest
minute
entities.
Finally,
highlights
biomedical
applications
bioengineering
treatment.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Май 21, 2024
Gastric
Cancer
(GC)
is
a
prevalent
malignancy
globally
and
the
third
leading
cause
of
cancer-related
deaths.
Recent
researches
focused
on
correlation
between
intestinal
flora
GC.
Studies
indicate
that
bacteria
can
influence
development
gastrointestinal
tumors
by
releasing
bacterial
extracellular
vesicles
(BEVs).
The
Tumor
microenvironment
(TME)
plays
an
important
role
in
tumor
survival,
with
interaction
flora,
BEVs,
TME
directly
impacting
progression.
Moreover,
recent
studies
have
demonstrated
microflora
BEVs
modify
to
enhance
effectiveness
antitumor
drugs.
This
review
article
provides
overview
comparison
biological
targets
through
which
microbiome
regulates
TME,
laying
groundwork
for
potential
applications
diagnosis,
treatment,
prognosis.
Journal of Extracellular Vesicles,
Год журнала:
2025,
Номер
14(5)
Опубликована: Май 1, 2025
ABSTRACT
Bacterial
extracellular
vesicles
(EVs)
are
natural
reservoirs
of
biological
active
substances.
They
exhibit
promising
application
in
developing
bioproducts
such
as
vaccine,
drug‐delivery
system
and
anticancer
agent.
However,
the
low
yield
naturally
secreted
EVs
during
bacterial
growth
is
a
bottleneck
factor
that
restricts
EV
applications.
In
this
study,
we
showed
sub‐minimum
inhibitory
concentration
(MIC)
β‐lactams
boosted
production
various
Staphylococcus
aureus
strains.
The
expression
penicillin‐binding
protein
(PBP)
genes
increased
after
β‐lactam
treatment,
inactivation
alternative
PBPs
promoted
secretion
S.
.
We
also
demonstrated
sub‐MIC
via
reactive
oxygen
species
(ROS)‐dependent
pathway.
Deletion
redundant
pbp
enhanced
oxacillin
(OXA)‐stimulated
ROS
levels.
Transcriptomic
lipidomic
analyses
revealed
OXA‐induced
triggered
lipid
metabolic
reprogramming
Particularly,
peroxidation
(LPO)
biosynthesis
phosphatidic
acid
(PA)
lipoteichoic
(LTA)
contributed
to
generation.
Furthermore,
OXA
treatment
altered
diversity
EV‐loaded
proteins.
OXA‐treated
∆
agr
/OXA
induced
stronger
Dengue
EDIII‐specific
antibodies
BALB/c
mice
than
did
EVs.
Overall,
study
provided
mechanic
insights
into
β‐lactam‐promoted
,
highlighted
potential
strategies
prepare
for
