Laser
powder
bed
fusion
(L-PBF)
of
WE43
magnesium
alloy
has
a
promising
application
prospect
in
the
fields
lightweight
parts
and
biodegradable
implants.
Grain
refinement
these
components
is
expected
for
high
strength
controlled
biodegradation,
however,
grain
structure
sensitive
to
composition
processing.
L-PBF
exhibited
significant
diversity
on
microstructure
properties
with
fluctuation
composition,
influencing
mechanism
remained
unclear.
In
this
study,
samples
were
fabricated
formation
quality
using
four
different
powders,
which
content
Nd
Zr
purposely
adjusted.
Their
microstructure,
tensile
corrosion
resistance
characterized.
specimens
composed
fine
equiaxed
grains
obtained
from
Mg-3.56Y-2.45Nd-1.14Gd-0.40Zr
powder,
achieving
ultimate
316
MPa
elongation
15%.
With
minor
decrease
content,
was
still
range
present
standards
WE43,
respectively
abnormal
growth
coarse
columnar
grains,
leading
tremendous
deterioration
mechanical
resistance.
During
multiple
layers
solidification,
promoted
columnar-to-equiaxed
transition
generated
finer
while
exerted
pinning
effect
heat
affected
zone
keep
growth.
The
results
firstly
demonstrate
influence
change
alloying
elements
performance,
indicate
that
stricter
compositional
standard
necessary
achieve
reliable
process.
Journal of Biomedical Materials Research Part A,
Год журнала:
2024,
Номер
112(12), С. 2136 - 2148
Опубликована: Июнь 20, 2024
Abstract
Bioabsorbable
Mg
wire‐reinforced
poly‐lactic
acid
(PLA)
matrix
composites
are
potential
candidate
for
load‐bearing
orthopedic
implants
offering
tailorable
mechanical
and
degradation
properties
by
stacking
sequence,
volume
fraction
surface
modification
of
wires.
In
this
study,
we
investigated
the
cytocompatibility,
cell‐material
interaction,
bone
differentiation
behavior
MC3T3‐E1
pre‐osteoblast
cells
medical‐grade
PLA,
Mg/PLA,
PEO‐Mg/PLA
(having
PEO
on
wires)
composites.
MTT
live/dead
assay
showed
excellent
biocompatibility
both
while
interaction
analysis
revealed
that
were
able
to
adhere
proliferate
Cells
longitudinal
a
high
uniform
cell
density
those
transversal
surfaces
initially
avoided
regions
but
later
migrated
back
after
formation
passivation
layer.
Bone
tests
in
extracts
PLA
initiate
process
as
osteogenesis‐related
gene
expressions,
alkaline
phosphatase
protein
quantity,
calcium
mineralization
increased
7
14
days
culture.
Interestingly,
response
composite
was
found
be
similar
proving
its
superiority
over
Mg/PLA
composite.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
11(1), С. 485 - 492
Опубликована: Дек. 2, 2024
The
development
of
Mg
and
its
alloys
as
bone
screws
has
garnered
significant
attention
due
to
their
exceptional
biocompatibility
unique
biodegradability.
Notably,
the
controlled
release
Mg2+
ions
during
degradation
can
positively
influence
fracture
healing.
advantages
raise
appeal
for
application
in
tissue
engineering.
However,
porous
scaffolds,
while
offering
high
surface
areas,
face
challenges
maintaining
slow
rates
preserving
interconnectivity,
which
are
crucial
features
ingrowth.
To
address
these
issues,
this
study
introduces
a
highly
interconnected
hierarchical
scaffold
investigates
behavior
within
bioreactor,
simulating
body
fluid
flow
mimic
vivo
performance
at
different
implantation
sites.
focus
lies
on
elucidating
evolution
structure,
particularly
impact
interconnectivity.
Our
findings
reveal
that
initial
interconnectivity
is
significantly
influenced
by
rate.
dynamic
modulates
transport
byproducts
deposition
patterns.
At
lower
rates,
accumulate
pores,
leading
formation
substantial
deposits
directly
reduce
porosity.
Specifically,
after
42
days,
porosities
decreased
68.80
±
2.31,
58.52
2.53,
41.25
2.82%
2.0,
1.0,
0.5
mL/min,
respectively.
This
porosity
reduction
pore
space
occlusion
sequentially
hinder
magnitude
could
be
used
evaluate
ability
microarchitecture
maintain
Meanwhile,
long-term
potentially
revealed
structural
integrity
loss
from
original
design
degraded
structure
rates.
present
work
might
bring
valuable
insight
into
strut
characterization
methods
progress
high-performance
engineering
scaffold.
Laser
powder
bed
fusion
(L-PBF)
of
WE43
magnesium
alloy
has
a
promising
application
prospect
in
the
fields
lightweight
parts
and
biodegradable
implants.
Grain
refinement
these
components
is
expected
for
high
strength
controlled
biodegradation,
however,
grain
structure
sensitive
to
composition
processing.
L-PBF
exhibited
significant
diversity
on
microstructure
properties
with
fluctuation
composition,
influencing
mechanism
remained
unclear.
In
this
study,
samples
were
fabricated
formation
quality
using
four
different
powders,
which
content
Nd
Zr
purposely
adjusted.
Their
microstructure,
tensile
corrosion
resistance
characterized.
specimens
composed
fine
equiaxed
grains
obtained
from
Mg-3.56Y-2.45Nd-1.14Gd-0.40Zr
powder,
achieving
ultimate
316
MPa
elongation
15%.
With
minor
decrease
content,
was
still
range
present
standards
WE43,
respectively
abnormal
growth
coarse
columnar
grains,
leading
tremendous
deterioration
mechanical
resistance.
During
multiple
layers
solidification,
promoted
columnar-to-equiaxed
transition
generated
finer
while
exerted
pinning
effect
heat
affected
zone
keep
growth.
The
results
firstly
demonstrate
influence
change
alloying
elements
performance,
indicate
that
stricter
compositional
standard
necessary
achieve
reliable
process.
