Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101104 - 101104
Опубликована: Май 27, 2024
Clinical
treatment
of
diabetic
refractory
ulcers
is
impeded
by
chronic
inflammation
and
cell
dysfunction
associated
with
wound
healing.
The
significant
clinical
application
bFGF
in
healing
limited
its
instability
vivo.
Sulfur
has
been
applied
for
the
skin
diseases
clinic
antibiosis.
We
previously
found
that
sulfur
incorporation
improves
ability
selenium
nanoparticles
to
accelerate
healing,
yet
toxicity
still
poses
a
risk
application.
To
obtain
materials
high
pro-regeneration
activity
low
toxicity,
we
explored
mechanism
which
selenium-sulfur
aid
via
RNA-Seq
designed
nanoparticle
called
Nano-S@bFGF,
was
constructed
from
bFGF.
As
expected,
Nano-S@bFGF
not
only
regenerated
zebrafish
tail
fins
promoted
but
also
repair
mice
profitable
safety
profile.
Mechanistically,
successfully
coactivated
FGFR
Hippo
signalling
pathways
regulate
Briefly,
reported
here
provides
an
efficient
feasible
method
synthesis
bioactive
nanosulfur
In
long
term,
our
results
reinvigorated
efforts
discover
more
peculiar
unique
biofunctions
great
variety
human
diseases.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 16, 2024
Diabetic
vascular
complications
attract
increased
attention
due
to
their
high
morbidity,
mortality
and
disability
rate.
Comprehensive
in-depth
exploration
of
the
etiology
pathogenesis
diabetic
is
important
for
diagnosis
treatment.
Endothelial
extracellular
vesicles
(EVs)
serve
as
potential
intercellular
communicators,
transmitting
biological
information
from
donor
cell
recipient
cell,
exerting
both
harmful
beneficial
effects
on
function.
EVs
are
new
diagnostic
therapeutic
targets
biomarkers
in
complications.
This
review
summarizes
biogenesis
release
endothelial
EVs,
well
isolation
characterization
methods,
discusses
role
maintenance
homeostasis
along
with
contributions
dysfunction.
Finally,
article
illustrates
impact
evaluates
tools
markers
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 24, 2024
Exosomes
carry
proteins,
metabolites,
nucleic
acids
and
lipids
from
their
parent
cell
of
origin.
They
are
derived
cells
through
exocytosis,
ingested
by
target
cells,
can
transfer
biological
signals
between
local
or
distant
cells.
Therefore,
exosomes
often
modified
in
reaction
to
pathological
processes,
including
infection,
cancer,
cardiovascular
diseases
response
metabolic
perturbations
such
as
obesity
diabetes,
all
which
involve
a
significant
inflammatory
aspect.
Here,
we
discuss
how
immune
cell-derived
origin
neutrophils,
T
lymphocytes,
macrophages
impact
on
the
reprogramming
diabetes
associated
complications.
Besides,
stem
immunomodulatory
properties
anti-inflammation
effect
also
reviewed.
Moreover,
As
an
important
addition
previous
reviews,
describes
promising
directions
involving
engineered
well
current
challenges
clinical
applications
diabetic
therapy.
Further
research
will
explore
potential
translational
medicine
provide
new
avenues
for
development
effective
diagnostics
therapeutic
strategies
immunoregulation
diabetes.
Materials Today Bio,
Год журнала:
2024,
Номер
26, С. 101104 - 101104
Опубликована: Май 27, 2024
Clinical
treatment
of
diabetic
refractory
ulcers
is
impeded
by
chronic
inflammation
and
cell
dysfunction
associated
with
wound
healing.
The
significant
clinical
application
bFGF
in
healing
limited
its
instability
vivo.
Sulfur
has
been
applied
for
the
skin
diseases
clinic
antibiosis.
We
previously
found
that
sulfur
incorporation
improves
ability
selenium
nanoparticles
to
accelerate
healing,
yet
toxicity
still
poses
a
risk
application.
To
obtain
materials
high
pro-regeneration
activity
low
toxicity,
we
explored
mechanism
which
selenium-sulfur
aid
via
RNA-Seq
designed
nanoparticle
called
Nano-S@bFGF,
was
constructed
from
bFGF.
As
expected,
Nano-S@bFGF
not
only
regenerated
zebrafish
tail
fins
promoted
but
also
repair
mice
profitable
safety
profile.
Mechanistically,
successfully
coactivated
FGFR
Hippo
signalling
pathways
regulate
Briefly,
reported
here
provides
an
efficient
feasible
method
synthesis
bioactive
nanosulfur
In
long
term,
our
results
reinvigorated
efforts
discover
more
peculiar
unique
biofunctions
great
variety
human
diseases.
