Polymer Engineering and Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
Diabetes
is
a
chronic
condition
that
will
affect
diabetic
patients
throughout
their
lives.
Glucose‐sensitive
hydrogels
offer
significant
advantages
in
diabetes
management
due
to
excellent
biocompatibility
and
ability
regulate
blood
glucose
levels.
To
improve
the
sensitivity
of
these
under
physiological
conditions,
we
developed
glucose‐responsive
acrylic
graphene
oxide
(GOM)/nanocomposite
using
novel
method.
This
was
achieved
by
creating
GOM‐poly(3‐acrylamidophenylboronic
acid‐
N
,
‐dimethylacrylamide‐co‐acrylamide)
(AAPBA‐DMAA‐co‐AAm)
microgels
through
emulsion
polymerization
GOM,
dimethyl
acrylamide
(DMAA),
(AAm),
3‐acrylamidophenylboronic
acid
(AAPBA).
Subsequently,
GOM/nanocomposite
with
rapid
responsiveness
were
free
radical
as
micro‐crosslinkers
GOM
an
additive.
Their
composition,
surface
morphology,
mechanical
properties
characterized
Fourier
transform
infrared,
XRD,
scanning
electron
microscope,
modular
compact
rheometer.
The
effectively
addressed
issue
sluggish
kinetics
typical
monomer‐based
hydrogels.
At
pH
7.3
concentration
20
mM,
GOM‐poly(AAPBA‐DMAA‐co‐AAm)
reached
swelling
equilibrium
18
min
degree
(SD)
15.93%.
1.0%wt
accomplished
SD
20.31%
40
min,
making
clear
enrichments
response
speed
strength.
Using
metformin
hydrochloride
model
drug,
at
10
cumulative
release
rates
within
24
h
51.92%
61.78%,
respectively.
increased
73.95%
82.07%,
study
introduces
effective
method
for
providing
microgel
composite
hydrogels,
which
can
be
widely
used
biomedical
fields,
including
drug
delivery,
tissue
engineering,
wound
healing,
so
on.
Highlights
modified
prepare
propylene‐based
double
bonds.
oxide/nanocomposite
enhance
speed.
High
rate
controlled
release.
Materials,
Год журнала:
2024,
Номер
17(10), С. 2439 - 2439
Опубликована: Май 18, 2024
This
comprehensive
review
delves
into
the
world
of
hyaluronic
acid
(HA)
hydrogels,
exploring
their
creation,
characteristics,
research
methodologies,
and
uses.
HA
hydrogels
stand
out
among
natural
polysaccharides
due
to
distinct
features.
Their
exceptional
biocompatibility
makes
them
a
top
choice
for
diverse
biomedical
purposes,
with
great
ability
coexist
harmoniously
living
cells
tissues.
Furthermore,
biodegradability
permits
gradual
breakdown
by
bodily
enzymes,
enabling
creation
temporary
frameworks
tissue
engineering
endeavors.
Additionally,
since
is
vital
component
extracellular
matrix
(ECM)
in
numerous
tissues,
can
replicate
ECM's
structure
functions.
mimicry
pivotal
applications
providing
an
ideal
setting
cellular
growth
maturation.
Various
cross-linking
techniques
like
chemical,
physical,
enzymatic,
hybrid
methods
impact
mechanical
strength,
swelling
capacity,
degradation
speed
hydrogels.
Assessment
tools
such
as
rheological
analysis,
electron
microscopy,
spectroscopy,
tests,
studies
are
employed
examine
attributes.
HA-based
feature
prominently
engineering,
drug
distribution,
wound
recovery,
ophthalmology,
cartilage
mending.
Crafting
enables
production
biomaterials
sought-after
qualities,
offering
avenues
advancements
realm
biomedicine.
Applied Sciences,
Год журнала:
2025,
Номер
15(2), С. 536 - 536
Опубликована: Янв. 9, 2025
Hyaluronan
(HA)
is
a
ubiquitous
macromolecule
in
the
human
body
with
remarkable
structure
and
function.
HA
presents
key
role
several
biological
processes
mammals.
The
synthesis/catabolism
of
critical
pathologies
has
been
used
as
marker
for
prognosis
cancers.
Among
its
physiological
roles,
wound
healing
applications.
This
review
reports
many
latest
developments
hyaluronan
derivatives
research,
preclinical,
published
clinical
trials
healing.
An
adequate
physico-chemical
characterization
identification
selected
properties
prepared
material
are
mandatory.
Moreover,
cytotoxicity
evaluation
effects
vitro
using
standardized
protocols
required
preclinical.
Finally,
to
choose
vivo
models
testing
efficacy
requested.
Unfortunately,
still
not
well
understood.
Therefore,
an
overview
HA-based
products
provided
discussed.
Several
ways
chemical
modification
were
evaluated.
this
focuses
on
containing
HA,
novel
developments,
gaps,
limitations
current
state
art.
Polymers,
Год журнала:
2025,
Номер
17(2), С. 162 - 162
Опубликована: Янв. 10, 2025
The
problem
of
antibiotic
abuse
and
drug
resistance
is
becoming
increasingly
serious.
In
recent
years,
polydopamine
(PDA)
nanoparticles
have
been
recognized
as
a
potential
antimicrobial
material
for
photothermal
therapy
(PTT)
due
to
their
excellent
conversion
efficiency
unique
ability.
PDA
capable
rapidly
converting
light
energy
into
heat
under
near-infrared
(NIR)
irradiation
kill
bacteria
efficiently.
order
solve
the
PDA's
tendency
aggregate
precipitate,
this
study
improved
its
stability
by
grafting
hyaluronic
acid
(HA)
onto
surface
PDA.
Using
dopamine
raw
materials,
was
grafted
via
self-polymerization
Michael
addition
reactions
alkaline
conditions
obtain
PDA-HA-modified
nanoparticles.
We
confirmed
successful
scanning
electron
microscopy
(SEM),
Fourier
infrared
spectroscopy
(FTIR),
nuclear
magnetic
hydrogen
(¹H
NMR),
ultraviolet-visible
(UV-vis),
Raman
(Raman),
dynamic
scattering
(DLS)
methods.
Scanning
(SEM)
used
observe
morphology
nanostructure
providing
information
on
size
distribution
materials.
Near-infrared
performance
experiments
showed
that
temperature
PDA-HA
solution
increased
irradiation,
demonstrating
an
performance.
Antimicrobial
properties
were
assessed
colony
counting
method,
typical
Gram-positive
S.
aureus
Gram-negative
E.
coli
selected
model
strains.
experimental
groups
tested
dark
irradiation.
PDA/HA
significant
NIR
resulting
in
rapid
increase
surrounding
level
sufficient
bacteria.
Under
exhibited
100%
efficacy
against
both
coli,
while
limited
conditions.
This
indicates
antibacterial
activity
highly
dependent
activation.
