Pharmaceutical Biology, Год журнала: 2024, Номер 62(1), С. 818 - 832
Опубликована: Окт. 30, 2024
Ulcerative colitis (UC) is an intractable inflammatory bowel disease that threatens the health of patients. The limited availability therapeutic strategies makes it imperative to explore more efficient and safer drugs.
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125428 - 125428
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161208 - 161208
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101636 - 101636
Опубликована: Март 5, 2025
Developing hydrogels with wet-adhesion, immunomodulation and regenerative repair capabilities in intestinal remains a formidable challenge. In the present study, development of an anti-inflammatory, wet-adhesive, decellularized extracellular matrix hydrogel produced using three-dimensional (3D) -printing technology is presented. This hydrogel, which integrates gelatin dopamine, was demonstrated to display excellent wet-adhesion properties, fully harnessing outstanding potential small-intestine matrix. Furthermore, integration Prussian Blue nanozymes imparted significant anti-inflammatory antioxidant properties. Through modulating macrophage polarization, not only found enhance tissue repair, but also substantially mitigate inflammation. vivo experiments (namely, histopathological analyses rat model) that this able effectively regeneration healing models damage. conclusion, through utilization 3D-printing technology, study has shown precise manufacturing customization various shapes sizes defects may be executed, thereby providing innovative strategy for repair. advanced therefore been hold promise as bioadhesive both emergency therapy.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 18, 2025
Язык: Английский
Процитировано
0
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Inflammation and oxidative stress are important features of traumatic ulcerative colitis (UC). Turmeric has been used as a dietary functional ingredient for its potent anti-inflammatory effects in UC therapy. However, practical effectiveness is hindered by limited reactive oxygen species (ROS) elimination properties. To address this, we constructed unique treatment agent growing cerium oxide (CeO2) nanocrystals on the membranes turmeric-derived nanovesicles (TNVs), named TNV-Ce. The resulted TNV-Ce could suppress inflammation exhibit exceptional ROS-scavenging activity, which was validated both lipopolysaccharide-induced macrophages dextran sulfate sodium salt-induced chronic mouse model. Following oral administration, significantly accumulated at inflamed sites, effectively eliminating ROS inhibiting pro-inflammatory cytokines synergistic action against UC.
Язык: Английский
Процитировано
0
Chinese Medical Journal, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Nanozymes are a distinct category of nanomaterials that exhibit catalytic properties resembling those enzymes such as peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), and glutathione (GPx). derived from Chinese herbal medicines the functions their enzyme mimics, while retaining specific medicinal herb (termed "herbzymes"). These nanozymes can be categorized into three main groups based on method synthesis: carbon dot nanozymes, polyphenol-metal extract nanozymes. The reported activities herbzymes include POD, SOD, CAT, GPx. This review presents an overview potential applications introduces novel concept herbzymes, provides comprehensive classification synthesis, discusses recent advances in biomedical applications. Furthermore, we also discuss significance research including primary challenges faced future development directions.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Сен. 20, 2024
To realize effective and long-term synergistic therapy of ulcerative colitis (UC) with probiotics, we developed gastrointestinal self-adaptive nutrient self-sufficient
Язык: Английский
Процитировано
3
Food Bioscience, Год журнала: 2024, Номер unknown, С. 105490 - 105490
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
3
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 15(1), С. 592 - 610
Опубликована: Авг. 26, 2024
Ischemia-reperfusion (I/R) injury following skin flap transplantation is a critical factor leading to necrosis and transplant failure. Antagonizing inflammatory responses oxidative stress are regarded as crucial targets for mitigating reperfusion enhancing survival. In this study, caffeic acid-vanadium metal polyphenol nanoparticles (CA-V NPs) were prepared the treatment of ischemia reperfusion. This study was conducted using one-step method prepare new types CA-V NPs with uniform sizes stable structures. vitro, exhibited CAT-like SOD-like activities could effectively scavenge ROS, generate oxygen, alleviate stress. H2O2-induced cellular model, reduced ROS levels inhibited apoptosis through XIAP/Caspase-3 pathway. inflammation model induced by LPS combined IFN-γ, reprogrammed macrophage polarization toward M2 phenotype reducing expression chemokines CCL4 CXCL2. addition, animal experiments have shown that can in tissues, inhibit apoptosis, promote angiogenesis, ultimately improve survival rate flaps. provide target strategy I/R injury.
Язык: Английский
Процитировано
2
Carbohydrate Polymers, Год журнала: 2024, Номер 350, С. 123063 - 123063
Опубликована: Ноя. 26, 2024
Язык: Английский
Процитировано
2