Enhanced antitumor efficacy of nanostructured lipid carrier co-loaded with docetaxel and 5-fluorouracil for targeted gastric cancer therapy
Medical Oncology,
Год журнала:
2025,
Номер
42(2)
Опубликована: Янв. 22, 2025
Язык: Английский
NIR-Triggered Programmable Nanomotor with H2S and NO Generation for Cascading Oncotherapy by Three-Pronged Reinforcing ICD
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101540 - 101540
Опубликована: Фев. 3, 2025
Язык: Английский
Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Silica-induced ROS in alveolar macrophages and its role on the formation of pulmonary fibrosis via polarizing macrophages into M2 phenotype: A review
Shu‐ling Du,
Yu‐ting Zhou,
Huijie Hu
и другие.
Toxicology Mechanisms and Methods,
Год журнала:
2024,
Номер
unknown, С. 1 - 12
Опубликована: Сен. 3, 2024
Alveolar
macrophages
(AMs),
the
first
line
against
invasion
of
foreign
invaders,
play
a
predominant
role
in
pathogenesis
silicosis.
Studies
have
shown
that
inhaled
silica
dust
is
recognized
and
engulfed
by
AMs,
resulting
production
large
amounts
silica-induced
reactive
oxygen
species
(ROS),
including
particle-derived
ROS
macrophage-derived
ROS.
These
change
microenvironment
AMs
where
macrophage
phenotype
stimulated
to
swift
from
M0
M1
and/or
M2,
ultimately
emerge
as
M2
trigger
This
complex
process
accompanied
various
molecular
biological
events.
Unfortunately,
detailed
processes
mechanisms
not
been
systematically
described.
In
this
review,
we
introduce
induced
AMs.
Then,
describe
mechanism
M2-type
polarization
caused
Finally,
review
pulmonary
fibrosis
polarized
We
conclude
initiate
fibrotic
silicosis
inducing
into
phenotype,
targeted
intervention
can
reprogram
ameliorate
Язык: Английский
Interactions between tumor-associated macrophages and regulated cell death: therapeutic implications in immuno-oncology
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Ноя. 7, 2024
Tumor-associated
macrophages
(TAMs)
play
a
pivotal
role
in
sculpting
the
tumor
microenvironment
and
influencing
cancer
progression,
particularly
through
their
interactions
with
various
forms
of
regulated
cell
death
(RCD),
including
apoptosis,
pyroptosis,
ferroptosis,
necroptosis.
This
review
examines
interplay
between
TAMs
these
RCD
pathways,
exploring
mechanisms
which
they
interact
to
promote
growth
advancement.
We
examine
underlying
intricate
interactions,
emphasizing
importance
progression
treatment.
Moreover,
we
present
potential
therapeutic
strategies
for
targeting
manipulating
enhance
anti-tumor
responses.
These
encompass
reprogramming
TAMs,
inhibiting
recruitment,
selectively
eliminating
them
functions,
alongside
modulating
pathways
amplify
immune
insights
offer
novel
perspective
on
biology
provide
foundation
development
more
efficacious
therapies.
Язык: Английский
Multi-omics and Machine Learning-driven CD8+ T Cell Heterogeneity Score for Prognosis and Personalized Therapy Outcomes Prediction in Head and Neck Squamous Cell Carcinoma
Molecular Therapy — Nucleic Acids,
Год журнала:
2024,
Номер
36(1), С. 102413 - 102413
Опубликована: Дек. 5, 2024
Язык: Английский
Emerging nanomedicines for macrophage-mediated cancer therapy
Biomaterials,
Год журнала:
2024,
Номер
316, С. 123028 - 123028
Опубликована: Дек. 15, 2024
Язык: Английский
Integrating Photothermal, Photodynamic, and Chemodynamic Therapies: The Innovative Design Based on Copper Sulfide Nanoparticles for Enhanced Tumor Therapy
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
8(1), С. 676 - 687
Опубликована: Дек. 30, 2024
A
multifunctional
nanoplatform
integrating
multiple
therapeutic
functions
may
be
an
effective
strategy
to
realize
satisfactory
efficacy
in
the
treatment
of
tumors.
However,
there
is
still
a
certain
challenge
agents
into
single
formulation
using
simple
method
due
variations
their
properties.
In
this
work,
CuS-ICG@PDA-FA
nanoparticles
(CIPF
NPs)
with
excellent
ability
produce
reactive
oxygen
species
and
photothermal
conversion
performance
are
fabricated
by
gentle
method.
Hollow
mesoporous
copper
sulfide
(HMCuS
not
only
have
loading
but
also
can
cause
highly
efficient
Fenton-like
reaction
for
chemodynamic
therapy
(CDT).
The
loaded
photosensitizer
indocyanine
green
(ICG)
imparts
photodynamic
properties
NPs,
which
turn
enhances
stability
ICG.
polydopamine
(PDA)
coating
improves
biocompatibility
NPs
creates
conditions
surface
modification
folic
acid.
FA-coated
show
precise
targeting
tumor
cells.
results
cellular
uptake
assay
demonstrate
that
CIPF
enter
cells
through
endocytic
pathway.
Lysosome
colocalization
escape
experiments
prove
possess
good
lysosomal
under
irradiation
NIR.
Both
vitro
vivo
antitumor
studies
reveal
photothermal/photodynamic/chemodynamic
therapy.
construction
high-performance
offers
valuable
insights
design
sulfide-based
combined
cancer
theranostics.
Язык: Английский