BOIMPY Scaffold: Accessing Ultrahigh Molar Extinction Coefficient AIEgen for SWIR Imaging‐Guided Photothermal Cancer Ablation

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Abstract Despite the extensive reporting of versatile aggregation‐induced emission luminogens (AIEgens), boosting their molar extinction coefficient (MEC, ε ≈ 10 3 –10 4 M −1 cm ) remains a formidable challenge, which poses significant obstacle to achieving ceiling output performance. In this work, an “aggrandizing absorption reservoir” approach is proposed designing AIEgens with remarkable photons‐harvesting ability, ultimately enlarging its performance in terms short‐wave infrared (SWIR, 900–1700 nm) and photothermal effect. For first time, (bis‐(borondifluoride)‐8‐imidazodipyrromethene) (BOIMPY) unit, provides sufficient rigidity strong electron‐withdrawing ability by employing benzimidazole as bridging ligand binding two BF 2 units, utilized fabricate novel AIEgen (TPEB) that exhibits ultrahigh MEC up 1.29 × 5 at 828 nm. To best knowledge, highest reported among near‐infrared absorption. Thanks photon‐harvesting TPEB fluorescence SWIR region good The as‐prepared NPs are successfully applied for imaging‐guided antitumor therapy. guideline biomedical applications.

Язык: Английский

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Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Photothermal therapy (PTT), as an innovative optical tumor treatment strategy, is characterized by its minimal invasiveness, high selectivity, long‐lasting efficacy, and safety, has attracted widespread attention. However, in order to effectively kill cancer cells, a higher local temperature very necessary, which inevitably results severe stress responses cell death, thereby triggering harmful inflammation. Additionally, achieving effective controlled release of drugs the microenvironment reduce systemic side effects still major challenge. Herein, intelligent nanoplatform first reported, featured sulfide iron (FeS) nanosheets core, loaded with perfluorohexane (PFH), skillfully coated polydopamine (PDA). It can serve generator reactive oxygen species (ROS) induce ferroptosis, further intensifying PTT, ROS eliminator normal tissue control undesired inflammatory response during differential strategy between surrounding tissue. Meanwhile, combination ultrasound‐targeted microbubble destruction (UTMD) technology significantly enhanced penetration drug. Overall, delivery FeS/PFH@PDA combined UTMD achieve precise efficient synergistic for tumors demonstrate outstanding ultrasound MR dual‐mode imaging performance.

Язык: Английский

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A Bright Organic Fluorophore for Accurate Measurement of the Relative Quantum Yield in the NIR‐II Window

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Organic dyes with photoluminescence in the second near-infrared window (NIR-II, 1000-1700 nm) are promising for bioimaging and optoelectronic devices. Photoluminescence quantum yield (PLQY) is a direct measure of their performance. Integrating sphere technology effective determining absolute PLQY. However, low PLQY values most NIR-II organic fluorophores lead to significant measurement errors. Therefore, common method determination relative approach using spectrometer standard reference like IR-26. Although enables precise calculation ratio between sample reference, specific value IR-26 not clearly defined reported range from 0.05% 0.50%. Such deviation can cause errors measurements. In this study, it that bright fluorophore called TPE-BBT exhibits high 3.94% THF, which be accurately measured commercially available integrating sphere. Using as standard, 1,2-dichloroethane IR-1061 dichloromethane determined 0.0284% 0.182%, respectively. It hoped reliable will unify evaluation criteria fluorophores.

Язык: Английский

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Reengineering of Donor–Acceptor–Donor Structured Near-Infrared II Aggregation-Induced Emission Luminogens for Starving-Photothermal Antitumor and Inhibition of Lung Metastasis

ACS Nano, Год журнала: 2024, Номер 18(43), С. 30069 - 30083

Опубликована: Окт. 18, 2024

Electron acceptor possessing strong electron-withdrawing ability and exceptional stability is crucial for developing donor–acceptor–donor (D-A-D) structured aggregation-induced emission luminogens (AIEgens) with second near-infrared (NIR-II) emission. Although 6,7-diphenyl-[1,2,5] thiadiazolo [3,4-g] quinoxaline (PTQ) benzobisthiadiazole (BBT) are widely employed as NIR-II building blocks, they still suffer from limited capacity or inadequate chemo-stability under alkaline conditions. Herein, a boron difluoride formazanate (BFF) utilized to construct AIEgen, which exhibits better overall performance in terms of compared the PTQ- BBT-derived fluorophores. With finely tuned intramolecular motions D–A interaction strength, TPE-BFF simultaneously high molar extinction coefficient (ε= 4.31 × 104 M–1cm–1), (Φ = 0.49%) photothermal effect (η 58.5%), well stability. Thanks these merits, thermosensitive nanoparticles constructed by integrating antiglycolytic agent 2-deoxy-d-glucose (2DG) successfully imaging-guided antitumor lung metastasis regulating glycolysis reducing ATP-dependent heat shock proteins. Combining experimental results theoretical calculations, BFF proves be an outstanding electron design versatile AIEgens. Overall, this study offers promising alternative multifunctional AIEgens biomedical applications.

Язык: Английский

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Hydrogel Local Drug Delivery Systems for Postsurgical Management of Tumors: Status Quo and Perspectives

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101308 - 101308

Опубликована: Окт. 24, 2024

Surgery is one of the primary treatments for solid tumors. However, incomplete resection tumor cells and immunosuppressive microenvironment make issue postsurgical recurrence a great challenge. Furthermore, wide range requirements, including ensuring effective hemostasis, implementing prophylactic measures against infection, promoting wound healing, were also raised in management To fulfill these demands, multiple hydrogel local drug delivery systems (HLDDS) developed recently. These HLDDS are expected to offer numerous advantages tumors, such as achieving high concentrations at lesion, efficient surgical microcavities, mitigating systemic side effects, addressing diverse demand. Thus, this review, detailed discussion demands tumors provided. And current publication trend on analyzed discussed. Then, applications different types HLDDS,

Язык: Английский

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Supramolecular Gels With Controllable Degradation for Suppressing Tumor Recurrence and Relieving Postoperative Pain

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

ABSTRACT Postoperative pain and tumor recurrence are critical challenges following malignant resection. To address these issues, we developed a supramolecular gel delivery system loaded with ropivacaine microcrystals (RopC Gel). Using PEG400 as the solvent, successfully screened identified matrix materials capable of forming hydrogels through heating–cooling process. By strategically leveraging hydrophilic hydrophobic properties matrix, controlled its mechanical strength degradation rate by adjusting ratio to components, resulting in degradable, injectable, self‐healing system. In both rat plantar incision mouse resection models, RopC Gel provided long‐lasting analgesia for up 5 days. Notably, tumor‐resected mice treated demonstrated extended survival slower progression. Further vitro vivo experiments revealed that affects mitochondrial function promoting accumulation reactive oxygen species cells, inducing pyroptosis, stimulating immunogenic cell death (ICD), activating anti‐tumor immune responses. This work offers an innovative solution postoperative management. Additionally, controllable outlined this study provide efficient strategy release multiple drugs, potential widespread clinical applications.

Язык: Английский

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Microenvironment‐Responsive Injectable Thermosensitive Hydrogel Incorporating Nanozymes for Synergistic Breast Cancer Therapy and Postsurgical Adjuvant Treatment

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Abstract Tumor recurrence and wound infection present significant challenges to patient recovery following surgery, underscoring the need for effective therapeutic strategies improve prognosis by mitigating these complications. This study introduces novel synthesis methods honeycomb‐like CuMnOx nanozymes CuO 2 nanoflowers with multienzymatic activity pH‐responsive properties. The enzymatic activities of can be regulated pH changes in tumor or microenvironments, while overcome limitation insufficient endogenous H O release ROS weakly acidic conditions. To realize their synergistic effects, nanozymes, along photothermal agent IR820, are co‐assembled into low‐melting point agarose solution, forming a thermosensitive nanozyme‐based hydrogel (CuMnOx@CuO @IR820 hydrogel, CMCI Gel), which facilitates controlled drug delivery exerts enhanced efficiency under low‐temperature therapy (LTPTT, <48 °C). In vitro vivo studies demonstrated that Gel effectively ablated cells range bacteria, including drug‐resistant bacteria like MRSA . Furthermore, it reduces inflammation, promotes vascular regeneration collagen deposition, accelerates healing. injectability thermosensitivity allow localized treatment, minimizing systemic side effects. Overall, benefits highlight as promising adjunctive prevent postsurgery infection.

Язык: Английский

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Organic Radiosensitizer with Aggregation-Induced Emission Characteristics for Tumor Ablation through Synergistic Apoptosis and Immunogenic Cell Death

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Inspired by the clinical application of thermotherapy to promote efficacy radiotherapy, this study demonstrates multimodal diagnostic pure organic nanoparticles in combined treatment tumors through imaging and photothermal properties. The developed demonstrated unique properties multiple functionalities, including excellent photostability thermostability, strong fluorescence emission near-infrared-II (NIR-II) region, extremely high conversion efficiency, good biocompatibility, significant radiosensitizing properties, effective tumor site accumulation. In vitro vivo evaluations that these are ideal candidates for synergistic radiotherapy guided NIR-II fluorescence, NIR-I photoacoustic, trimodal imaging. They act as radiosensitizers alleviating hypoxic microenvironment, modulating cell cycle, inducing apoptosis immunogenic death during which may provide a potential approach tumors.

Язык: Английский

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Therapeutic application of nanosystems-based metalloptosis for enhanced tumor radiotherapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 536, С. 216666 - 216666

Опубликована: Апрель 10, 2025

Язык: Английский

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Mechanisms of the FLASH effect: current insights and advances

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Май 9, 2025

Radiotherapy is a fundamental tool in cancer treatment, utilized over 60% of patients during their treatment course. While conventional radiotherapy effective, it has limitations, including prolonged durations, which extend patient discomfort, and toxicity to surrounding healthy tissues. FLASH (FLASH-RT), an innovative approach using ultra-high-dose-rate irradiation, shown potential selectively sparing normal tissues while maintaining unaltered tumor control. However, the precise mechanisms underlying this “FLASH effect” remain unclear. This mini-review explores key hypotheses, oxygen depletion, radical-radical interactions, mitochondrial preservation, differential DNA damage repair, immune modulation. Oxygen levels significantly affect tissue response radiation by promoting radical recombination, preserving function, differentially activating repair pathways versus extent depletion contributes effect remains debated. Additionally, FLASH-RT may modulate response, reducing inflammation cell function. To further enhance its therapeutic potential, increasingly being combined with complementary strategies such as radioprotectors, immunomodulators, nanotechnology platforms. These combinations aim amplify control toxicity, potentially overcoming current limitations. Despite promising preclinical evidence, exact clinical applicability require investigation. Addressing these gaps crucial for optimizing translating into improved outcomes patients. Continued research essential harness full benefits effect, offering paradigm shift oncology.

Язык: Английский

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