Remodeling Tumor Microenvironment Using Prodrug nMOFs for Synergistic Cancer Therapy DOI Creative Commons
Jun-Liang Dong,

Jin-Dong Ding,

Shuang Luo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Abstract Metal-organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (DCCMH) using metformin (Met) α-cyano-4-hydroxycinnamic acid (CHCA) ligands coordination self-assembly with Cu2+, followed by loading of DOX surface modification HA. Upon internalization cells, DCCMH releases CHCA, Met, response high levels GSH-H2O2 within the tumor microenvironment (TME); Cu2+ depletes GSH generates Cu+ that subsequently catalyzes H2O2 hydroxyl radical through Fenton reaction; CHCA induces further decrease intracellular pH promotes reactions inhibiting lactate efflux; Met up-regulates tyrosine kinase activity enhances chemotherapy DOX. With abilities synergistically combine chemo/chemodynamic remodel TME, nMOFs inhibit murine hepatoma effectively. This study presents feasible strategy fabricating which capable remodeling TME improve efficacy synergistic therapy.

Язык: Английский

Remodeling tumor microenvironment using prodrug nMOFs for synergistic cancer therapy DOI Creative Commons
Jun-Liang Dong,

Jin-Dong Ding,

Shuang Luo

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 19, 2025

Metal–organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (nMOFs, named DCCMH) using metformin (Met) α-cyano-4-hydroxycinnamic acid (CHCA) ligands coordination self-assembly with CuCl2, followed by loading of doxorubicin (DOX) surface modification hyaluronic (HA). Upon internalization cells, DCCMH releases Cu2+/+, CHCA, Met, DOX response high levels glutathione (GSH) hydrogen peroxide (H2O2) within the tumor microenvironment (TME); Cu+ catalyzes conversion H2O2 ·OH via Fenton reaction while it was oxidized Cu2+, which subsequently further de-consumed GSH; CHCA induces decrease intracellular pH promotes reactions inhibiting lactate efflux; Met up-regulates tyrosine kinase activity enhances chemotherapy DOX. With ability synergistically combine chemo/chemodynamic (CT/CDT) remodel TME, NPs inhibit murine hepatoma effectively. This study presents feasible strategy fabricating nMOFs capable remodeling TME improve efficacy through synergistic therapy.

Язык: Английский

Процитировано

1
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy DOI
Zhen Liu, Wei Hu, Yingying Cai

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 690, С. 137332 - 137332

Опубликована: Март 14, 2025

Язык: Английский

Процитировано

0
Scalable solvothermal preparation of microwave-responsive Janus nanocarrier for targeted drug delivery and hyperthermia DOI

Yuhai He,

Qiuhua Wu,

Yi Teng

и другие.

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102638 - 102638

Опубликована: Март 20, 2025

Язык: Английский

Процитировано

0
Nanozyme-based therapeutic strategies for rheumatoid arthritis DOI

Jucong Zhang,

Chenxi Wang,

Xiaochuan Wu

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 716 - 734

Опубликована: Дек. 3, 2024

Язык: Английский

Процитировано

1
Remodeling Tumor Microenvironment Using Prodrug nMOFs for Synergistic Cancer Therapy DOI Creative Commons
Jun-Liang Dong,

Jin-Dong Ding,

Shuang Luo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Abstract Metal-organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (DCCMH) using metformin (Met) α-cyano-4-hydroxycinnamic acid (CHCA) ligands coordination self-assembly with Cu2+, followed by loading of DOX surface modification HA. Upon internalization cells, DCCMH releases CHCA, Met, response high levels GSH-H2O2 within the tumor microenvironment (TME); Cu2+ depletes GSH generates Cu+ that subsequently catalyzes H2O2 hydroxyl radical through Fenton reaction; CHCA induces further decrease intracellular pH promotes reactions inhibiting lactate efflux; Met up-regulates tyrosine kinase activity enhances chemotherapy DOX. With abilities synergistically combine chemo/chemodynamic remodel TME, nMOFs inhibit murine hepatoma effectively. This study presents feasible strategy fabricating which capable remodeling TME improve efficacy synergistic therapy.

Язык: Английский

Процитировано

0