Dual dynamic bonds enable biocompatible polyurethane hydrogels with superior toughness, fatigue and puncture resistance, pH-reversibility, and room-temperature self-healability
Polymer,
Год журнала:
2025,
Номер
unknown, С. 128381 - 128381
Опубликована: Апрель 1, 2025
Язык: Английский
Minimalistic Implant for Percutaneous Magnetic Hyperthermia-Based Combination Therapy of Hepatocellular Carcinoma
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Percutaneous
local
thermal
therapy,
containing
radio
frequency
and
microwave
ablation,
is
widely
utilized
in
the
clinical
management
of
hepatocellular
carcinoma
(HCC)
due
to
its
minimal
invasiveness
favorable
therapeutic
outcomes.
However,
further
development
limited
by
a
prolonged
ablation
duration
risk
excessive
heating.
Magnetic
hyperthermia
therapy
(MHT)
provides
new
perspective
for
percutaneous
tumor
superior
tissue
penetration
capability
safety.
Herein,
an
iron
foam-agarose
gel-drug
(IF-Aga-drug)
implant
prepared
using
minimalistic
method
combination
HCC.
The
excellent
conductivity
IF
endows
it
with
strong
heating
owing
eddy
current
loss
alternating
magnetic
field
(AMF),
while
abundant
pores
provide
ample
space
drug
loading.
Agarose
gel
imparts
platform
universal
efficient
drug-loading
capacity
controlled
drug-release
that
responsive
hyperthermia.
Doxorubicin
(DOX)
as
representative
construct
IF-Aga-DOX
implant,
which
successfully
employed
ultrasound-guided,
hyperthermia-based
chemotherapy
orthotopic
HCC
rabbits
under
ultralow-power
intensities
(Happl·fappl
=
2.25
×
108
A
m-1
s-1).
developed
IF-Aga-drug
offers
convenient
versatile
strategy
therapy.
Язык: Английский
Intraocular Injectable Hydrogels for the Delivery of Cells and Nanoparticles
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101767 - 101767
Опубликована: Апрель 1, 2025
Язык: Английский
Scaffolds Functionalized with Matrix Metalloproteinase-Responsive Release of Mirna for Synergistic Magnetic Hyperthermia and Sensitizing Chemotherapy of Drug-Tolerant Breast Cancer
Опубликована: Янв. 1, 2024
Язык: Английский
Arginine-solubilized lipoic acid-induced β-sheets of silk fibroin-strengthened hydrogel for postoperative rehabilitation of breast cancer
Bioactive Materials,
Год журнала:
2024,
Номер
40, С. 667 - 682
Опубликована: Авг. 23, 2024
Breast
cancer
is
the
most
common
among
women
worldwide,
and
adjuvant
radiotherapy
(RT)
following
tumor
removal
one
of
commonly
used
treatments
for
breast
cancer.
However,
high
risk
recurrence
inevitable
radiation
skin
injury
after
RT
remain
fatal
problems,
seriously
challenging
patient's
postoperative
rehabilitation.
Herein,
a
multifunctional
poly
(lipoic
acid)-based
hydrogel
constructed
through
one-step
heating
mixture
α-lipoic
acid
(LA)/arginine
(Arg)/silk
fibroin
(SF),
without
introducing
any
non-natural
molecules.
The
multiple
synergistic
interactions
LA,
Arg,
SF
not
only
enhance
solubilization
LA
in
aqueous
systems
but
also
stabilize
poly(lipoic
acid)
strong
salt
bridge
hydrogen
bonds
ionic
bonds.
Intriguingly,
LA-based
surfactant
induced
β-sheet
transformation
can
further
modulate
bulk
strength
hydrogel.
Regulating
content
hydrogels
allows
efficient
control
bioactivity
enables
evolution
from
injectable
forms
to
adhesive
patches.
Based
on
different
biological
activities
hydrogels,
they
be
implanted
internally
or
applied
externally
mice's
skin,
achieving
simultaneous
prevention
post-surgery
assistance
treating
radiation-induced
damage
radiotherapy.
Язык: Английский
Iron-based magnetic nanocomplexes for combined chemodynamic and photothermal cancer therapy through enhanced ferroptosis
Biomaterials Advances,
Год журнала:
2024,
Номер
166, С. 214046 - 214046
Опубликована: Сен. 15, 2024
Язык: Английский
Temperature-sensitive hydrogel inhibits VEGFA-dependent neovascularization in atherosclerosis progression
Science China Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 13, 2024
Язык: Английский
Scaffolds functionalized with matrix metalloproteinase-responsive release of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of drug-tolerant breast cancer
Bioactive Materials,
Год журнала:
2024,
Номер
44, С. 205 - 219
Опубликована: Окт. 19, 2024
Язык: Английский