Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip
ACS Nano,
Год журнала:
2024,
Номер
18(45), С. 31569 - 31585
Опубликована: Ноя. 1, 2024
Exposure
to
micro-
and
nanoplastics
(MNPs)
has
been
implicated
in
potential
cardiotoxicity.
However,
vitro
models
based
on
cardiomyocyte
cell
lines
lack
crucial
cardiac
characteristics,
while
interspecies
differences
animal
compromise
the
reliability
of
conclusions.
In
addition,
current
research
predominantly
focused
single-time
point
exposures
MNPs,
neglecting
comparative
analyses
injury
across
early
late
stages.
Moreover,
there
remains
a
large
gap
understanding
susceptibility
MNPs
under
pathological
conditions.
To
address
these
limitations,
this
study
integrated
organoids
(COs)
organ-on-a-chip
(OoC)
technology
develop
organoid-on-a-chip
(COoC),
which
was
validated
for
cardiotoxicity
evaluation
through
multiple
dimensions.
Based
COoC,
we
conducted
dynamic
observation
damage
caused
by
short-
long-term
exposure
polystyrene
(PS-NPs).
Oxidative
stress,
inflammation,
disruption
calcium
ion
homeostasis,
mitochondrial
dysfunction
were
confirmed
as
mechanisms
PS-NP-induced
events
stages,
fibrosis
emerged
prominent
feature
Notably,
low-dose
exacerbated
myocardial
infarction
symptoms
states,
despite
no
significant
shown
healthy
models.
conclusion,
findings
further
deepened
our
cardiotoxic
effects
introduced
promising
platform
assessing
Язык: Английский
Use of Brain Death Recipients in Xenotransplantation: A Double‐Edged Sword
Xenotransplantation,
Год журнала:
2025,
Номер
32(1)
Опубликована: Янв. 1, 2025
Organ
transplants
are
used
to
treat
many
end-stage
diseases,
but
a
shortage
of
donors
means
patients
cannot
be
treated.
Xenogeneic
organs
have
become
an
important
part
filling
the
donor
gap.
Many
current
studies
kidney,
heart,
and
liver
xenotransplantation
gene-edited
pig
on
brain-dead
recipients.
However,
endocrine
system,
immune
nervous
system
people
changed,
which
different
from
that
real
transplanted,
research
results
brain
death
(BD)
recipients
also
different.
So
there
drawbacks
using
for
xenotransplantation.
In
addition,
although
policy
requires
use
non-human
primate
(NHP)
experiments
as
standard
xenotransplantation,
still
differences
between
NHP
humans
in
terms
immunity.
Therefore,
better
study
new
models
may
needed
addition
individuals.
Humanized
animal
or
organoids
able
fill
this
Язык: Английский
Advances in cardiac organoid research: implications for cardiovascular disease treatment
Ziteng Huang,
Keran Jia,
Yadan Tan
и другие.
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 18, 2025
Globally,
cardiovascular
diseases
remain
among
the
leading
causes
of
mortality,
highlighting
urgent
need
for
innovative
research
models.
Consequently,
development
accurate
models
that
simulate
cardiac
function
holds
significant
scientific
and
clinical
value
both
disease
therapeutic
interventions.
Cardiac
organoids,
which
are
three-dimensional
structures
derived
from
induced
differentiation
stem
cells,
particularly
promising.
These
organoids
not
only
replicate
autonomous
beating
essential
electrophysiological
properties
heart
but
also
widely
employed
in
studies
related
to
diseases,
drug
efficacy
testing,
regenerative
medicine.
This
review
comprehensively
surveys
various
fabrication
techniques
used
create
their
diverse
applications
modeling
a
range
diseases.
We
emphasize
role
advanced
technologies
enhancing
maturation
functionality
ensuring
these
closely
resemble
native
tissue.
Furthermore,
we
discuss
monitoring
evaluation
parameters
critical
assessing
performance
considering
complex
interactions
within
multi-organ
systems.
approach
is
vital
precision
efficiency
development,
allowing
more
effective
strategies.
Ultimately,
this
aims
provide
thorough
perspective
on
fundamental
treatment
offering
insights
could
pave
way
future
advancements
understanding
addressing
prevalent
health
challenges.
Язык: Английский
Probiotics and Prebiotics: Meeting Dietary Requirements for Optimal Health and Planetary Sustainability
Journal of Nutrition,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Advances in humanoid organoid-based research on inter-organ communications during cardiac organogenesis and cardiovascular diseases
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 28, 2025
The
intimate
correlation
between
cardiovascular
diseases
and
other
organ
pathologies,
such
as
metabolic
kidney
diseases,
underscores
the
intricate
interactions
among
these
organs.
Understanding
inter-organ
communications
is
crucial
for
developing
more
precise
drugs
effective
treatments
systemic
diseases.
While
animal
models
have
traditionally
been
pivotal
in
studying
interactions,
human-induced
pluripotent
stem
cells
(hiPSCs)
offer
distinct
advantages
when
constructing
vitro
models.
Beyond
conventional
two-dimensional
co-culture
model,
hiPSC-derived
humanoid
organoids
emerged
a
substantial
advancement,
capable
of
replicating
essential
structural
functional
attributes
internal
organs
vitro.
This
breakthrough
has
spurred
development
multilineage
organoids,
assembloids,
organoids-on-a-chip
technologies,
which
allow
enhanced
physiological
relevance.
These
technologies
shown
great
potential
mimicking
coordinated
organogenesis,
exploring
disease
pathogenesis,
facilitating
drug
discovery.
As
central
system,
heart
serves
focal
point
an
extensively
studied
network
interactions.
review
focuses
on
advancements
challenges
organs,
presenting
comprehensive
exploration
this
cutting-edge
approach
research.
Язык: Английский
Progress in Disease Modeling for Myocardial Infarction and Coronary Artery Disease: Bridging In Vivo and In Vitro Approaches
Hearts,
Год журнала:
2024,
Номер
5(4), С. 429 - 447
Опубликована: Окт. 4, 2024
Recent
advancements
in
disease
modeling
for
myocardial
infarction
(MI)
and
coronary
artery
(CAD)
have
significantly
enhanced
our
understanding
of
cardiovascular
pathology
therapeutic
development.
This
review
comprehensively
reviews
the
integration
vivo
vitro
approaches
to
better
model
study
these
conditions.
We
specifically
focus
on
cutting-edge
techniques,
such
as
cardiac
organoids,
engineered
heart
tissues,
patient-derived
induced
pluripotent
stem
cells
(iPSCs),
which
allow
detailed
exploration
cellular
molecular
mechanisms
involved
MI
CAD.
These
models
provide
insights
into
ischemic
injury,
remodeling,
effects
potential
interventions
at
a
level.
In
parallel,
we
discuss
advances
models,
including
genetically
modified
mice
large
animal
offer
valuable
information
progression,
function,
response
treatments
within
more
complex
physiological
context.
By
bridging
approaches,
researchers
can
gain
comprehensive
mechanisms,
validate
experimental
findings,
accelerate
development
effective
therapies.
highlights
recent
progress,
identifies
current
limitations,
proposes
strategies
future
research
enhance
translation
model-based
discoveries
clinical
practice
Язык: Английский