Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications
Gels,
Год журнала:
2025,
Номер
11(2), С. 126 - 126
Опубликована: Фев. 9, 2025
Peripheral
nerve
injuries
pose
a
significant
clinical
challenge
due
to
the
complex
biological
processes
involved
in
repair
and
their
limited
regenerative
capacity.
Despite
advances
surgical
techniques,
conventional
treatments,
such
as
autografts,
are
faced
with
limitations
like
donor
site
morbidity
inconsistent
functional
outcomes.
As
such,
there
is
growing
interest
new,
novel,
innovative
strategies
enhance
regeneration.
Tissue
engineering/regenerative
medicine
its
use
of
biomaterials
an
emerging
example
strategy.
Within
realm
tissue
engineering,
functionalized
hydrogels
have
gained
considerable
attention
ability
mimic
extracellular
matrix,
support
cell
growth
differentiation,
even
deliver
bioactive
molecules
that
can
promote
repair.
These
be
engineered
incorporate
factors,
peptides,
stem
cells,
creating
conducive
microenvironment
for
cellular
axonal
Recent
advancements
materials
well
biology
led
development
sophisticated
hydrogel
systems,
not
only
provide
structural
support,
but
also
actively
modulate
inflammation,
recruitment,
stimulate
neurogenesis.
This
review
explores
potential
peripheral
repair,
highlighting
composition,
biofunctionalization,
mechanisms
action.
A
comprehensive
analysis
preclinical
studies
provides
insights
into
efficacy
these
promoting
growth,
neuronal
survival,
regeneration,
and,
ultimately,
recovery.
Thus,
this
aims
illuminate
promise
transformative
tool
field
bridging
gap
between
complexity
feasibility.
Язык: Английский
Advances in hydrogel for diagnosis and treatment for Parkinson’s disease
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 12, 2025
Currently,
few
symptomatic
and
palliative
care
options
are
available
for
patients
with
Parkinson's
disease
(PD).
Interdisciplinary
research
in
materials
engineering
regenerative
medicine
has
stimulated
the
development
of
innovative
therapeutic
strategy
PD.
Hydrogels,
which
versatile
accessible
to
modify,
have
garnered
considerable
interests.
Hydrogels
a
kind
three-dimensional
hydrophilic
network
structure
gels
that
widely
employed
biological
materials.
conspicuous
many
applications,
including
neuron
regeneration,
neuroprotection,
diagnosis.
This
review
focuses
on
advantageous
applications
hydrogel-based
biomaterials
diagnosing
treating
PD,
cell
culture,
modeling,
carriers
cells,
medications
proteins,
as
well
diagnostic
monitoring
biosensors.
Язык: Английский
Gel@CAT-L Hydrogel Mediates Mitochondrial Unfolded Protein Response to Regulate Reactive Oxygen Species and Mitochondrial Homeostasis in Osteoarthritis
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123283 - 123283
Опубликована: Март 1, 2025
Язык: Английский
Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review
Advanced technology in neuroscience .,
Год журнала:
2024,
Номер
1(2), С. 244 - 260
Опубликована: Ноя. 27, 2024
Nerve
injury
often
leads
to
degeneration
or
necrosis
of
damaged
nerve
cells,
which
can
result
in
regeneration
disorders
during
the
repair
process.
Promoting
is
a
critical
challenge
treatment
nervous
system
diseases.
With
rapid
advancements
related
research,
chemical
materials
have
shown
significant
promise
facilitating
because
their
excellent
biocompatibility
and
degradability.
The
use
tissue-engineered
material
scaffolds
provide
physical
channels
for
regeneration.
These
create
optimal
conditions
cell
growth
migration
effectively
regulate
physiological
processes
repair.
Therefore,
wide
range
applications
field
This
review
highlights
technological
tools
available
involving
materials.
(1)
Conductive
hydrogels:
Novel
conductive
hydrogels
been
developed
by
integrating
such
as
graphene,
carbon
nanotubes,
polypyrrole,
promote
functional
recovery
cells
through
electrical
stimulation.
(2)
Three-dimensional
printing:
printing
technology
contributes
precise
control
shape,
porosity
degradation
rate
scaffolds,
providing
customized
microenvironment
(3)
Nanomaterials:
unique
physicochemical
properties
nanoparticles
nanofibers
give
them
great
potential
penetrate
blood‒brain
barrier,
guide
targeted
drug
delivery.
(4)
Local
release
bioactive
molecules:
Through
design
materials,
controlled
molecules
factor,
brain-derived
neurotrophic
factor
fibroblast
has
realized,
promotes
(5)
Photothermal
photoacoustic
stimulation:
combination
photothermal
technologies
led
development
capable
responding
photostimulation,
new
avenues
noninvasive
neurostimulation.
engineering
are
highly
effective
promoting
significantly
improve
efficiency
quality
In
clinical
practice,
these
techniques
expected
more
strategies
patients
with
injuries,
improving
function
life.
also
discusses
detail
different
biocompatibility,
mechanical
strength,
degradability,
A
variety
neural
tissue
scaffold
techniques,
including
provision
support,
molecules,
direct
interaction
cells.
Although
show
potential,
several
challenges,
long-term
stability,
individual
variation
response,
large-scale
production,
still
need
be
addressed
before
they
translated
into
applications.
addition,
comprehensive
assessment
safety
efficacy
focus
future
research.
Future
research
will
on
optimizing
conducting
trials
validate
techniques.
Язык: Английский
Self-assembled Arginine–Glycine–Aspartic Acid Mimic Peptide Hydrogels as Multifunctional Biomaterials for Wound Healing
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 29, 2024
Clinical
management
of
nonhealing
ulcers
requires
advanced
materials
that
can
enhance
wound
closure
rates
without
relying
on
the
release
drugs
or
other
growth
factors
to
obviate
systemic
deleterious
side
effects.
In
our
previous
work,
we
synthesized
an
integrin-binding
cell
adhesive
M
Язык: Английский
Sympathetic chain reconstruction after failed sympathectomy for hyperhidrosis in regenerative medicine: a narrative review
Regenerative medicine reports .,
Год журнала:
2024,
Номер
1(2), С. 149 - 155
Опубликована: Дек. 1, 2024
Hyperhidrosis
is
a
pathologic
condition
characterized
by
abnormal
sweating
that
greater
than
normally
needed
for
proper
thermoregulation.
Surgical
therapy
remains
the
only
effective
treatment
definitive
cure
of
idiopathic
focal
hyperhidrosis,
although
some
controversies
still
exist
regarding
best
operation.
The
most
significant
side
effect
hyperhidrosis
surgery
compensatory
hyperhidrosis.
Although
severe
less
frequent
form,
it
results
in
detrimental
on
quality
life,
and
restoration
pre-surgical
advocated
affected
patients.
Sympathetic
chain
reconstruction
represents
surgical
option
managing
after
failed
sympathetic
surgery,
without
results.
In
this
review,
we
focus
experimental
clinical
data
use
compensated
sympathectomy
Regenerative
medicine,
particularly
tissue
engineering
stem
cell
technology,
offers
new
therapeutic
strategies
reconstruction.
These
may
improve
or
resolve
promoting
nerve
regeneration.
However,
there
are
number
problems
with
current
research,
including
inconsistency
outcomes,
lack
long-term
follow-up
data,
insufficient
in-depth
understanding
regenerative
medicine
techniques.
Nonetheless,
progress
has
been
made
studies.
For
example,
regeneration
demonstrated
animal
models,
different
methods
reconstruction,
autologous
grafts
conduits,
have
shown
studies
provide
preliminary
evidence
significance
conclusion,
development
hope
patients
primary
even
though
treatments
not
yet
achieved
desired
With
further
technological
technology
expected
to
be
means
treating
thus
significantly
improving
life
Язык: Английский