Multifunctional hydrogel scaffolds based on polysaccharides and polymer matrices promote bone repair: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
294, С. 139418 - 139418
Опубликована: Янв. 5, 2025
Язык: Английский
Advances in three-dimensional printing of hydrogel formulations for vascularized tissue and organ regeneration
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2025,
Номер
unknown, С. 1 - 43
Опубликована: Фев. 3, 2025
Over
the
last
decades,
three-dimensional
(3D)
printing
has
emerged
as
one
of
most
promising
alternative
tissue
and
organ
regeneration
technologies.
Recent
advances
in
3D
technology,
particularly
hydrogel-derived
bioink
formulations,
offer
solutions
for
fabricating
intricate,
biomimetic
scaffolds
that
promote
vascularization.
In
this
review,
we
presented
numerous
studies
have
been
conducted
to
fabricate
3D-printed
hydrogel
vascularized
constructs
with
significant
advancements
integumentary
systems,
cardiovascular
bone
tissues,
skeletal
muscles,
livers,
kidneys.
Furthermore,
work
also
discusses
engineering
considerations,
current
challenges,
proposed
solutions,
future
outlooks
bioprinting.
Язык: Английский
In situ 3D bioprinted GDMA/Prussian blue nanozyme hydrogel with wet adhesion promotes macrophage phenotype modulation and intestinal defect repair
Su Yang,
Jingyi Ju,
Chengyin Shen
и другие.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101636 - 101636
Опубликована: Март 5, 2025
Developing
hydrogels
with
wet-adhesion,
immunomodulation
and
regenerative
repair
capabilities
in
intestinal
remains
a
formidable
challenge.
In
the
present
study,
development
of
an
anti-inflammatory,
wet-adhesive,
decellularized
extracellular
matrix
hydrogel
produced
using
three-dimensional
(3D)
-printing
technology
is
presented.
This
hydrogel,
which
integrates
gelatin
dopamine,
was
demonstrated
to
display
excellent
wet-adhesion
properties,
fully
harnessing
outstanding
potential
small-intestine
matrix.
Furthermore,
integration
Prussian
Blue
nanozymes
imparted
significant
anti-inflammatory
antioxidant
properties.
Through
modulating
macrophage
polarization,
not
only
found
enhance
tissue
repair,
but
also
substantially
mitigate
inflammation.
vivo
experiments
(namely,
histopathological
analyses
rat
model)
that
this
able
effectively
regeneration
healing
models
damage.
conclusion,
through
utilization
3D-printing
technology,
study
has
shown
precise
manufacturing
customization
various
shapes
sizes
defects
may
be
executed,
thereby
providing
innovative
strategy
for
repair.
advanced
therefore
been
hold
promise
as
bioadhesive
both
emergency
therapy.
Язык: Английский
Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release
ACS Omega,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Hydrogels
are
highly
versatile
materials
with
immense
potential
for
tissue
engineering
and
regenerative
medicine
owing
to
their
biocompatibility,
tunable
mechanical
properties,
ability
mimic
the
natural
extracellular
matrix.
Their
3D
porous
structure
allows
encapsulation
delivery
of
bioactive
molecules,
making
them
ideal
candidates
drug
systems.
In
repair,
particularly
bone
regeneration,
hydrogels
can
serve
as
carriers
that
release
therapeutic
agents
in
a
controlled
manner,
thus
enhancing
healing
process.
Zeolitic
Imidazolate
Framework-8
(ZIF-8)
nanoparticles
recombinant
human
Bone
Morphogenetic
Protein
(rhBMP-2)
molecules
were
incorporated
solely
(ZIF@GelMA)
or
association
(BMP@ZIF@GelMA)
into
gelatin
modified
by
methacryloyl
hydrogel
(GelMA)
investigate
its
physical
osteogenic
properties.
characterized
Scanning
Electron
Microscopy
rheological
tests.
We
analyzed
degradation
BSA
profile
BMP@ZIF@GelMA
samples
throughout
0,
1,
3,
7,
14,
28
days.
Cell
adhesion
formation
markers
hydrogel-encapsulated
dental
pulp
cells
using
immunocytochemistry
molecular
analysis.
ZIF@GelMA
exhibited
viscoelastic
increased
storage
modulus
when
rhBMP2
was
present.
BSA@ZIF@GelMA
showed
balanced
rate
BSA.
The
upregulated
expression
cell
genes,
BMP-2
introduced,
levels
remarkably
elevated.
presents
several
favorable
factors
promote
cellular
encouraging
further
prospects
advanced
applications
repair.
Язык: Английский
Metal-Free Antioxidant Nanozyme Incorporating Bioactive Hydrogel as an Antioxidant Scaffold for Accelerating Bone Reconstruction
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123285 - 123285
Опубликована: Март 1, 2025
Язык: Английский
Immuno-Osteoinductive 3D Printed Hydrogel Scaffolds with Triple Crosslinking and GA/EGCG Release for Bone Healing
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
unknown, С. 114651 - 114651
Опубликована: Март 1, 2025
Язык: Английский
Metal coordination-based double-network microsphere scaffolds facilitate bone regeneration via oxygen-driven mitochondrial oxidative phosphorylation
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 162233 - 162233
Опубликована: Апрель 1, 2025
Язык: Английский
Hierarchical engineering scaffolds for oral and craniofacial tissue regeneration: Recent advances and challenges
Jingyi Gu,
Zhiwei Ke,
Hui Pan
и другие.
Applied Materials Today,
Год журнала:
2024,
Номер
42, С. 102546 - 102546
Опубликована: Дек. 19, 2024
Язык: Английский
Polyphenols and Functionalized Hydrogels for Osteoporotic Bone Regeneration
Dejia Xv,
Yuming Cao,
Yue Hou
и другие.
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Abstract
Osteoporosis
induces
severe
oxidative
stress
and
disrupts
bone
metabolism,
complicating
the
treatment
of
defects.
Current
therapies
often
have
side
effects
require
lengthy
regeneration
periods.
Hydrogels,
known
for
their
flexible
mechanical
properties
degradability,
are
promising
carriers
drugs
bioactive
factors
in
tissue
engineering.
However,
they
lack
ability
to
regulate
local
pathological
environment
osteoporosis
expedite
repair.
Polyphenols,
with
antioxidative,
anti‐inflammatory,
metabolism‐regulating
properties,
emerged
as
a
solution.
Combining
hydrogels
polyphenols,
polyphenol‐based
can
metabolism
while
providing
support
adhesion,
promoting
osteoporotic
regeneration.
This
review
first
provides
brief
overview
types
polyphenols
mechanisms
facilitating
antioxidant,
modulation
modulating
osteoporosis.
Next,
this
examines
recent
advances
defects,
including
use
angiogenesis,
modulation,
drug
delivery,
stem
cell
therapy.
Finally,
it
highlights
latest
research
on
polyphenol
defect
Overall,
aims
facilitate
clinical
application
Язык: Английский