Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration

BioMedical Engineering OnLine, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 7, 2025

Articular cartilage injury is a serious bone disease that can result in disabilities. With the rapid increase aging population, this disorder has become an increasingly important public health issue. Recently, stem cell-based tissue engineering emerged as promising therapeutic option for treating articular damage. Cellular scaffolds, which are among three key elements of engineering, play significant roles repair damaged by regulating cellular responses and promoting regeneration. Biological macromolecules commonly used scaffold materials owing to their unique properties. For example, natural synthetic polymer hydrogel scaffolds effectively mimic microenvironment extracellular matrix; exhibit high cytocompatibility, biocompatibility, biodegradability; have attracted increasing attention regeneration medicine. Several types been fabricated treat abnormalities. This article outlines recent progress field manufactured from various biomaterials repairing cartilage, discusses advantages disadvantages, proposes directions future development.

Язык: Английский

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Exosome-Loaded Tannic Acid–Thioctic Acid Hydrogel Enhances Wound Healing in Coagulation Disorders

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101496 - 101496

Опубликована: Янв. 25, 2025

Язык: Английский

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Benign separated cellulose adhesive hydrogel via constructing double dynamic covalent bonds for ultra-fast hemostasis and antibacterial

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160665 - 160665

Опубликована: Фев. 1, 2025

Язык: Английский

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Controlled-Release of Cinnamaldehyde from MXene/ZIF8/Gelatin Composite Coatings: An Integrated Strategy to Combat Implant-Associated Infection

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 251, С. 114615 - 114615

Опубликована: Март 7, 2025

Язык: Английский

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Exosomes as Biomarkers and Therapeutic Agents in Neurodegenerative Diseases: Current Insights and Future Directions

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Neurodegenerative diseases (NDs) like Alzheimer’s, Parkinson’s, and ALS rank among the most challenging global health issues, marked by substantial obstacles in early diagnosis effective treatment. Current diagnostic techniques frequently demonstrate inadequate sensitivity specificity, whilst conventional treatment strategies encounter challenges related to restricted bioavailability insufficient blood–brain barrier (BBB) permeability. Recently, exosomes—nanoscale vesicles packed with proteins, RNAs, lipids—have emerged as promising agents potential reshape therapeutic approaches these diseases. Unlike drug carriers, they naturally traverse BBB can deliver bioactive molecules affected neural cells. Their molecular cargo influence cell signaling, reduce neuroinflammation, potentially slow neurodegenerative progression. Moreover, exosomes serve non-invasive biomarkers, enabling precise while allowing real-time disease monitoring. Additionally, engineered exosomes, loaded molecules, enhance this capability targeting diseased neurons overcoming barriers. By offering enhanced reduced immunogenicity, an ability bypass physiological limitations, exosome-based present a transformative advantage over existing approaches. This review examines multifaceted role of NDDs, emphasizing their capabilities, intrinsic functions, advanced vehicles.

Язык: Английский

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Accelerated healing of full-thickness skin wounds by multifunctional exosome-loaded scaffolds of alginate hydrogel/PCL nanofibers with hemostatic efficacy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142271 - 142271

Опубликована: Март 1, 2025

Язык: Английский

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Enhanced therapeutic effects of ginseng-derived exosome-like nanoparticles loaded hyaluronic acid injectable hydrogels for breast tumor treatment

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 142914 - 142914

Опубликована: Апрель 25, 2025

Язык: Английский

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