Remodeling Tumor Microenvironment Using Prodrug nMOFs for Synergistic Cancer Therapy DOI Creative Commons
Jun-Liang Dong,

Jin-Dong Ding,

Shuang Luo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Abstract Metal-organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (DCCMH) using metformin (Met) α-cyano-4-hydroxycinnamic acid (CHCA) ligands coordination self-assembly with Cu2+, followed by loading of DOX surface modification HA. Upon internalization cells, DCCMH releases CHCA, Met, response high levels GSH-H2O2 within the tumor microenvironment (TME); Cu2+ depletes GSH generates Cu+ that subsequently catalyzes H2O2 hydroxyl radical through Fenton reaction; CHCA induces further decrease intracellular pH promotes reactions inhibiting lactate efflux; Met up-regulates tyrosine kinase activity enhances chemotherapy DOX. With abilities synergistically combine chemo/chemodynamic remodel TME, nMOFs inhibit murine hepatoma effectively. This study presents feasible strategy fabricating which capable remodeling TME improve efficacy synergistic therapy.

Язык: Английский

Advances in Synthetic Immunology for Targeted Treatment of Systemic Autoimmune Diseases: Opportunities, Challenges, and Future Directions DOI Creative Commons

Galih Januar Adytia,

Henry Sutanto,

Laras Pratiwi

и другие.

Immuno, Год журнала: 2025, Номер 5(1), С. 6 - 6

Опубликована: Янв. 25, 2025

Systemic autoimmune diseases (SAIDs) affect millions worldwide, presenting significant clinical challenges due to their complex pathogenesis and limited treatment options. Traditional immunosuppressive therapies, while effective, often lack precision, leading side effects inadequate disease control. Recent advances in synthetic immunology offer promising avenues for precise, targeted interventions SAIDs. This review examines the latest innovations treating diseases, focusing on engineered immune cells, biologics, gene-editing technologies. It explores therapeutic potential of these approaches modulate tolerance, reduce systemic inflammation, enhance patient-specific efficacy. However, despite developments, remain, including system complexity, safety concerns, regulatory hurdles that may hinder translation. aims consolidate current advancements, address existing barriers, outline future directions management, highlighting immunology’s role transforming landscape

Язык: Английский

Процитировано

2
Cell-free DNA-scavenging nano/microsystems for immunotherapy DOI
Wenhan Zhao, Yang Zhou, Lichen Yin

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113609 - 113609

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Nano-Delivery of STING Agonists: Unraveling the Potential of Immunotherapy DOI
Meng Zhang,

Yating Ji,

Mingxia Liu

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Emerging dendrimer-based RNA delivery strategies DOI

Sneha Das,

Bhavesha Chanchlani,

P S Shishira

и другие.

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Апрель 3, 2025

Dendrimers represent a class of polymers characterized by highly branched architecture, precise composition, and multitude functional groups, garnering significant interest in biomedical applications. These are three-dimensional nanostructures high degree molecular homogeneity, adjustable size, multivalence, surface functionality, aqueous solubility.Dendrimers, owing to their properties, currently utilized for drug delivery under investigation as potential carriers nucleic acid-based vaccines. Nucleic acid, therapeutic molecule, offers several advantages, including safety, efficacy, cost-effectiveness. systems may exhibit accelerated development timelines, reduced production costs, enhanced storage transportation efficiency. An essential aspect DNA or RNA technology is the selection an efficient method delivery.This review summarizes classification, preparation, formulation strategies dendrimer delivery. Furthermore, via dendrimers range disease conditions, cancer, autoimmune disorders, infectious diseases, neurological metabolic has been investigated summarized.

Язык: Английский

Процитировано

0
Remodeling Tumor Microenvironment Using Prodrug nMOFs for Synergistic Cancer Therapy DOI Creative Commons
Jun-Liang Dong,

Jin-Dong Ding,

Shuang Luo

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Abstract Metal-organic frameworks (MOFs) hold tremendous potential in cancer therapy due to their remarkable structural and functional adaptability, enabling them serve as nanocarriers for biopharmaceuticals nanoreactors organizing cascade bioreactions. Nevertheless, MOFs are predominantly utilized biologically inactive carriers most cases. Developing nanoscale prodrug suitable biomedical applications remains a huge challenge. In this study, we have designed novel nano-MOFs (DCCMH) using metformin (Met) α-cyano-4-hydroxycinnamic acid (CHCA) ligands coordination self-assembly with Cu2+, followed by loading of DOX surface modification HA. Upon internalization cells, DCCMH releases CHCA, Met, response high levels GSH-H2O2 within the tumor microenvironment (TME); Cu2+ depletes GSH generates Cu+ that subsequently catalyzes H2O2 hydroxyl radical through Fenton reaction; CHCA induces further decrease intracellular pH promotes reactions inhibiting lactate efflux; Met up-regulates tyrosine kinase activity enhances chemotherapy DOX. With abilities synergistically combine chemo/chemodynamic remodel TME, nMOFs inhibit murine hepatoma effectively. This study presents feasible strategy fabricating which capable remodeling TME improve efficacy synergistic therapy.

Язык: Английский

Процитировано

0