International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138337 - 138337
Опубликована: Дек. 5, 2024
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Язык: Английский
Процитировано
1
Biomaterials, Год журнала: 2025, Номер 319, С. 123212 - 123212
Опубликована: Фев. 24, 2025
Язык: Английский
Процитировано
1
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 13, 2024
As novel multifunctional materials that merge enzyme-like capabilities with the distinctive traits of nanomaterials, nanozymes have made significant strides in interdisciplinary research areas spanning science, bioscience, and beyond. This article, for first time, employed bibliometric methods to conduct an in-depth statistical analysis global demonstrate progress, hotspots trends. Drawing on data from Web Science Core Collection database, we comprehensively retrieved publications 2004 2024. The burgeoning interest across various nations indicated a growing widespread trend. article further systematically elaborated activities, matrix, properties, catalytic mechanisms applications nanozymes, field encounters challenges. Despite notable requires deeper exploration guide future directions. harbors broad potential developments, promising impact aspects technology society.
Язык: Английский
Процитировано
6
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Abstract Bacterial infections can lead to severe medical complications, including major incidents and even death, posing a significant challenge in clinical trauma repair. Consequently, the development of new, efficient, non‐resistant antimicrobial agents has become priority for practitioners. In this study, stepwise hydrothermal reaction strategy is utilized prepare Fe 3 O 4 @MoS 2 core–shell nanoparticles (NPs) with photosynthesis‐like activity treatment bacterial infections. The NPs continuously catalyze production reactive oxygen species (ROS) from hydrogen peroxide through reactions convert light energy into heat photothermal efficiency 30.30%. addition, photosynthetically generated ROS, combined iron‐induced cell death mechanism NPs, confer them exceptional broad‐spectrum antibacterial properties, achieving activities up 98.62% Staphylococcus aureus , 99.22% Escherichia coli 98.55% methicillin‐resistant . composite exhibits good safety hemocompatibility. Finally, full‐thickness diabetic wound model validates pro‐healing properties chronic wounds. Overall, design photosynthesis‐inspired presents new perspectives developing efficient nano‐enzymatic compounds, offering promising solution challenges drug resistance antibiotic misuse.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
20% acute pancreatitis (AP) develops into severe AP (SAP), a global health crisis, with an increased mortality rate to 30%–50%. Mitochondrial damage and immune disorders are direct factors, which exacerbate the occurrence progression of AP. So far, mitochondrial immunity injury in SAP remains largely elusive, no established treatment options available. Immunomodulation is promising approach treat pancreatitis. Herein, we proved that Tuftsin (TN), vital endogenous immunomodulator, can inhibit SAP, while it limited by extremely short biological half-life, low bioavailability, inconvenience administration. Nano platform positive choice. Interestingly, found activated P2X7 signaling was closely associated enhanced pancreatic inflammation via damaging function SAP. engineered nanoplatform containing Se–Se bond responsive for ROS deliver TN, namely, DSPE–Se-Se-MPEG@TN (DSSM@TN), contributing increases TN's half-life bioavailability. We synthesized TN-loaded ROS-responsive DSPE–Se-Se- MPEG@TN liposomes (DSSM@TN NPs) one-step emulsification method, exhibited good biosecurity, high stability, suitable size, favorable responsiveness biocompatibility, as well excellent capability releasing TN during oxidative stress environment. Moreover, ability first play role enhance its anti-inflammation antioxidant abilities targeting damaged mitochondria progression. Mechanistically, DSSM@TN pancreas simultaneously inhibits dysfunction vivo vitro signaling-impaired Nrf2/HO-1 signaling-inhibited PINK1/PARKIN pathway. Consequently, such immunotherapy nanomedicine targeted holds great potential facilitating substantial clinical progress treatment.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Serine hydrolases, as a class of green catalysts with hydrolytic and dehydrating activities, hold significant application value in the fields biosynthesis organic synthesis. However, practical applications face numerous challenges, including maintaining enzyme stability managing usage costs. PepNzymes-SH, an emerging catalytic material enzyme-like activity, overcomes operational limitations natural enzymes holds great promise substitute for hydrolases. Unfortunately, systematic review design strategies PepNzymes-SH is currently lacking. The core significance this report lies providing researchers comprehensive understanding theoretical guidance through summarization performance evaluation different PepNzymes-SH. This summarizes simulating enhancing serine hydrolase active sites, oxyanion holes, hydrophobic environmental structures. By comparing their we assess changes brought about by strategies. Furthermore, chemical, biomedicine, are also discussed.
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2043 - 2057
Опубликована: Фев. 1, 2025
Natural enzyme systems possess extraordinary functions and characteristics, making them highly appealing for use in eco-friendly technologies innovative cancer treatments. However, their inherent instability structural complexity often limit practical applications, leading to the exploration of biomolecular nanozyme alternatives. Supramolecular nanozymes, constructed using self-assembly techniques various non-covalent interactions, have emerged as a promising solution. Amino acids, peptides, protein motifs offer flexible building blocks constructing these nanozymes. Importantly, well-defined regulation mechanisms along with unique properties fundamental biological modules living systems-such selectivity, permeability, retention, biocompatibility-present new opportunities therapy. This review highlights recent advances supramolecular self-assembled including peroxidases, oxidases, catalases, superoxide dismutases, other systems, tumor Additionally, it discusses precise functional modulation through interactions therapeutic applications targeting microenvironment. These studies provide valuable insights that may inspire design novel nanozymes enhanced catalytic biocompatibility, tumor-killing efficacy.
Язык: Английский
Процитировано
0
Talanta, Год журнала: 2025, Номер unknown, С. 127957 - 127957
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3522 - 3522
Опубликована: Апрель 9, 2025
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), amyotrophic lateral (ALS) and Huntington’s (HD), represent a significant challenge to global health due their progressive nature the absence of curative treatments. These disorders are characterized by oxidative stress, protein misfolding, neuroinflammation, which collectively contribute neuronal damage death. Recent advancements in nanotechnology have introduced nanozymes—engineered nanomaterials that mimic enzyme-like activities—as promising therapeutic agents. This review explores multifaceted roles nanozymes combating stress inflammation neurodegenerative conditions. By harnessing potent antioxidant properties, can effectively scavenge reactive oxygen species (ROS) restore redox balance, thereby protecting function. Their ability modify surface properties enhances targeted delivery biocompatibility, making them suitable for various biomedical applications. In this review, we highlight recent findings on design, functionality, potential nanozymes, emphasizing dual role addressing pathological features such as aggregation. synthesis current research underscores innovative proactive strategy halt progression improve patient outcomes disorders.
Язык: Английский
Процитировано
0
Chemistry of Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
Язык: Английский
Процитировано
0