Advances in locally administered nucleic acid therapeutics DOI
Jie Shen, Xiangfeng Duan, Ting Xie

и другие.

Bioactive Materials, Год журнала: 2025, Номер 49, С. 218 - 254

Опубликована: Март 10, 2025

Язык: Английский

Recent advances in self-targeting natural product-based nanomedicines DOI Creative Commons

Haifan Liu,

Xingyue Jin, Suyi Liu

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

3
Hexahistidine-metal assembly encapsulated fibroblast growth factor 21 for lipopolysaccharide-induced acute lung injury DOI

Lanlan Song,

Huihui Ye,

Zhanghang Lv

и другие.

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2025, Номер unknown, С. 114650 - 114650

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Exploring the anti-inflammatory effects of Radix Curcumae essential oil in pulmonary sarcoidosis via the TLR4/MyD88/NF-κB pathway DOI
Zhiguo Mao,

Xia Lin,

Yilong Hu

и другие.

Phytomedicine, Год журнала: 2025, Номер 139, С. 156496 - 156496

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
Effects of Surface Charge of Inhaled Liposomes on Drug Efficacy and Biocompatibility DOI Creative Commons

Jinniu Zhang,

Yun Huang,

Wenhao Shen

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 329 - 329

Опубликована: Март 3, 2025

Objectives: Liposomes are a promising drug carrier for inhaled delivery systems and their physical parameters could influence therapeutic efficacy significantly. This study was designed to answer the specific question of proper surface charge liposomes in pulmonary inhalation, as well synergistic anti-inflammation between drugs. Methods: In this work, series drug-loaded with different charges (from negative positive) were prepared, several vitro vivo assays, including cytotoxicity, hemolysis assay, mucus penetration lipopolysaccharide (LPS)-induced pneumonia model test, adopted evaluate biocompatibility above liposomes. Results: Compared cationic liposomes, anionic capable better good (low blood compatibility mild tissue inflammation), but poor cellular uptake by immune cells. specific, even when liposome only +2.6 mV, its cytotoxicity reached around 20% 15%, respectively. Furthermore, there no significant difference (−25.9 vs. −2.5 mV), slightly negative-charged exhibited uptake. Conclusions: Thus, (−1~−3 mV) be considering both biocompatibility. an LPS-induced mouse model, achieved anti-inflammatory compared free

Язык: Английский

Процитировано

0
Advances in locally administered nucleic acid therapeutics DOI
Jie Shen, Xiangfeng Duan, Ting Xie

и другие.

Bioactive Materials, Год журнала: 2025, Номер 49, С. 218 - 254

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0