Cellulose-mediated mechanical property tuning in small intestinal submucosal matrix to enhance stem cell osteogenic differentiation

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 295, С. 139575 - 139575

Опубликована: Янв. 8, 2025

Язык: Английский

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Current Status and Perspectives of Research on Polymer Hydrogels in the Treatment and Protection of Osteoarthritis

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Abstract Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions people worldwide and often has serious consequences such as joint pain swelling, limited mobility, deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective for arthritis remains an important clinical challenge. As hydrogels have unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, good biodegradability, they can provide suitable cellular or tissue microenvironment, their potential in scaffolding effect, lubrication, anti‐inflammatory drug delivery expected be potent therapeutic approach the treatment osteoarthritis. In this review, three aspects hydrogel products osteoarthritis are comprehensively summarized discussed, namely, selection gel design, exploration cross‐linking mechanisms, mechanisms therapy osteoarthritis, focus on advantages limitations applications, which point out direction development strategy innovative field, applied research, transformation.

Язык: Английский

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Construction of hydrogels with specific structures and functions for cartilage defects and traumatic osteoarthritis: A review

Chemical Engineering Journal, Год журнала: 2024, Номер 503, С. 158242 - 158242

Опубликована: Дек. 3, 2024

Язык: Английский

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3D bio-printed proteinaceous bioactive scaffold loaded with dual growth factor enhanced chondrogenesis and in situ cartilage regeneration

Bioactive Materials, Год журнала: 2024, Номер 46, С. 365 - 385

Опубликована: Дек. 31, 2024

Язык: Английский

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