Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Gelu Onose

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 344 - 344

Опубликована: Фев. 27, 2025

Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells endothelial are particularly susceptible damage, which exacerbates aging through cellular senescence, chronic inflammation, arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by H2S, NO, CO influence smooth cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, activates antioxidant pathways. NO improves function, promotes vasodilation, inhibits platelet aggregation. exhibits cytoprotective anti-inflammatory effects modulating heme oxygenase activity ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) targeted show significant promise. Synergistic with lifestyle modifications further enhance their potential. conclusion, gasotransmitters hold promise combat age-related cells. Their multifaceted innovative approaches make them potential candidates treating dysfunction promoting healthy aging. Further research needed translate into clinical applications.

Язык: Английский

Harnessing Gasotransmitters to Combat Age-Related Oxidative Stress in Smooth Muscle and Endothelial Cells DOI Creative Commons
Constantin Munteanu, Anca‐Irina Galaction, Gelu Onose

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 344 - 344

Опубликована: Фев. 27, 2025

Age-related oxidative stress is a critical factor in vascular dysfunction, contributing to hypertension and atherosclerosis. Smooth muscle cells endothelial are particularly susceptible damage, which exacerbates aging through cellular senescence, chronic inflammation, arterial stiffness. Gasotransmitters—hydrogen sulfide (H2S), nitric oxide (NO), carbon monoxide (CO)—are emerging as promising therapeutic agents for counteracting these processes. This review synthesizes findings from recent studies focusing on the mechanisms by H2S, NO, CO influence smooth cell function. Therapeutic strategies involving exogenous gasotransmitter delivery systems combination therapies were analyzed. H2S enhances mitochondrial bioenergetics, scavenges ROS, activates antioxidant pathways. NO improves function, promotes vasodilation, inhibits platelet aggregation. exhibits cytoprotective anti-inflammatory effects modulating heme oxygenase activity ROS production. In preclinical studies, gasotransmitter-releasing molecules (e.g., NaHS, SNAP, CORMs) targeted show significant promise. Synergistic with lifestyle modifications further enhance their potential. conclusion, gasotransmitters hold promise combat age-related cells. Their multifaceted innovative approaches make them potential candidates treating dysfunction promoting healthy aging. Further research needed translate into clinical applications.

Язык: Английский

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