Challenges and Opportunities: Nanomaterials in Epilepsy Diagnosis DOI

Wanbin Huang,

Jiabin Zong,

Ming Li

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Epilepsy is a common neurological disorder characterized by significant rate of disability. Accurate early diagnosis and precise localization the epileptogenic zone are essential for timely intervention, seizure prevention, personalized treatment. However, over 30% patients with epilepsy exhibit negative results on electroencephalography magnetic resonance imaging (MRI), which can lead to misdiagnosis subsequent delays in Consequently, enhancing diagnostic methodologies imperative effective management. The integration nanomaterials biomedicine has led development tools epilepsy. Key advancements include nanomaterial-enhanced neural electrodes, contrast agents, biochemical sensors. Nanomaterials improve quality electrophysiological signals broaden detection range electrodes. In imaging, functionalized nanoparticles enhance MRI sensitivity, facilitating zone. NIR-II nanoprobes enable tracking seizure-related biomarkers deep tissue penetration. Furthermore, sensitivity sensors detecting biomarkers, crucial detection. These significantly increase specificity. challenges remain, particularly regarding biosafety, control, scalability fabrication processes. Overcoming these obstacles successful clinical translation. Artificial-intelligence-based big data analytics facilitate screening specific properties. This approach may help address current limitations both effectiveness safety. review explores application epilepsy, objective inspiring innovative ideas strategies effectiveness.

Язык: Английский

Challenges and Opportunities: Nanomaterials in Epilepsy Diagnosis DOI

Wanbin Huang,

Jiabin Zong,

Ming Li

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Epilepsy is a common neurological disorder characterized by significant rate of disability. Accurate early diagnosis and precise localization the epileptogenic zone are essential for timely intervention, seizure prevention, personalized treatment. However, over 30% patients with epilepsy exhibit negative results on electroencephalography magnetic resonance imaging (MRI), which can lead to misdiagnosis subsequent delays in Consequently, enhancing diagnostic methodologies imperative effective management. The integration nanomaterials biomedicine has led development tools epilepsy. Key advancements include nanomaterial-enhanced neural electrodes, contrast agents, biochemical sensors. Nanomaterials improve quality electrophysiological signals broaden detection range electrodes. In imaging, functionalized nanoparticles enhance MRI sensitivity, facilitating zone. NIR-II nanoprobes enable tracking seizure-related biomarkers deep tissue penetration. Furthermore, sensitivity sensors detecting biomarkers, crucial detection. These significantly increase specificity. challenges remain, particularly regarding biosafety, control, scalability fabrication processes. Overcoming these obstacles successful clinical translation. Artificial-intelligence-based big data analytics facilitate screening specific properties. This approach may help address current limitations both effectiveness safety. review explores application epilepsy, objective inspiring innovative ideas strategies effectiveness.

Язык: Английский

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