Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(1), С. 8 - 8
Опубликована: Март 7, 2025
Photodynamic
and
photothermal
therapies
with
IR780
have
gained
exponential
interest,
their
photophysical
properties
demonstrated
promise
for
use
in
antitumor
antimicrobial
chemotherapy.
its
derivatives
are
valuable
labeling
nanostructures
different
chemical
compositions
vitro
vivo
fluorescence
monitoring
studies
the
near-infrared
(NIR)
spectrum.
The
current
literature
is
abundant
on
this
topic,
particularly
applications
treatment
of
types
cancer
using
laser
illumination
to
produce
photodynamic
(PDT),
(PTT),
and,
more
recently,
sonodynamic
therapy
(SDT)
approaches
cell
death.
This
review
aims
update
state
art
concerning
photosensitizer
as
a
theranostic
agent
PDT,
PTT,
SDT,
photoacoustic
(PA)
effects,
imaging
associated
nanocarriers.
concerns
period
from
2017
2024,
considering,
specifically,
effects
found
preclinical
experiments.
Some
aspects
stability
nanostructured
systems
will
be
discussed
based
evidence
leakage
nanocarrier
consequences
reliable
analysis
biological
data.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
165, С. 115070 - 115070
Опубликована: Июнь 28, 2023
At
present,
cancer
remains
one
of
the
leading
causes
human
death
worldwide,
and
surgery,
radiotherapy
chemotherapy
are
still
main
methods
treatment.
However,
these
treatments
have
their
drawbacks.
Surgical
treatment
often
struggles
with
complete
removal
tumor
tissue,
to
a
high
risk
recurrence.
Additionally,
drugs
significant
impact
on
overall
health
can
easily
result
in
drug
resistance.
The
mortality
other
reasons
promote
scientific
researchers
unremittingly
develop
find
more
accurate
faster
diagnosis
strategy
effective
method.
Photothermal
therapy,
which
utilizes
near-infrared
light,
offers
deeper
tissue
penetration
minimal
damage
surrounding
healthy
tissues.
Compared
conventional
methods,
photothermal
therapy
boasts
several
advantages,
including
efficiency,
non-invasiveness,
simplicity,
toxicity,
fewer
side
effects.
nanomaterials
be
categorized
as
either
organic
or
inorganic
materials.
This
review
primarily
focuses
behavior
carbon
materials
role
Furthermore,
challenges
faced
by
discussed.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(11), С. 13543 - 13562
Опубликована: Март 7, 2024
We
use
low-molecular-weight
branched
polyethylenimine
(PEI)
to
produce
cytocompatible
reduced
graphene
oxide
quantum
dots
(rGOQD)
as
a
photothermal
agent
and
covalently
bind
it
with
the
photosensitizer
IR-820.
The
rGOQD/IR820
shows
high
conversion
efficiency
produces
reactive
oxygen
species
(ROS)
after
irradiation
near-infrared
(NIR)
light
for
photothermal/photodynamic
therapy
(PTT/PDT).
To
improve
suspension
stability,
was
PEGylated
by
anchoring
DSPE
hydrophobic
tails
in
DSPE-PEG-Mal,
leaving
maleimide
(Mal)
end
group
covalent
binding
manganese
dioxide/bovine
serum
albumin
(MnO2/BSA)
targeting
ligand
cell-penetrating
peptide
(CPP)
synthesize
rGOQD/IR820/MnO2/CPP.
As
MnO2
can
react
intracellular
hydrogen
peroxide
alleviating
hypoxia
condition
acidic
tumor
microenvironment,
efficacy
of
PDT
could
be
enhanced
generating
more
cytotoxic
ROS
NIR
light.
Furthermore,
quercetin
(Q)
loaded
rGOQD
through
π–π
interaction,
which
released
endosomes
act
an
inhibitor
heat
shock
protein
70
(HSP70).
This
sensitizes
cells
thermal
stress
increases
mild-temperature
PTT
irradiation.
By
simultaneously
incorporating
HSP70
situ
(MnO2),
rGOQD/IR820/MnO2/Q/CPP
overcome
limitation
PTT/PDT
enhance
targeted
phototherapy
vitro.
From
vivo
study
orthotopic
brain
model,
administered
tail
vein
injection
cross
blood–brain
barrier
accumulate
intracranial
tumor,
laser
shrink
prolong
survival
times
animals
enhancing
treat
glioblastoma.
Pharmaceutics,
Год журнала:
2023,
Номер
15(1), С. 290 - 290
Опубликована: Янв. 14, 2023
Combination
chemo-photothermal
therapy
with
nanomaterials
can
reduce
the
dose
of
chemotherapeutic
drugs
required
for
effective
cancer
treatment
by
minimizing
toxic
side
effects
while
improving
survival
times.
Toward
this
end,
we
prepare
hyaluronic
acid
(HA)-modified
poly(lactic-co-glycolic
acid)
(PLGA)
magnetic
nanoparticles
(MNP)
CD44
receptor-mediated
and
field-guided
dual-targeted
delivery
cisplatin
(CDDP).
By
co-encapsulating
CDDP
oleic
acid-coated
iron
oxide
MNP
(IOMNP)
in
PLGA,
PMNPc
was
first
prepared
a
single
emulsification/solvent
evaporation
step
successively
surface
modified
chitosan
HA
to
HA/PMNPc.
Spherical
HA/PMNPc
~300
nm
diameter
be
18
10%
(w/w)
loading
content
IOMNP
pH-sensitive
drug
release
facilitate
endosomal
after
intracellular
uptake.
This
leads
higher
cytotoxicity
toward
U87
glioblastoma
cells
than
free
reduced
IC50,
cell
apoptosis
rate,
enhanced
expression
marker
proteins.
Furthermore,
show
hyperthermia
effect
short-term
near-infrared
(NIR)
light
exposure,
which
further
elevate
apoptosis/necrosis
rate
upregulate
HSP70
protein
due
photothermal
effects.
The
combined
therapeutic
efficacy
studied
vivo
using
subcutaneously
implanted
nude
mice.
combination
therapy,
intravenously
injected
under
field
guidance
followed
NIR
laser
irradiation
demonstrated
most
modality
inhibiting
tumor
growth
prolonging
time
tumor-bearing
Nanotheranostics,
Год журнала:
2024,
Номер
8(2), С. 219 - 238
Опубликована: Янв. 1, 2024
In
2020,
approximately
10
million
deaths
worldwide
were
attributed
to
cancer,
making
it
the
primary
cause
of
death
globally.Photothermal
therapy
(PTT)
is
one
novel
ways
treat
and
abolish
cancer.PTT
significantly
impacts
cancer
theranostics
compared
other
therapies
like
surgery,
chemotherapy,
radiotherapy
due
its
remarkable
binding
capability
tumor
sites
lower
invasiveness
into
normal
healthy
tissues.PTT
relies
on
photothermal
agents
(PTAs),
which
generate
heat
by
absorbing
near-infrared
(NIR)
light
destroying
cells.Several
PTT
remain
longer
in
reticuloendothelial
system
(RES)
induce
toxicity,
restricting
their
use
biomedical
field.To
overcome
this
problem,
usage
biodegradable
nano-photothermal
required.This
review
has
discussed
mechanism
action
different
types
bio-nanomaterials
used
for
PTT.We
also
focussed
combinatorial
effects
with
effect
human
health.The
role
LED
lights
mild
hypothermia
been
briefly
review.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5637 - 5680
Опубликована: Июнь 1, 2024
Abstract:
Photodynamic
therapy
(PDT)
is
a
non-invasive
that
has
made
significant
progress
in
treating
different
diseases,
including
cancer,
by
utilizing
new
nanotechnology
products
such
as
graphene
and
its
derivatives.
Graphene-based
materials
have
large
surface
area
photothermal
effects
thereby
making
them
suitable
candidates
for
PDT
or
photo-active
drug
carriers.
The
remarkable
photophysical
properties
of
derivates
facilitate
the
efficient
generation
reactive
oxygen
species
(ROS)
upon
light
irradiation,
which
destroys
cancer
cells.
Surface
functionalization
can
also
enhance
their
biocompatibility
anticancer
activity.
paper
delves
into
distinct
roles
played
graphene-based
photosensitizers
(PS)
carriers
while
at
same
time
considers
how
these
could
be
used
to
circumvent
resistance.
This
will
provide
readers
with
an
extensive
discussion
various
pathways
contributing
inefficiency.
Consequently,
this
comprehensive
review
underscores
vital
derivatives
may
play
emerging
strategies
treatment
other
medical
purposes.
With
better
comprehension
current
state
research
existing
challenges,
integration
holds
great
promise
developing
targeted,
effective,
personalized
treatments.
Keywords:
quantum
dots,
oxide,
research,
photosensitizers,
delivery
