Macromolecular Materials and Engineering,
Год журнала:
2023,
Номер
308(10)
Опубликована: Июль 12, 2023
Abstract
With
the
increasing
interest
in
biopolymer
nanofibers
for
diverse
applications,
characterization
of
these
materials
physiological
environment
has
become
equal
and
importance.
This
study
performs
first‐time
simulated
body
fluid
(SBF)
degradation
tensile
mechanical
analyses
blended
fish
gelatin
(FGEL)
polycaprolactone
(PCL)
nanofibrous
meshes
prepared
by
a
high‐throughput
free‐surface
alternating
field
electrospinning.
The
thermally
crosslinked
FGEL/PCL
with
84–96%
porosity
up
to
60
wt%
PCL
fraction
demonstrate
mass
retention
88.4%
after
14
days
SBF.
trends
crystallinity
FGEL
secondary
structure
modification
during
SBF
are
analyzed
Fourier
transform
infrared
spectroscopy.
Tensile
tests
such
porous,
0.1–2.2
mm
thick
reveal
ultimate
strength,
Young's
modulus,
elongation
at
break
within
ranges
60–105
kPa,
0.3–1.6
MPa,
20–70%,
respectively,
depending
on
ratio.
results
that
from
poorly
miscible
can
be
suitable
selected
biomedical
applications
as
scaffolds
skin,
cranial
cruciate
ligament,
articular
cartilage,
or
vascular
tissue
repair.
Biomacromolecules,
Год журнала:
2025,
Номер
26(1), С. 654 - 669
Опубликована: Янв. 1, 2025
Cross-linking
bonds
adjacent
polymer
chains
into
a
three-dimensional
network.
Cross-linked
poly(vinyl
alcohol)
(PVA)
turns
hydrogel,
insoluble
structure
exhibiting
outstanding
sorption
properties.
As
an
electrospinnable
polymer,
PVA
enables
the
creation
of
nanofibrous
hydrogels
resembling
biological
tissues,
thus
ideal
for
nature-inspired
platforms.
properties
are
easily
adjustable
through
additives
and
appropriate
cross-linking
method.
Drawing
inspiration
from
environmentally
safe
approaches,
this
work
developed
new
"green"
method
low-temperature
cross-linking.
Nanofibers
were
electrospun
precursor
solution
dissolved
in
fresh
lemon
juice,
stabilized
by
heating
at
60
°C
7
days,
thoroughly
characterized.
The
obtained
nanoplatform
demonstrated
long-term
stability
enhanced
mechanical
Its
biocompatibility
was
confirmed,
its
antibacterial
health-promoting
effects
attributed
to
juice-rich
vitamin
C,
potent
antioxidant
with
anti-inflammatory
system
has
future
potential
use
biomedical
engineering
field
as
dressing
accelerating
wound
healing.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Management
of
infected
diabetic
wounds
with
large
amounts
biofluid
is
challenging
to
treat
due
localized
edema-induced
ischemia.
Traditional
hydrophilic
dressings
retain
wound
exudate,
raise
bacterial
infection,
and
hinder
healing.
Herein,
a
multifunctional
double-layer
Janus
fibrous
hydrogel
hydrophobic
superhydrophilic
potential
was
designed
accelerate
the
healing
wounds.
The
outer
layer
composed
poly(vinylidene
fluoride)/cellulose
acetate-based
nanofibrous
composite.
In
contrast,
inner
photo-cross-linked
gelatin
methacrylate/polycaprolactone
based
coated
zinc-dopamine-based
metal-phenolic
network
complex.
bilayer
characterized
for
its
structural,
physicochemical,
mechanical,
swelling,
antioxidant,
antibacterial,
cytocompatibility
properties.
Results
indicated
that
possesses
excellent
antifouling
self-cleaning
can
prevent
entry
environmental
microorganisms
moisture.
On
other
hand,
supramolecular
complex
good
cell-supportive
Furthermore,
evaluated
by
using
BALB/c
mice.
in
vivo
invasions
histological
immunological
results
reconstruction
potential,
angiogenesis,
collagen
deposition,
making
it
appropriate
treatment.
Materials Today Advances,
Год журнала:
2024,
Номер
21, С. 100465 - 100465
Опубликована: Фев. 7, 2024
Hydrogels
have
emerged
as
promising
biomaterials
for
nerve
regeneration
due
to
their
adjustable
properties,
structural
resemblance
the
extracellular
matrix,
and
ability
promote
cell
adhesion
proliferation.
This
comprehensive
review
discusses
advantages,
challenges,
future
directions
of
various
functional
hydrogels.
Advanced
technologies
fabricating
Multistructured
hydrogel,
including
injectable
hydrogels,
hydrogel
microspheres,
fibrous
3D
printing
nanogels,
stem
cell-loaded
electrical
ultrasound
magnetic
been
developed
studied
regeneration.
These
demonstrate
versatility
hydrogels
in
neural
tissue
repair.
However,
challenges
such
biocompatibility,
degradation
rates,
scaffold
design
need
be
addressed.
Interdisciplinary
research
is
necessary
develop
innovative
systems
that
overcome
these
realize
potential
provides
valuable
insights
into
advanced
highlights
regenerative
medicine,
particularly
Researchers
can
use
this
knowledge
refine
therapeutic
approaches
involving
enhancing
Nano Letters,
Год журнала:
2024,
Номер
24(39), С. 12014 - 12026
Опубликована: Сен. 10, 2024
Owing
to
its
multiple
fascinating
properties
of
renewability,
biodegradability,
biocompatibility,
and
antibacterial
activity,
chitin
is
expected
become
a
green
cornerstone
next-generation
functional
materials.
Chitin
nanofibers,
as
building
blocks,
form
multiscale
hierarchical
structures
spanning
nano-
macrolevels
in
living
organisms,
which
pave
the
way
for
sophisticated
functions.
Therefore,
from
biomimetic
perspective,
exploiting
nanofibers
use
multifunctional,
high-performance
materials
promising
approach.
Here,
we
first
summarize
latest
advances
structure
assembly
mode
derivative
including
top-down
exfoliation
bottom-up
synthesis.
Subsequently,
emphasize
environmental
impacts
these
methods,
are
crucial
whether
can
truly
contribute
more
eco-friendly
era.
Furthermore,
progress
medical
applications
also
discussed.
Finally,
potential
challenges
tailored
solutions
further
proposed,
covering
raw
material,
structure,
function,
manufacturing,
policies,
etc.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 8, 2025
Monitoring
wound
infection
and
providing
appropriate
treatment
are
crucial
for
achieving
favorable
outcomes.
However,
the
time-consuming
nature
of
laboratory
culture
tests
may
delay
timely
intervention.
To
tackle
this
challenge,
a
simple
yet
effective
HDG
hydrogel,
composed
hydrogen
peroxide
(H₂O₂),
dopamine,
GelMA
polymer,
is
developed
ultrafast
detection
Staphylococcus
aureus
(SA)
infections.
The
hydrogel
detects
SA
by
exploiting
its
secreted
catalase
to
catalyze
H₂O₂,
producing
oxygen,
which
in
turn
accelerates
polymerization
colorless
dopamine
into
deep
brown
polydopamine
(PDA).
bacterial
process
takes
only
10
min
with
high
sensitivity,
results
can
be
readily
recognized
naked
eye
or
quantified
using
cell
phone-based
digital
analysis.
Moreover,
provides
dual
antibacterial
mechanism
through
chemical
photothermal
therapies
via
generated
PDA,
significantly
improving
clearance.
In
animal
experiments,
demonstrated
promising
capabilities
monitoring
eliminating
bacteria,
enhancing
collagen
deposition,
reducing
inflammation,
promoting
healing
infected
wounds.
This
multifunctional
design
offers
an
enzyme-responsive
strategy
rapid
assessment
management
infections,
simplifying
evaluation
facilitating
development
advanced
dressings.
Carbohydrate Polymers,
Год журнала:
2023,
Номер
315, С. 120934 - 120934
Опубликована: Апрель 20, 2023
Peripheral
nerve
repair
following
injury
is
one
of
the
most
serious
problems
in
neurosurgery.
Clinical
outcomes
are
often
unsatisfactory
and
associated
with
a
huge
socioeconomic
burden.
Several
studies
have
revealed
great
potential
biodegradable
polysaccharides
for
improving
regeneration.
We
review
here
promising
therapeutic
strategies
involving
different
types
their
bio-active
composites
promoting
Within
this
context,
polysaccharide
materials
widely
used
forms
highlighted,
including
guidance
conduits,
hydrogels,
nanofibers
films.
While
conduits
hydrogels
were
as
main
structural
scaffolds,
other
films
generally
additional
supporting
materials.
also
discuss
issues
ease
implementation,
drug
release
properties
outcomes,
together
future
directions
research.
Abstract
Spider
silk,
possessing
exceptional
combination
properties,
is
classified
as
a
bio‐gel
fiber.
Thereby,
it
serves
valuable
origin
of
inspiration
for
the
advancement
various
artificial
gel
fiber
materials
with
distinct
functionalities.
Gel
fibers
exhibit
promising
potential
utilization
in
diverse
fields,
including
smart
textiles,
muscle,
tissue
engineering,
and
strain
sensing.
However,
there
are
still
numerous
challenges
improving
performance
functionalizing
applications
spider
silk‐inspired
fibers.
Thus,
to
gain
penetrating
insight
into
bioinspired
fibers,
this
review
provided
comprehensive
overview
encompassing
three
key
aspects:
fundamental
design
concepts
implementing
strategies
properties
strengthening
functionalities
application
prospects
In
particular,
multiple
toughening
mechanisms
were
introduced
at
micro,
nano,
molecular‐level
structures
Additionally,
existing
summarized.
This
aims
offer
significant
guidance
development
inspire
further
research
field
high‐performance
