Investigation of the Effect of Preparation Parameters on the Structural and Mechanical Properties of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated by the Combined Foaming and Freeze-Drying Techniques DOI Open Access

Mansour T. Qamash,

S. Misagh Imani,

Meisam Omidi

и другие.

Journal of Composites Science, Год журнала: 2024, Номер 8(10), С. 408 - 408

Опубликована: Окт. 4, 2024

This paper aimed to evaluate the effects of different preparation parameters, including agitation speed, time, and chilling temperature, on structural mechanical properties a novel gelatin/elastin/sodium hyaluronate tissue engineering scaffold, recently developed by our research group. Fabricated using combination foaming freeze-drying techniques, scaffolds were assessed understand how these parameters influence their morphology, internal microstructure, porosity, properties, degradation behavior. The fabrication process used in this study involved preparing homogeneous aqueous solution containing 8% gelatin, 2% elastin, 0.5% sodium (w/v), which was then subjected at speeds 500, 1000, 1500 rpm for durations 5, 15, 25 min. mixture subsequently frozen −20 °C −80 °C, followed cross-linking. Morphological analyses laser microscopy scanning electron (SEM) demonstrated that had pore sizes ranging from 100 300 µm, are conducive effective cell interaction regeneration. confirmed efficacy combined method creating highly interconnected porous structures. Our findings indicated temperature slightly influenced size. In contrast, higher longer duration times led increased porosity rate but decreased modulus. Mathematical estimators compressive modulus statistical analysis parameters. validated experimentally, with error between estimated experimental values being less than 6% 21%

Язык: Английский

Bioinspired Composite Hydrogels with Osteogenic, Angiogenic, and Antioxidant Properties for Enhanced Bone Repair DOI Creative Commons

Guanghui Gu,

Youyin Xu,

Peng He

и другие.

Small Structures, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

The increasing demand of advanced biomedical materials for bone repair and regeneration has spurred significant research in recent years. While traditional hydrogels offer promising biocompatibility easy fabrication, their application reconstruction is often impeded by inadequate structural integrity biological functions. Graphene oxide (GO) emerged as a transformative additive, renowned its exceptional mechanical chemical properties, well ability to enhance the hydrogels. In this study, incorporation GO into chitosan (CS) investigated, achieving bioinspired with enhanced strength stability, which are crucial supporting regeneration. Additionally, self‐assembled synthetic peptide nanofibers (PNFs) employed facilitate biomimetic mineralization hydrogels, critical process effective remodeling. This innovative composite hydrogel not only achieves but also exhibits osteogenic, pro‐angiogenic, antioxidant properties essential repair. novel method takes advantage distinctive GO, PNFs, biomass providing robust material solution potential significantly advance field tissue engineering.

Язык: Английский

Процитировано

1
3D-Printed Polycaprolactone-Based Containing Calcium Zirconium Silicate: Bioactive Scaffold for Accelerating Bone Regeneration DOI Open Access

Hosein Emadi,

Mostafa Baghani,

Maryam Masoudi Rad

и другие.

Polymers, Год журнала: 2024, Номер 16(10), С. 1389 - 1389

Опубликована: Май 13, 2024

There is an essential clinical need to develop rapid process scaffolds repair bone defects. The current research presented the development of calcium zirconium silicate/polycaprolactone for tissue engineering utilising melt extrusion-based 3D printing. Calcium silicate (CZS) nanoparticles were added polycaprolactone (PCL) porous enhance their biological and mechanical properties, while resulting properties studied extensively. No significant difference was found in melting point samples, crystallisation temperature points samples containing bioceramic increased from 36.1 40.2 °C. Thermal degradation commenced around 350 °C all materials. According our results, increasing CZS content 0 40 wt.% (PC40) (porosity about 55–62%) improved compressive strength 2.8 10.9 MPa. Furthermore, apatite formation ability SBF solution significantly by enhancing percentage. MTT test viability MG63 cells remarkably (~29%) PC40 compared pure PCL. These findings suggest that a 3D-printed PCL/CZS composite scaffold can be fabricated successfully shows great potential as implantable material applications.

Язык: Английский

Процитировано

7
3D-Printed Polycaprolactone/Nano Bredigite Scaffolds with Varying Bredigite Content for Enhanced Bone Tissue Engineering DOI
Mehdi Kheradmandfard, Seyed Farshid Kashani-Bozorg, Seyed Ali Poursamar

и другие.

Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 106534 - 106534

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1
4D Biofabrication of Magnetically Augmented Callus Assembloid Implants Enables Rapid Endochondral Ossification via Activation of Mechanosensitive Pathways DOI Creative Commons
Konstantinos Ioannidis, Andreas Dimopoulos, Isaak Decoene

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Abstract The use of magnetic‐driven strategies for non‐contact manipulation engineered living modules opens up new possibilities tissue engineering. integration magnetic nanoparticles (MNPs) with cartilaginous microtissues enables model‐driven 4D bottom‐up biofabrication remotely actuated assembloids, providing unique properties to mechanoresponsive tissues, particularly skeletal constructs. However, clinical use, the long‐term effects stimulation on phenotype and in vivo functionality need further exploration. Magnetic‐driven includes both rapid processes, such as guided microtissue assembly, slower biological like extracellular matrix secretion. This work explores interplay between fields MNP‐loaded through mathematical modeling experimental approaches, investigating ECM maturation chondrogenic hypertrophy. Transcriptomic analysis reveal that activated mechanosensitive pathways catabolic driving accelerated cartilage‐to‐bone transitions via endochondral ossification, outcomes not observed non‐stimulated controls. study paves way pre‐programmed, assembloids superior bone‐forming capacity regenerating challenging bone fractures.

Язык: Английский

Процитировано

0
Surface modification of 3D-printed polylactic acid-hardystonite scaffold for bone tissue engineering DOI

Danial Shirali,

Rahmatollah Emadi, Mohammad Khodaei

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142496 - 142496

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Recent progress of antibacterial strategy for 3D-printed bone repair scaffold DOI
Xiaojie Chen, Xinyu Li, Qing Li

и другие.

Surfaces and Interfaces, Год журнала: 2025, Номер 66, С. 106601 - 106601

Опубликована: Апрель 30, 2025

Язык: Английский

Процитировано

0
Improvement in Surface Morphology and Mechanical Properties of the Polycaprolactone/ Hydroxyapatite/ Graphene Oxide Scaffold: 3D Printing - Salt Leaching Method DOI Creative Commons

Shahrzad Shiran,

Mohammad Sadegh Nourbakhsh, Mohsen Setayeshmehr

и другие.

Journal of Materials Research and Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Investigation of the Effect of Preparation Parameters on the Structural and Mechanical Properties of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated by the Combined Foaming and Freeze-Drying Techniques DOI Open Access

Mansour T. Qamash,

S. Misagh Imani,

Meisam Omidi

и другие.

Journal of Composites Science, Год журнала: 2024, Номер 8(10), С. 408 - 408

Опубликована: Окт. 4, 2024

This paper aimed to evaluate the effects of different preparation parameters, including agitation speed, time, and chilling temperature, on structural mechanical properties a novel gelatin/elastin/sodium hyaluronate tissue engineering scaffold, recently developed by our research group. Fabricated using combination foaming freeze-drying techniques, scaffolds were assessed understand how these parameters influence their morphology, internal microstructure, porosity, properties, degradation behavior. The fabrication process used in this study involved preparing homogeneous aqueous solution containing 8% gelatin, 2% elastin, 0.5% sodium (w/v), which was then subjected at speeds 500, 1000, 1500 rpm for durations 5, 15, 25 min. mixture subsequently frozen −20 °C −80 °C, followed cross-linking. Morphological analyses laser microscopy scanning electron (SEM) demonstrated that had pore sizes ranging from 100 300 µm, are conducive effective cell interaction regeneration. confirmed efficacy combined method creating highly interconnected porous structures. Our findings indicated temperature slightly influenced size. In contrast, higher longer duration times led increased porosity rate but decreased modulus. Mathematical estimators compressive modulus statistical analysis parameters. validated experimentally, with error between estimated experimental values being less than 6% 21%

Язык: Английский

Процитировано

0