Hydrogels with Antioxidant Microparticles Systems Based on Hyaluronic Acid for Regenerative Wound Healing

Macromolecular Bioscience, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Abstract This research focuses on the synthesis of hydrogels exhibiting enhanced antioxidant properties derived from hyaluronic acid (HA) and poly(ethylene brassylate‐co‐squaric acid) (PEBSA), a copolymacrolactone that have ability to be used in drug delivery applications. Quercetin (Q), bioflavonoid with strong properties, is employed as bioactive compound. The biomolecule encapsulated polymeric network using different entrapment techniques, including initial formation complex between PEBSA Q, which demonstrated through dynamic light scattering technique. Fourier transform infrared spectroscopy (FT‐IR) rheological studies confirm hydrogels, revealing occurrence physical interactions synthetic polymer polysaccharide. Moreover, demonstrate biocompatible after direct contact HDFa cell line revealed by DPPH tests.

Язык: Английский

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State‐of‐the‐Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment

Advanced NanoBiomed Research, Год журнала: 2024, Номер unknown

Опубликована: Июнь 23, 2024

The slow healing process of diabetic wound due to persisting infections in bed, owing hyperglycemia, makes the search for efficient treatments pending. While it is complicated increase closure rate diabetic‐related wounds complex pathology, treatment such with hydrogels seen as a promising approach and pursued over years. However, where this research currently standing terms clinical translation these different multifunctional stimuli‐responsive hydrogel bandages accelerate foot ulcer help improve life patients future management? This perspective article will review some most important advancements field conclude perspectives, considered relevant context.

Язык: Английский

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Advances in rationally engineered cytokines for precision therapy in diabetic wound healing

Exploration of Immunology, Год журнала: 2024, Номер 4(4), С. 533 - 553

Опубликована: Авг. 28, 2024

Diabetic wound healing presents a unique and complex challenge due to the impaired cellular molecular functions associated with diabetes. Chronic wounds in diabetic patients are characterized by prolonged inflammation, reduced angiogenesis, collagen deposition, which significantly hinder process. This comprehensive review focuses on innovative applications of designer cytokines precision therapy for healing, emphasizing remarkable advancements made overcoming limitations natural cytokines, such as their short half-life, potential cytotoxicity, lack specificity. We begin detailing intricate biological characteristics essential role that play orchestrating The critically examines constraints traces evolution synthetic alternatives, particular emphasis peptide-based nucleic acid-based artificial cytokines. Advanced strategies designing these discussed, including modifications, functional enhancements, specificity improvements better target pathological conditions wounds. Furthermore, we explore utilization biology techniques engineer effective cytokine-based therapies. promising therapeutic rationally designed is highlighted, showcasing ability modulate microenvironment, enhance tissue regeneration, reduce chronic inflammation. not only provides valuable perspectives future research directions but also offers insights into clinical therapies, aiming improve outcomes suffering from

Язык: Английский

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Photothermal and Immunomodulatory Hydrogels Loaded with Black Phosphorus Nanosheets and Curcumin for Wound Healing

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(21), С. 25107 - 25123

Опубликована: Окт. 28, 2024

In the field of skin wound treatment, traditional methods are often limited by dual challenges effectively clearing bacterial infections and accelerating healing. To address these issues, this study developed an innovative bioactive hydrogel that combines photothermally responsive antimicrobial immunomodulatory effects. The utilized methacrylated gelatin oxidized dextran, forming a stable network structure through radical Schiff bonds, loaded with black phosphorus (BP) nanosheets curcumin (Cur). Characterization hydrogel's physicochemical properties revealed not only its excellent swellability, biodegradability, mechanical strength, thermal stability, antioxidative but also ability to control release Cur photothermal effect. Under 808 nm NIR irradiation, suitable effect was observed BP at concentration 250 μg/mL under power density 1.5 W/cm2, conversion efficiency (η) 41.34%. vitro experiments showed exhibited bactericidal rate over 90% against E. coli, S. aureus, P. aeruginosa more than 80% antibiofilm formation activity. After coculturing HUVEC cells for 24 48 h, cell viability remained above 80%. Cell migration assay confirmed effectiveness in promoting (closure reached 97.4% within h). rat model infected wounds, it shown on day 14, wounds were nearly healed, antibacterial 85%, expression levels proinflammatory factors TNF-α IFN-γ reduced, anti-inflammatory IL-4 TGF-β1 increased, re-epithelialization observed, collagen deposited, which facilitated rapid healing wounds. capabilities offers efficient strategy treating

Язык: Английский

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San Huang Xiao Yan recipe promoted wound healing in diabetic ulcer mice by inhibiting Th17 cell differentiation

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 119243 - 119243

Опубликована: Дек. 1, 2024

Язык: Английский

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3D bioprinting of a dermal scaffold for full-thickness skin tissue regeneration

Bio-Design and Manufacturing, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Язык: Английский

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