Dexmedetomidine alleviates intestinal ischemia/reperfusion injury by modulating intestinal neuron autophagy and mitochondrial homeostasis via Nupr1 regulation
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Ноя. 6, 2024
Abstract
Intestinal
ischemia/reperfusion
injury
(I/R)
is
a
common
yet
challenging-to-treat
condition,
presenting
significant
clinical
challenge.
This
study
aims
to
investigate
the
protective
mechanisms
of
Dexmedetomidine
(Dex)
against
I/R
injury,
with
particular
focus
on
its
role
in
regulating
autophagy
activity
intestinal
neurons
and
maintaining
mitochondrial
homeostasis.
Experimental
findings
demonstrate
that
Dex
can
mitigate
damage
induced
by
through
modulation
function
suppressing
expression
Nupr1.
discovery
sheds
light
new
molecular
mechanism
underlying
potential
efficacy
treating
offering
valuable
insights
for
therapy.
Язык: Английский
Deciphering the Molecular Pathways: How Polygonatum sibiricum Alleviates Myocardial Ischemia
Zhanzhan Zhu,
Junzhi Pan,
Bin Jiang
и другие.
Journal of Food Biochemistry,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Herbal
medicine,
like
Polygonatum
sibiricum
,
is
gaining
attention
for
its
potential
in
treating
myocardial
ischemia.
Comprehensive
research
on
molecular
interplay
essential
development
as
a
therapeutic
agent.
The
aim
to
investigate
the
mechanisms
by
which
ameliorates
study
involves
thorough
database
exploration,
docking,
and
use
of
both
vivo
vitro
models
detailed
assessment.
role
HIF‐1α
pathway
particularly
emphasized.
Identification
11
principal
components
23
core
proteins,
with
dominant
HIF‐1α,
was
achieved.
A
notable
improvement
conditions,
attributable
observed.
improves
ischemic
injury
augmenting
mitochondrial
activity
enhancing
pathway.
Язык: Английский
Effect of VBIT-4 on the functional activity of isolated mitochondria and cell viability
Biochimica et Biophysica Acta (BBA) - Biomembranes,
Год журнала:
2024,
Номер
1866(5), С. 184329 - 184329
Опубликована: Апрель 27, 2024
Язык: Английский
Insights into the Regulation of the Mitochondrial Inheritance and Trafficking Adaptor Protein Mmr1 in Saccharomyces cerevisiae
Kinases and Phosphatases,
Год журнала:
2024,
Номер
2(2), С. 190 - 208
Опубликована: Июнь 18, 2024
Mitochondria
are
organelles
involved
in
cellular
energetics
all
eukaryotes,
and
changes
their
dynamics,
fission,
fusion,
or
localization
can
lead
to
cell
defects
disease
humans.
Budding
yeast,
Saccharomyces
cerevisiae,
has
been
shown
be
an
effective
model
organism
elucidating
mechanisms
underpinning
these
mitochondrial
processes.
In
the
work
presented
here,
a
genetic
screen
was
performed
identify
overexpressing
kinases,
phosphatases,
ubiquitin
ligases,
which
resulted
defects.
A
total
of
33
overexpressed
genes
showed
phenotypes
but
without
severe
growth
These
included
subset
that
affected
timing
inheritance
were
focus
further
study.
Using
biochemical
approaches,
roles
PAK-family
kinase
Cla4
E3-ubiquitin
ligases
Dma1
Dma2
investigated.
Previous
studies
have
indicated
triggering
degradation
trafficking
adaptors
bud,
leads
disruption
interaction
with
transporting
class
V
myosin,
Myo2.
Here,
we
map
key
interface
between
adaptor
Mmr1
necessary
for
phosphorylation
region
required
its
via
Dma2.
Together,
our
data
provide
insights
into
regulatory
regions
responsible
function
inheritance.
Язык: Английский