Glioprotective Effects of Sulforaphane in Hypothalamus: Focus on Aging Brain
Neurochemical Research,
Год журнала:
2024,
Номер
49(9), С. 2505 - 2518
Опубликована: Июнь 17, 2024
Язык: Английский
Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease
Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1601 - 1601
Опубликована: Ноя. 27, 2024
Metformin
is
a
commonly
used
drug
for
treating
type
2
diabetes.
an
inexpensive
with
low/no
side
effects
and
well
tolerated
in
human
patients
of
different
ages.
Recent
therapeutic
strategies
disease
have
considered
the
benefits
repurposing.
This
includes
use
anti-diabetic
metformin.
Accordingly,
anti-inflammatory,
anti-cancer,
anti-viral,
neuroprotective,
cardioprotective
potentials
metformin
deemed
it
suitable
candidate
plethora
diseases.
As
results
from
preclinical
studies
using
cellular
animal
model
systems
appear
promising,
clinical
trials
context
non-diabetes-related
illnesses
been
started.
Here,
we
aim
to
provide
comprehensive
overview
potential
models
its
suggested
relationship
epigenetics
ailments
epigenetic
components.
Язык: Английский
Sexual Dimorphism and Hypothalamic Astrocytes: Focus on Glioprotection
Neuroglia,
Год журнала:
2024,
Номер
5(3), С. 274 - 288
Опубликована: Авг. 2, 2024
Sexual
dimorphism
refers
to
biological
differences
between
males
and
females
in
the
same
species,
including
morphological,
physiological,
behavioral
characteristics.
Steroid
hormones
are
associated
with
changes
several
brain
regions,
as
well
pathophysiology
of
aging,
obesity,
neuropsychiatric
diseases.
The
hypothalamus
controls
physiological
processes,
metabolism,
reproduction,
circadian
rhythm,
body
homeostasis.
Refined
communication
neurons
glial
cells,
particularly
astrocytes,
coordinates
hypothalamic
functions.
Therefore,
from
previously
published
studies,
this
review
aims
highlight
sex-related
rodent
since
we
believe
that
region
is
essential
for
understanding
dimorphic
patterns
influenced
by
steroid
sex
hormones.
Thus,
concepts
sexual
dimorphism,
hypothalamic-pituitary-gonadal
axis,
role
hormonal
influence
on
astrocyte
functions,
neuroglial
communication,
disorders
glioprotective
mechanisms
hypothalamus.
Язык: Английский
Astrocyte dysfunction alters GABAergic communication and ammonia metabolism in the streptozotocin-induced sporadic Alzheimer's disease model
Journal of Alzheimer s Disease Reports,
Год журнала:
2024,
Номер
8(1), С. 1381 - 1393
Опубликована: Март 1, 2024
Background
In
the
sporadic
model
of
Alzheimer's
disease
(AD),
induced
by
intracerebroventricular
streptozotocin
(STZ)
administration,
cognitive
impairment
is
accompanied
specific
astrocytic
changes
in
hippocampus
prior
to
amyloid
deposition.
Objective
Hypothesizing
that
synthesis
GABA,
via
MAO-B,
contributes
ammonia
elevation,
thereby
compromising
antioxidant
defense
and
ATP
synthesis,
possibly
contributing
damage,
we
determined
hippocampal
levels
glutamine
synthetase
(GS),
monoamine
oxidase
B
(MAO-B)
other
enzymes
related
GABA
metabolism.
Methods
Immunoblotting
RT-PCR
assays
were
carried
out
samples
Wistar
rats,
at
4
16
weeks
post-STZ,
STZ-induced
AD
model,
corresponding
pre-amyloid
phases,
respectively.
Results
We
observed
a
reduction
GS
activity
increased
MAO-B
content,
both
weeks,
reinforcing
idea
astroglial
dysfunction
precedes
phase.
These
alterations
an
increase
content
ornithine
decarboxylase
1
(ODC1),
which
catalyzes
putrescine
(substrate
for
MAO-B),
gene
expression
arginine-glycine
amidinotransferase
(AGAT),
enzyme
involved
creatine,
generation
agonists.
only
seen
phase
model.
Conclusions
Our
findings
contribute
explain
greater
damage
occurs
energy
metabolism
this
stage,
addition
GABAergic
loss.
The
reinforce
importance
STZ
further
our
understanding
phases.
Язык: Английский