Photocurrent‐Directed Immunoregulation Accelerates Osseointegration through Activating Calcium Influx in Macrophages DOI Creative Commons
Yizhou Zhu, Chaofeng Wang,

Can Ai

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(46)

Опубликована: Окт. 4, 2024

Abstract Early osteoimmune microenvironment disorder at the interface between bone and implant can lead to loosening, which prolongs patient convalescence, exacerbates postoperative complications, potentially results in failure. The timely regulation of macrophages primarily orchestrates entire long‐term regeneration process. Here, it is proposed precisely direct macrophage polarization using localized photoelectrical signals generated by an excitable surface response remote stimulation via near‐infrared light (NIR). photocurrent from n–n heterojunction calcium titanate (CaTiO 3 ) defective titanium dioxide (TiO 2 ‐V o on accurately polarization, suppressing acute inflammation early stage post‐implantation establishing a favorable that promotes bone‐to‐implant integration. Mechanistic study reveals photoelectric initiate increased influx voltage‐gated ion channels, subsequently modulating calcium/calmodulin‐dependent protein kinase (Camkk2) I (Camk1) expression regulate polarization. This optimization enhanced mesenchymal stem cells (MSCs) recruitment osteogenesis, ultimately accelerating integration within 14 days post‐implantation. research presents novel method for adjusting vivo spatiotemporal immune responses through use noninvasive externally‐controlled targeted stimulations.

Язык: Английский

R-Q@P-D nanoparticle for improving the oral bioavailability and therapeutic efficacy: A novel reversible dual-target-mild-inhibition intestinal metabolic enzymes strategy for resveratrol delivery DOI

Qingchen Cui,

Yanling Li,

Liping Zhou

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154662 - 154662

Опубликована: Авг. 11, 2024

Язык: Английский

Процитировано

0
Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues DOI Creative Commons

Pengzhen Zhuang,

Yang Wu, Yu Chen

и другие.

Biomedical Technology, Год журнала: 2024, Номер 8, С. 17 - 49

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Photocurrent‐Directed Immunoregulation Accelerates Osseointegration through Activating Calcium Influx in Macrophages DOI Creative Commons
Yizhou Zhu, Chaofeng Wang,

Can Ai

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(46)

Опубликована: Окт. 4, 2024

Abstract Early osteoimmune microenvironment disorder at the interface between bone and implant can lead to loosening, which prolongs patient convalescence, exacerbates postoperative complications, potentially results in failure. The timely regulation of macrophages primarily orchestrates entire long‐term regeneration process. Here, it is proposed precisely direct macrophage polarization using localized photoelectrical signals generated by an excitable surface response remote stimulation via near‐infrared light (NIR). photocurrent from n–n heterojunction calcium titanate (CaTiO 3 ) defective titanium dioxide (TiO 2 ‐V o on accurately polarization, suppressing acute inflammation early stage post‐implantation establishing a favorable that promotes bone‐to‐implant integration. Mechanistic study reveals photoelectric initiate increased influx voltage‐gated ion channels, subsequently modulating calcium/calmodulin‐dependent protein kinase (Camkk2) I (Camk1) expression regulate polarization. This optimization enhanced mesenchymal stem cells (MSCs) recruitment osteogenesis, ultimately accelerating integration within 14 days post‐implantation. research presents novel method for adjusting vivo spatiotemporal immune responses through use noninvasive externally‐controlled targeted stimulations.

Язык: Английский

Процитировано

0