Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics

Materials Horizons, Год журнала: 2023, Номер 11(1), С. 12 - 36

Опубликована: Окт. 4, 2023

With the increasing and aging of global population, there is a dramatic rise in demand for implants or substitutes to rehabilitate bone-related disorders which can considerably decrease quality life even endanger lives. Though titanium its alloys have been applied as mainstream material fabricate load-bearing bone defect restoration temporary internal fixation devices fractures, it far from rare encounter failed cases clinical practice, particularly with pathological factors involved. In recent years, smart stimuli-responsive (SSR) strategies conducted functionalize improve regeneration conditions, such bacterial infection, chronic inflammation, tumor diabetes mellitus,

Язык: Английский

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Layer-by-layer self-assembly coatings on strontium titanate nanotubes with antimicrobial and anti-inflammatory properties to prevent implant-related infections

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 244, С. 114183 - 114183

Опубликована: Авг. 28, 2024

Язык: Английский

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Relieving Macrophage Dysfunction by Inhibiting SREBP2 Activity: A Hypoxic Mesenchymal Stem Cells‐Derived Exosomes Loaded Multifunctional Hydrogel for Accelerated Diabetic Wound Healing

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 21, 2024

Abstract Macrophage dysfunction is one of the primary factors leading to delayed healing diabetic wounds. Hypoxic bone marrow mesenchymal stem cells‐derived exosomes (hyBMSC‐Exos) have been shown play an active role in regulating cellular function through carried microRNAs. However, administration hyBMSC‐Exos alone wounds usually brings little effect, because are inherently unstable and a short retention time at In this study, multifunctional hydrogel based on gallic acid (GA) conjugated chitosan (Chi‐GA) partially oxidized hyaluronic (OHA) prepared for sustained release hyBMSC‐Exos. The not only exhibits needs‐satisfying physicochemical properties, but also displays outstanding biological performances such as low hemolysis rate, strong antibacterial capacity, great antioxidant ability, excellent biocompatibility. It has ability boost stability hyBMSC‐Exos, continuous gradual wound locations, ultimately enhancing exosomes’ uptake efficiency by target cells. Most importantly, loaded shows promote macrophage polarization toward M2 phenotype. This may be exosomal miR‐4645‐5p property synergistically inhibit SREBP2 activity macrophages. study presents productive approach managing

Язык: Английский

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Tailoring Photoweldable Shape Memory Polyurethane with Intrinsic Photothermal / Fluorescence Via Engineering Metal‐Phenolic Systems

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 9, 2024

Abstract Multifunctional shape memory polymers are significant for next‐generation intelligent systems as smart materials. However, their practical applications limited by toughness, manufacturability, and functional integration strategies. Besides, while 4D printing is used to construct deformable devices, the accessible shapes difficulty of integrating multiple materials hindered development multifunctional devices. Herein, metal‐phenolic coordination crosslinks tailor tough polyurethanes with intrinsic photothermal effect and/or tunable fluorescence. The reversible dissociation complexes upon loading provides an efficient energy dissipation polymer network. photothermal/fluorescent properties target polyurethane can be effortlessly programmed changing coordinated metals ligands. obtained fluorescent displays fluorescence through dissociation‐association dynamic bonds thermal stimulus. Moreover, relying on light‐triggered hybrid exchange reactions among various bonds, heterogeneous interfaces merged manufacture exquisite 3D shape‐shifting devices integrate more advanced functions. As demonstrations, photothermal‐responsive stent, encryption device produced based photo‐welding instead printing. This study not only a convenient supramolecular strategy constructing but also demonstrates feasible method making personalized integrated architectures.

Язык: Английский

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3D-printed bone scaffolds containing graphene oxide/gallium nanocomposites for dual functions of anti-infection and osteogenesis differentiation

Surfaces and Interfaces, Год журнала: 2025, Номер 57, С. 105770 - 105770

Опубликована: Янв. 1, 2025

Язык: Английский

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A Versatile Chitosan‐Based Hydrogel Accelerates Infected Wound Healing via Bacterial Elimination, Antioxidation, Immunoregulation, and Angiogenesis

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Фев. 26, 2024

Abstract Drug‐resistant bacterial infection of cutaneous wounds causes great harm to the human body. These infections are characterized by a microenvironment with recalcitrant infections, persistent oxidative stress, imbalance immune regulation, and suboptimal angiogenesis. Treatment strategies available date incapable handling healing dynamics infected wounds. A Schiff base borate ester cross‐linked hydrogel, based on phenylboronic acid‐grafted chitosan (CS‐PBA), dibenzaldehyde‐grafted poly(ethylene glycol), tannic acid (TA), is fabricated in present study. Customized acid‐modified zinc oxide nanoparticles (ZnO) embedded hydrogel prior gelation. The CPP@ZnO‐P‐TA effectively eliminates methicillin‐resistant Staphylococcus aureus (MRSA) due pH‐responsive release Zn 2+ TA. Killing achieved via membrane damage, adenosine triphosphate reduction, leakage intracellular components, hydrolysis o ‐nitrophenyl‐β‐ d ‐galactopyranoside. capable scavenging reactive oxygen nitrogen species, alleviating stimulating M2 polarization macrophages. released TA also induce neovascularization PI3K/Akt pathway. improves tissue regeneration vivo inflammatory responses, angiogenesis, facilitating collagen deposition. findings suggest that this versatile possesses therapeutic potential for treatment MRSA‐infected

Язык: Английский

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A pH/ROS-responsive antioxidative and antimicrobial GelMA hydrogel for on-demand drug delivery and enhanced osteogenic differentiation in vitro

International Journal of Pharmaceutics, Год журнала: 2024, Номер 657, С. 124134 - 124134

Опубликована: Апрель 20, 2024

Язык: Английский

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Sericin-based conductive hydrogel loaded with MXene@TA-Eu nanosheets promotes the healing of infected wounds through photothermal antibacterial and electrical stimulation

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159738 - 159738

Опубликована: Янв. 1, 2025

Язык: Английский

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Magnesium alloy with superhydrophilic magnesium/gallium-layered double hydroxides coating with antibacterial property as implant material

Journal of Nanoparticle Research, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 1, 2025

Язык: Английский

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From ROS scavenging to boosted osseointegration: cerium-containing mesoporous bioactive glass nanoparticles functionalized implants in diabetes

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 18, 2024

Excessive production of reactive oxygen species (ROS) around titanium implants under diabetic conditions causes persistent inflammation, leading to poor osseointegration and even implant failure. Surface modification is an effective way promote ROS clearance, alleviate stimulate bone formation. In this study, a multifunctional coating fabricated by introducing cerium (Ce)-containing mesoporous bioactive glass nanoparticles (Ce-MBGNs) onto the surface via electrophoretic deposition method. The incorporation Ce-MBGNs remarkably improves hydrophilicity increasing areas. ions are appropriately released, thereby promoting mesenchymal stem cell proliferation differentiation conditions. conversion between Ce(III) Ce(IV) endows with antioxidative nanoenzymes properties scavenge diabetes-induced ROS, resulting in macrophage polarization towards anti-inflammatory phenotype. therapeutic effect Ce-MBGNs-modified also verified rats inhibiting inflammatory responses accelerating early osseointegration. Taken together, findings reveal that ROS-scavenging immunomodulation activity contributes enhanced osseointegration, provides novel for patients.

Язык: Английский

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