ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(14), С. 17242 - 17252
Опубликована: Апрель 1, 2024
Protective
autophagy
and
DNA
damage
repair
lead
to
tumor
radio-resistance.
Some
hypoxic
tumors
exhibit
a
low
radiation
energy
absorption
coefficient
in
therapy.
High
doses
of
X-rays
may
side
effects
the
surrounding
normal
tissues.
In
order
overcome
radio-resistance
improve
efficacy
radiotherapy
based
on
characteristics
microenvironment,
development
radiosensitizers
has
attracted
much
attention.
this
study,
Janus
ACSP
nanoparticle
(NP)
was
developed
for
chemodynamic
therapy
radiosensitization.
The
reactive
oxygen
species
generated
by
Fenton-like
reaction
regulated
distribution
cell
cycles
from
radioresistant
phase
radio-sensitive
phase.
high-Z
element,
Au,
enhanced
production
hydroxyl
radicals
(•OH)
under
X-ray
radiation,
promoting
apoptosis.
NP
delayed
interfering
with
certain
proteins
involved
signaling
pathway.
vivo
experiments
demonstrated
that
combination
copper-ion-based
low-dose
effectiveness
radiotherapy,
providing
novel
approach
synergistic
radiosensitization
This
study
provides
valuable
insights
strategies
application
NPs
cancer
treatment.
RSC Advances,
Год журнала:
2024,
Номер
14(21), С. 14722 - 14741
Опубликована: Янв. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
Biometallic
ions
play
a
crucial
role
in
regulating
the
immune
system.
In
recent
years,
cancer
immunotherapy
has
become
breakthrough
treatment,
achieving
good
efficacy
wide
range
of
cancers
with
its
specificity
and
durability
advantages.
However,
existing
therapies
still
face
challenges,
such
as
tolerance
escape.
(e.g.
zinc,
copper,
magnesium,
manganese,
etc.)
can
assist
enhancing
through
activation
cells,
enhancement
tumor
antigen
presentation,
improvement
microenvironment.
addition,
biometallic
derivatives
directly
inhibit
cell
progression
offer
possibility
effectively
overcoming
limitations
current
by
promoting
responses
reducing
immunosuppressive
signals.
This
review
explores
potential
application
prospects
immunotherapy,
providing
new
ideas
for
future
clinical
metal
part
helping
to
guide
development
more
effective
safe
therapeutic
regimens.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Abstract
Abnormal
expression
of
transmembrane
mucin
16
(MUC16)
in
ovarian
cancer
(OC)
can
promote
progression
epithelial–mesenchymal
transformation,
enhance
tumor
cell
proliferation,
migration,
and
invasion.
Therefore,
herein
a
targeted
therapeutic
high‐valence
selenium
(Se)
nanomedicine
(MUC16‐SeMnf@Res)
is
designed,
which
target
MUC16
to
recognize
OC
simultaneously
inhibit
achieve
efficient
treatment
OC.
The
valence
bidirectional
editing
strategy
used
design
synthesize
Se
nanosystem
(SeMnf)
through
triggering
redox
reaction
between
triclinic
manganese
dioxide
nanoflower
(Mnf),
inducing
the
conversion
4+
Mn
2+
.
increased
ratio
within
SeMnf
disrupt
intracellular
homeostasis
by
glutathione
(GSH)
depletion
reactive
oxygen
species
(ROS)
overproduction.
Moreover,
effects
ROS
overproduction
are
further
amplified
loaded
resveratrol
(Res),
significantly
induces
mitochondrial
dysfunction
inhibited
expression,
then
promoting
caspase‐activated
apoptosis
as
well
migration
inhibitory.
Taken
together,
this
study
not
only
sheds
light
on
important
role
designing
OC‐targeting
drugs,
but
also
provides
simple
translational
developing
nanotherapeutics
with
strong
redox‐homeostasis
disrupting
capability
realize
MUC16‐targeting
therapy.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 30, 2025
Previously,
we
demonstrated
that
natural
host-defence
peptide
caerin
1.1/caerin
1.9
(F1/F3)
increases
the
efficacy
of
anti-PD-1
and
therapeutic
vaccine,
in
a
HPV16
+
TC-1
tumour
model,
but
anti-tumor
mechanism
F1/F3
is
still
unclear.
In
this
study,
explored
impact
on
tumor
microenvironment
transplanted
B16
melanoma
further
investigated
action
using
monoclonal
antibodies
to
deplete
relevant
cells,
gene
knockout
mice
flow
cytometry.
We
show
able
inhibit
growth
cells
both
vitro
vivo.
Depletion
macrophages,
blockade
IFNα
receptor,
Stat1
inhibition
each
abolishes
F1/F3-mediated
antitumor
responses.
Subsequent
analysis
reveals
infiltration
inflammatory
upregulates
level
promotes
secretion
by
macrophages.
Interestingly,
CD47
cells;
blocking
Furthermore,
intratumor
injection,
blockade,
vaccination
significantly
survival
time
tumour-bearing
mice.
These
results
indicate
may
be
effective
improve
ICB
vaccine-based
immunotherapy
for
human
epithelial
cancers
warrants
consideration
clinical
trials.
Biomaterials Research,
Год журнала:
2025,
Номер
29
Опубликована: Янв. 1, 2025
Tumors
are
the
second
most
common
cause
of
mortality
globally,
ranking
just
below
heart
disease.
With
continuous
advances
in
diagnostic
technology
and
treatment
approaches,
survival
rates
some
cancers
have
increased.
Nevertheless,
due
to
complexity
mechanisms
underlying
tumors,
cancer
remains
a
serious
public
health
issue
that
threatens
population
globally.
Manganese
(Mn)
is
an
essential
trace
element
for
human
body.
Its
regulatory
role
tumor
biology
has
received
much
attention
recent
years.
Developments
nanotechnology
led
emergence
Mn-based
nanoparticles
great
potential
use
diagnosis
cancers.
nanomaterials
can
be
integrated
with
conventional
techniques,
including
chemotherapy,
radiation
therapy,
gene
augment
their
therapeutic
effectiveness.
Further,
play
synergistic
emerging
strategies
such
as
immunotherapy,
photothermal
photodynamic
electromagnetic
hyperthermia,
sonodynamic
chemodynamic
intervention
therapy.
Moreover,
enhance
both
precision
diagnostics
capability
combined
treatment.
This
article
examines
roles
associated
Mn
field
physiology
biology,
focus
on
application
prospects
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 8, 2025
Radiotherapy
(RT)
is
the
primary
treatment
modality
for
nasopharyngeal
carcinoma
(NPC).
However,
tumor
microenvironment
(TME)-induced
radioresistance
often
compromises
its
therapeutic
efficacy.
Herein,
we
propose
an
innovative
bidirectional
radiosensitization
strategy
NPC.
Specifically,
have
encapsulated
metformin
(Met)
and
copper
sulfide
nanoparticles
(CuS
NPs)
within
injectable
DNA
supramolecular
hydrogels
(DSH)
to
create
a
novel
radiosensitizer,
Met-CuS@DSH.
This
radiosensitizer
not
only
effectively
reverses
hypoxia
promote
reactive
oxygen
species
(ROS)
generation
but
also
significantly
inhibits
glutathione
(GSH)-mediated
ROS
scavenging,
thereby
achieving
by
enhancing
production
suppressing
scavenging.
improves
effect
of
NPC
while
reducing
RT
dose
(3
Gy
in
total),
which
provides
promising
approach
overcoming
caused
TME.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Radiation
colitis
is
an
inflammatory
response
induced
by
damage
to
colonic
tissue
from
radiation
therapy
that
primarily
affects
patients
undergoing
abdominal
or
pelvic
treatments.
In
this
study,
we
designed
a
selenium-loaded
probiotic
(EcN-Se@SA)
encapsulated
in
sodium
alginate
gel
for
the
oral
treatment
of
colitis.
Selenium
nanoparticles
(Se
NPs)
exhibit
antioxidant,
anti-inflammatory,
ferroptosis,
and
repair-promoting
properties.
To
enhance
therapeutic
efficacy
Se
NPs
radiation-induced
colitis,
combined
with
Escherichia
coli
Nissle
1917
them
hydrogel.
The
resulting
EcN-Se@SA
formulation
not
only
withstands
gastric
acid
intestinal
fluids
but
also
remains
colon
cecum
extended
periods.
Oral
administration
attenuates
X-ray-induced
mice
through
its
antioxidant
anti-inflammatory
effects,
macrophage
reprogramming,
inhibition
ferroptosis
histiocytes.
This
work
introduces
promising
candidate
