Journal of Ethnopharmacology, Год журнала: 2024, Номер 340, С. 119258 - 119258
Опубликована: Дек. 19, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 17, 2024
Abstract Gastric ulcers accompanied by acute or chronic bleeding represent a significant risk of fatality. However, the development effective strategies for achieving rapid hemostasis and wound healing in gastric ulcer represents formidable challenge. To address this challenge, thrombin‐derived C‐terminal peptide (TCP‐25) is employed as targeted agent, it incorporated into two novel injectable biocompatible carboxymethyl chitosan (CMCs) hydrogels via Schiff's base reaction. The TCP‐25 display optimal adaptability within distinctive gastrointestinal microenvironment, demonstrating balance acid resistance degradation, along with controlled release bioactivity, good bio‐adhesive properties. Both vitro vivo reveal that hydrogel achieves hemostasis. In an ethanol‐induced model rats, demonstrates effectively inhibits 92% 24‐h, exhibiting efficacy surpasses omeprazole medicine, commonly used clinical treatment. This enhanced performance attributed to synergistic effects CMCs hemostasis, inhibiting bacterial growth, promoting ulcers. Consequently, present work offers promising applications
Язык: Английский
Процитировано
6
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
Hydrogel bioadhesives with adequate wet adhesion and swelling resistance are urgently needed in clinic. However, the presence of blood or body fluid usually weakens interfacial bonding strength, even leads to failure. Herein, profiting from unique coupling structure carboxylic phenyl groups one component (N-acryloyl phenylalanine) for drainage matrix toughening as well various electrostatic interactions mediated by zwitterions, a novel hydrogel adhesive (PAAS) is developed superior tissue properties challenging conditions (adhesion strength 85 kPa, toughness 450 J m
Язык: Английский
Процитировано
4
Microchimica Acta, Год журнала: 2025, Номер 192(2)
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114572 - 114572
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3399 - 3417
Опубликована: Март 1, 2025
Background: Electroacupuncture (EA) is a promising treatment for gastrointestinal disorders, yet the efficacy of different acupoint combinations remains mechanistically undefined. We evaluated therapeutic effects on mucosal inflammatory injury induced in rat model gastric ulcer (GU) and dissected its molecular mechanisms through transcriptomic profiling. Methods: A GU was established using hypothermic restrained water immersion stress. EA therapy administered to He-Mu (ST36-CV12), Shu-Mu (BL21-CV12), Yuan-Luo (ST42- ST40) 5 days. were by coat score, fecal moisture percentage, pain threshold, body mass, organ index, histopathological changes, serum level oxidative stress, cytokine levels tissue. transcriptome analysis identified related differentially expressed genes (DEGs) central signaling pathway. Real-time quantitative PCR Western blot performed verify mRNA protein expression main Results: alleviated rats, with group exhibiting superior tissue damage alleviation, as well inflammation stress reductions. Venn diagram revealed shared pathway among three groups, corresponding focal adhesion. Quantitative validation confirmed that mRNA, protein, phosphorylated FAK, VCL, EGFR—the core signal transduction factors adhesion activated after treatment—were upregulated, consistent their efficacy. Conclusion: Our results demonstrated combination exhibited combinations. improved varying degrees, The VCL , EGFR are targets, further studies needed elucidate functional consequences GU. Keywords: electroacupuncture, ulcer, combinations, profiling,
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер 321, С. 123320 - 123320
Опубликована: Апрель 5, 2025
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Ноя. 14, 2024
Bioactive peptides hold significant potential for enhancing human health, however, their limited oral bioavailability poses a substantial barrier to widespread use in the food and pharmaceutical industries. This article reviews key factors influencing absorption efficiency of bioactive peptides, including issues related bitter taste perception, challenges gastrointestinal environmental stability, limitations transmembrane transport. Furthermore, it highlights latest technologies, such as osmotic technology, chemical modification, advanced delivery systems, discusses advantages stability facilitating intestinal absorption. In addition, application common systems liposomes, emulsions, polymer nanoparticles, hydrogels peptide are also discussed. paper aims provide theoretical foundation scientific research practical applications thereby promoting further development context health.
Язык: Английский
Процитировано
3
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)
Опубликована: Дек. 1, 2024
ABSTRACT Recent advancements in naturally derived bioadhesives have transformed their application across diverse medical fields, including tissue engineering, wound management, and surgery. This review focuses on the innovative development multifunctional nature of these bioadhesives, particularly emphasizing role enhancing adhesion performance wet environments optimizing mechanical properties for use dynamic tissues. Key areas covered include chemical physical mechanisms adhesion, incorporation multi‐adhesion strategies that combine covalent non‐covalent bonding, bioinspired designs mimicking natural adhesives such as those barnacles mussels. Additionally, discusses emerging applications regeneration musculoskeletal, cardiac, neural, ocular tissues, highlighting potential bioadhesive‐based therapies complex biological settings. Despite substantial progress, challenges scaling lab‐based innovations clinical overcoming environmental constraints remain critical. Ongoing research bioadhesive technologies aims to bridge gaps, promising significant improvements tailored therapeutic needs.
Язык: Английский
Процитировано
3
Colloids and Interface Science Communications, Год журнала: 2024, Номер 63, С. 100809 - 100809
Опубликована: Окт. 31, 2024
Язык: Английский
Процитировано
2
Journal of Ethnopharmacology, Год журнала: 2024, Номер 340, С. 119258 - 119258
Опубликована: Дек. 19, 2024
Язык: Английский
Процитировано
0