In Situ Crystallized Ceria‐Vesicle Nanohybrid Therapeutic for Effective Treatment of Inflammatory Intraocular Disease DOI Open Access
Jiawei Zhao, Yingjie Wang, Yiquan Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Abstract Posterior uveitis is a leading cause of vision impairment and blindness globally due to its detrimental effects on the choroid retina. The condition worsened by oxidative stress, which heightens inflammation perpetuates cycle damage that current treatments only temporarily relieve. To address this, novel treatment involving in situ crystallization ultrasmall cerium oxide nanoparticles (≈3 nm) mesenchymal stem cell (MSC) extracellular vesicles (EVs) for management primed mycobacterial (PMU) developed. This nanohybrid leverages individual synergistic components comprehensive therapeutic approach. act as nanozyme reduce scavenge excessive reactive oxygen species (ROS), while MSC EVs, with their biocompatibility, modulate inflammatory infiltration alleviate tissue damage. system offers promising new strategy ocular diseases characterized stress inflammation.

Язык: Английский

A Photoactivated Self‐Assembled Nanoreactor for Inducing Cascade‐Amplified Oxidative Stress toward Type I Photodynamic Therapy in Hypoxic Tumors DOI

Xuan Luo,

Qishu Jiao,

Shicheng Pei

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Abstract Type I photodynamic therapy (PDT) generates reactive oxygen species (ROS) through oxygen‐independent photoreactions, making it a promising method for treating hypoxic tumors. However, the superoxide anion (O 2 ∙ – ) generated usually exhibits low oxidation capacity, restricting antitumor efficacy of PDT in clinical practice. Herein, photoactivated self‐assembled nanoreactor ( 1 ‐NBS@CeO is designed integration type and cerium oxide (CeO nanozymes inducing cascade‐amplified oxidative stress The constructed though co‐assembly an amphiphilic peptide ‐NBS) CeO , giving well‐dispersed spherical nanoparticles with enhanced dismutase (SOD)‐like peroxidase (POD)‐like activities. Following light irradiation, undergoes photoreactions to O which further catalyzed by nanoreactors, ultimately forming hypertoxic hydroxyl radical (∙OH) reactions. treatment using results elevation intracellular ROS depletion GSH content A375 cells, thereby mitochondrial dysfunction triggering apoptosis ferroptosis tumor cells. Importantly, intravenous administration alongside irradiation showcases enhances satisfactory biocompatibility vivo. Together, facilitates achieving efficacious PDT, holds great promise developing therapeutic modules towards

Язык: Английский

Процитировано

4

Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications DOI Creative Commons

Svetlana A. Titova,

Maria Petrovna Kruglova, Stupin Va

и другие.

Molecules, Год журнала: 2025, Номер 30(6), С. 1210 - 1210

Опубликована: Март 8, 2025

Rare earth metal nanoparticles, some of which are already widely used in medicine, growing interest the modern scientific community. One promising rare metals for biomedical applications is cerium, specifically its oxide form, characterized by a higher level stability and safety. According to number studies, cerium dioxide has wide range biological effects (regenerative, antimicrobial, antioxidant, antitumor), justifies potential application medicine. However, these their intensity vary significantly across studies. Since was it can be assumed that not only chemical formula important, but also physicochemical parameters nanoparticles obtained, consequently methods synthesis modification with use excipients. In this review, we considered possibilities using excipients (polyacrylate, polyvinylpyrrolidone, dextran, hyaluronic acid, chitosan, polycarboxylic acids, lecithin, phosphatidylcholine) context preserving properties, as well degree study combinations from point view prospect creating drugs based on applications.

Язык: Английский

Процитировано

0

Müller Glial‐Derived Small Extracellular Vesicles Mitigate RGC Degeneration by Suppressing Microglial Activation via Cx3cl1‐Cx3cr1 Signaling DOI Open Access

Hai‐Dong Qian,

Xiangyuan Song,

Guiqiong He

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Retinal ganglion cell (RGC) degeneration leads to irreversible blindness. Müller glia (MG) play pivotal roles in retinal homeostasis and disease through paracrine signaling. Small extracellular vesicles (sEVs) are bioactive nanomaterials derived from all types of live cells recognized as a potential strategy for neuroprotective therapy. The aim this study is investigate the MG-derived sEVs (MG-sEVs) mouse model optic nerve injury (ONC). It found that MG-sEVs treatment effectively mitigates RGC suppresses microglial activation, thereby improves visual function ONC mice. transcriptomic analysis reveals strong correlation between C-x3-c motif chemokine ligand 1 (Cx3cl1)-mediated glial activation inflammation. Subsequently, it confirmed expression levels Cx3cl1 proinflammatory cytokines significantly decreased retinas treated with MG-sEVs. components cargo identifies miR-125b-5p miR-16-5p target gene regulate its expression. also observed colocalizes on microglia transgenic receptor (Cx3Cr1)-GFP In conclusion, mitigate by suppressing via Cx3cl1-Cx3cr1 This research provides additional opportunities degeneration.

Язык: Английский

Процитировано

0

MicroRNA-loaded Antioxidant Nanoplatforms for Prevention and Treatment of Experimental Acute and Chronic Uveitis DOI
Si-Ting Sheng,

Huiling Zhao,

Lirui Liu

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123353 - 123353

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

The emerging role of nanozymes in ocular antioxidant therapy DOI
Xue Bai,

Yu Lu,

Shuyu Wang

и другие.

Nano Today, Год журнала: 2024, Номер 58, С. 102448 - 102448

Опубликована: Авг. 23, 2024

Язык: Английский

Процитировано

2

In Situ Crystallized Ceria‐Vesicle Nanohybrid Therapeutic for Effective Treatment of Inflammatory Intraocular Disease DOI Open Access
Jiawei Zhao, Yingjie Wang, Yiquan Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Abstract Posterior uveitis is a leading cause of vision impairment and blindness globally due to its detrimental effects on the choroid retina. The condition worsened by oxidative stress, which heightens inflammation perpetuates cycle damage that current treatments only temporarily relieve. To address this, novel treatment involving in situ crystallization ultrasmall cerium oxide nanoparticles (≈3 nm) mesenchymal stem cell (MSC) extracellular vesicles (EVs) for management primed mycobacterial (PMU) developed. This nanohybrid leverages individual synergistic components comprehensive therapeutic approach. act as nanozyme reduce scavenge excessive reactive oxygen species (ROS), while MSC EVs, with their biocompatibility, modulate inflammatory infiltration alleviate tissue damage. system offers promising new strategy ocular diseases characterized stress inflammation.

Язык: Английский

Процитировано

1