A Photoactivated Self‐Assembled Nanoreactor for Inducing Cascade‐Amplified Oxidative Stress toward Type I Photodynamic Therapy in Hypoxic Tumors
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 5, 2024
Abstract
Type
I
photodynamic
therapy
(PDT)
generates
reactive
oxygen
species
(ROS)
through
oxygen‐independent
photoreactions,
making
it
a
promising
method
for
treating
hypoxic
tumors.
However,
the
superoxide
anion
(O
2
∙
–
)
generated
usually
exhibits
low
oxidation
capacity,
restricting
antitumor
efficacy
of
PDT
in
clinical
practice.
Herein,
photoactivated
self‐assembled
nanoreactor
(
1
‐NBS@CeO
is
designed
integration
type
and
cerium
oxide
(CeO
nanozymes
inducing
cascade‐amplified
oxidative
stress
The
constructed
though
co‐assembly
an
amphiphilic
peptide
‐NBS)
CeO
,
giving
well‐dispersed
spherical
nanoparticles
with
enhanced
dismutase
(SOD)‐like
peroxidase
(POD)‐like
activities.
Following
light
irradiation,
undergoes
photoreactions
to
O
which
further
catalyzed
by
nanoreactors,
ultimately
forming
hypertoxic
hydroxyl
radical
(∙OH)
reactions.
treatment
using
results
elevation
intracellular
ROS
depletion
GSH
content
A375
cells,
thereby
mitochondrial
dysfunction
triggering
apoptosis
ferroptosis
tumor
cells.
Importantly,
intravenous
administration
alongside
irradiation
showcases
enhances
satisfactory
biocompatibility
vivo.
Together,
facilitates
achieving
efficacious
PDT,
holds
great
promise
developing
therapeutic
modules
towards
Язык: Английский
Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications
Molecules,
Год журнала:
2025,
Номер
30(6), С. 1210 - 1210
Опубликована: Март 8, 2025
Rare
earth
metal
nanoparticles,
some
of
which
are
already
widely
used
in
medicine,
growing
interest
the
modern
scientific
community.
One
promising
rare
metals
for
biomedical
applications
is
cerium,
specifically
its
oxide
form,
characterized
by
a
higher
level
stability
and
safety.
According
to
number
studies,
cerium
dioxide
has
wide
range
biological
effects
(regenerative,
antimicrobial,
antioxidant,
antitumor),
justifies
potential
application
medicine.
However,
these
their
intensity
vary
significantly
across
studies.
Since
was
it
can
be
assumed
that
not
only
chemical
formula
important,
but
also
physicochemical
parameters
nanoparticles
obtained,
consequently
methods
synthesis
modification
with
use
excipients.
In
this
review,
we
considered
possibilities
using
excipients
(polyacrylate,
polyvinylpyrrolidone,
dextran,
hyaluronic
acid,
chitosan,
polycarboxylic
acids,
lecithin,
phosphatidylcholine)
context
preserving
properties,
as
well
degree
study
combinations
from
point
view
prospect
creating
drugs
based
on
applications.
Язык: Английский
Müller Glial‐Derived Small Extracellular Vesicles Mitigate RGC Degeneration by Suppressing Microglial Activation via Cx3cl1‐Cx3cr1 Signaling
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Retinal
ganglion
cell
(RGC)
degeneration
leads
to
irreversible
blindness.
Müller
glia
(MG)
play
pivotal
roles
in
retinal
homeostasis
and
disease
through
paracrine
signaling.
Small
extracellular
vesicles
(sEVs)
are
bioactive
nanomaterials
derived
from
all
types
of
live
cells
recognized
as
a
potential
strategy
for
neuroprotective
therapy.
The
aim
this
study
is
investigate
the
MG-derived
sEVs
(MG-sEVs)
mouse
model
optic
nerve
injury
(ONC).
It
found
that
MG-sEVs
treatment
effectively
mitigates
RGC
suppresses
microglial
activation,
thereby
improves
visual
function
ONC
mice.
transcriptomic
analysis
reveals
strong
correlation
between
C-x3-c
motif
chemokine
ligand
1
(Cx3cl1)-mediated
glial
activation
inflammation.
Subsequently,
it
confirmed
expression
levels
Cx3cl1
proinflammatory
cytokines
significantly
decreased
retinas
treated
with
MG-sEVs.
components
cargo
identifies
miR-125b-5p
miR-16-5p
target
gene
regulate
its
expression.
also
observed
colocalizes
on
microglia
transgenic
receptor
(Cx3Cr1)-GFP
In
conclusion,
mitigate
by
suppressing
via
Cx3cl1-Cx3cr1
This
research
provides
additional
opportunities
degeneration.
Язык: Английский
MicroRNA-loaded Antioxidant Nanoplatforms for Prevention and Treatment of Experimental Acute and Chronic Uveitis
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123353 - 123353
Опубликована: Апрель 1, 2025
Язык: Английский
The emerging role of nanozymes in ocular antioxidant therapy
Nano Today,
Год журнала:
2024,
Номер
58, С. 102448 - 102448
Опубликована: Авг. 23, 2024
Язык: Английский
In Situ Crystallized Ceria‐Vesicle Nanohybrid Therapeutic for Effective Treatment of Inflammatory Intraocular Disease
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Abstract
Posterior
uveitis
is
a
leading
cause
of
vision
impairment
and
blindness
globally
due
to
its
detrimental
effects
on
the
choroid
retina.
The
condition
worsened
by
oxidative
stress,
which
heightens
inflammation
perpetuates
cycle
damage
that
current
treatments
only
temporarily
relieve.
To
address
this,
novel
treatment
involving
in
situ
crystallization
ultrasmall
cerium
oxide
nanoparticles
(≈3
nm)
mesenchymal
stem
cell
(MSC)
extracellular
vesicles
(EVs)
for
management
primed
mycobacterial
(PMU)
developed.
This
nanohybrid
leverages
individual
synergistic
components
comprehensive
therapeutic
approach.
act
as
nanozyme
reduce
scavenge
excessive
reactive
oxygen
species
(ROS),
while
MSC
EVs,
with
their
biocompatibility,
modulate
inflammatory
infiltration
alleviate
tissue
damage.
system
offers
promising
new
strategy
ocular
diseases
characterized
stress
inflammation.
Язык: Английский