Implantable physical sensors for in vivo organ monitoring

Med-X, Год журнала: 2025, Номер 3(1)

Опубликована: Янв. 8, 2025

Abstract Implantable sensors can provide access to accurate, continuous, and minimally invasive monitoring of physiological signals from internal organs tissues, thereby facilitating timely diagnosis, closed-loop intervention, advanced health management. Among the various types implantable sensors, those capable measuring physical parameters–such as temperature, force, flow–are particularly important due their ability monitor conditions critical nearly all insights into a wide range conditions. This review presents recent progress in four key sensors: strain pressure temperature flow sensors. It covers engineering principles, design considerations, vivo performances, clinical relevance. The also addresses challenges future opportunities development such flexibility stretchability, biocompatibility, long-term stability, translation these sensing technologies bench clinic. Graphical

Язык: Английский

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Salt-welding strategy for the design of repairable impact-resistant and wear-resistant hydrogels

Science Advances, Год журнала: 2025, Номер 11(4)

Опубликована: Янв. 24, 2025

Self-healing hydrogels can autonomously repair damage, enhancing their performance stability and broadening applications as soft devices. Although the incorporation of dynamic interactions enhances self-healing capabilities, it simultaneously weakens hydrogels’ strength. External stimuli such heating, while accelerating healing process, may also lead to dehydration. Developing a stable strategy that combines rapid high mechanical strength is challenging. Here, we introduce “salt-welding” for high-strength with room temperature self-healing. This achieved through borate ester bonds in salt-responsive poly(methacrylamide) hydrogel. The process involves “salt-fusion” convert fractures into viscous liquid swift healing, followed by “salt-concretion” toughen achieve posthealing 23 megapascals 95 minutes at temperature, near 100% efficiency. Leveraging tunable rate, hydrogel be tailored reparable wear-resistant material damping device.

Язык: Английский

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Nanocellulose/Selenoglutathione-Enhanced Antioxidant, Elastic, Antibacterial, and Conductive Hydrogels as Strain Sensors

ACS Sustainable Chemistry & Engineering, Год журнала: 2024, Номер 12(36), С. 13622 - 13633

Опубликована: Авг. 27, 2024

The fabrication of highly antioxidant, elastic, antibacterial, and conductive hydrogels is a significant pursuit in the domain wearable technology. However, achieving these properties simultaneously single hydrogel matrix while maintaining superior sensing capabilities poses substantial challenge. In this study, we developed an advanced with enhanced elasticity, conductivity, antibacterial properties, utilizing natural biodegradable cellulose nanocrystals (CNCs) as reinforcement. This was achieved through synergistic integration glutathione (GSH), selenoglutathione (GSeH), biosynthesized selenium nanoparticles (BioSeNPs), CNC. addition, Saccharomyces boulardii served initial strain, atmospheric room temperature plasma mutagenesis utilized to generate high-yield GSH variant. incorporation GSH, GSeH, BioSeNPs, CNC conferred remarkable antioxidant activity, fatigue resistance, robust properties. study introduces novel methodology for synthesis high-performance hydrogels, paving way their application biomedical engineering sensor

Язык: Английский

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Ten questions Concerning Living Laboratories (LL) for Multi-domain Comfort Investigations

Building and Environment, Год журнала: 2025, Номер unknown, С. 112750 - 112750

Опубликована: Март 1, 2025

Язык: Английский

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Advances in Wearable Electronics for Monitoring Human Organs: Bridging External and Internal Health Assessments

Biomaterials, Год журнала: 2024, Номер 314, С. 122865 - 122865

Опубликована: Сен. 27, 2024

Язык: Английский

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Biophysical insights into the impact of lateral electric field stimulation to cellular microenvironment: Implications for Bioelectronic medicine applications

Biomaterials, Год журнала: 2025, Номер 319, С. 123132 - 123132

Опубликована: Янв. 31, 2025

Язык: Английский

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Spider Silk‐Inspired Conductive Hydrogels for Enhanced Toughness and Environmental Resilience via Dense Hierarchical Structuring

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 4, 2025

Abstract Conductive hydrogels, known for their biocompatibility and responsiveness to external stimuli, hold promise biomedical applications like wearable sensors, soft robotics, implantable electronics. However, broader use is often constrained by limited toughness environmental resilience, particularly under mechanical stress or extreme conditions. Inspired the hierarchical structures of natural materials spider silk, a strategy developed enhance both tolerance in conductive hydrogels. By leveraging multiscale dynamics including pores, crystallization, intermolecular interactions, dense structure created that significantly improves toughness, reaching ≈90 MJ m⁻ 3 . This hydrogel withstands temperatures from −150 70 °C, pressure 12 psi, one‐month storage ambient conditions, while maintaining lightweight profile 0.25 g cm⁻ Additionally, its tunable rheological properties allow high‐resolution printing desired shapes down 220 µm, capable supporting loads exceeding 164 kg 2 study offers versatile framework designing durable various applications.

Язык: Английский

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Antibacterial, Stretchable, and Self‐Adhesive Laponite‐TA Based Conductive Hydrogel Sensor for Human Motion Detection

Journal of Applied Polymer Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

ABSTRACT Due to their biocompatibility and tissue‐like properties, hydrogels have garnered considerable interest in bioelectronics field. Nevertheless, practical implementation is limited by factors such as inadequate mechanical strength, weak interface adhesion, the lack of antimicrobial properties. To address these challenges, a novel conductive hydrogel was synthesized through free radical polymerization, incorporating laponite (LA), tannic acid (TA), polyacrylic (PAA), polyacrylamide (pAAm). An innovative approach employed enhance LA's dispersion ionic liquid (IL) water electrostatic interactions. The integration TA, PAA, PAAm with LA sheets via multiple hydrogen bonds resulted excellent resulting P(AAm‐AA)/IL‐LA/TA exhibits impressive characteristics, including fracture stress 0.44 MPa, strain 1800%. Notably, hydrogel's TA component strong antibacterial activity against Staphylococcus aureus Escherichia coli . This advanced sensor effectively monitors human movements, displaying gauge factor 12.7. Furthermore, its versatile nature facilitates adhesion wide range substrates, making it promising candidate for applications monitoring, electronic devices, medical health surveillance.

Язык: Английский

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Advances in Wearable Biosensors for Wound Healing and Infection Monitoring

Biosensors, Год журнала: 2025, Номер 15(3), С. 139 - 139

Опубликована: Фев. 23, 2025

Wound healing is a complicated biological process that important for restoring tissue integrity and function after injury. Infection, usually due to bacterial colonization, significantly complicates this by hindering the course of enhancing chances systemic complications. Recent advances in wearable biosensors have transformed wound care making real-time monitoring biomarkers such as pH, temperature, moisture, infection-related metabolites like trimethylamine uric acid. This review focuses on recent biosensor technologies designed management. Novel sensor architectures, flexible stretchable electronics, colorimetric patches, electrochemical platforms, enable non-invasive detection changes associated with wounds high specificity sensitivity. These are increasingly combined AI analytics based smartphones can timely personalized interventions. Examples PETAL patch applies multiple sensing mechanisms wide-ranging views status closed-loop systems connect therapeutic devices automate infection control. Additionally, self-powered tap into body heat or energy from biofluids themselves avoid any external batteries thus more effective field use limited resources. Internet Things connectivity allows further support remote sharing data, supporting telemedicine applications. Although developed relatively rapidly their prospects continue expand, regular clinical application stalled significant challenges regulatory, cost, patient compliance, technical problems related accuracy, biofouling, power, among others, need be addressed innovative solutions. The goal synthesize current trends, challenges, future directions monitoring, emphasis potential improve outcomes reduce healthcare burdens. innovations leading way toward next-generation bridging advanced materials science, biotechnology, digital health.

Язык: Английский

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Next-Generation Wearable Technologies: The Rise of Multifunctional Hydrogels in Smart Electronics

Journal of Cleaner Production, Год журнала: 2025, Номер unknown, С. 145265 - 145265

Опубликована: Март 1, 2025

Язык: Английский

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