International Journal of Biological Macromolecules, Год журнала: 2024, Номер 286, С. 138195 - 138195
Опубликована: Дек. 5, 2024
Язык: Английский
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 685, С. 509 - 521
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
0
Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116763 - 116763
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142684 - 142684
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(43), С. 58357 - 58369
Опубликована: Окт. 16, 2024
Sonodynamic therapy (SDT) is a promising treatment modality for breast cancer; however, its effectiveness often impeded by the hypoxic tumor microenvironment owing to an insufficient oxygen supply in solid tumors. To overcome this challenge, we elaborately developed 4T1 tumor-targeted multifunctional nanoagent integrating both dendrimer-structured copper chelating agents and organic sonosensitizers (IR820) into biotin-modified nanoliposome via microfluidic-assisted self-assembly. In particular, aforementioned agent was constructed introducing multiple xanthate groups dendrimer polymer, which showed significant selectivity consumption of intracellular levels. Based on this, nanoliposome-based therapeutic not only disrupted activity mitochondrial complex IV directly inhibit cell proliferation but also suppressed resistance SDT inhibition cellular respiration. Both vitro vivo studies confirmed that designed nanoagents exhibit synergistic effect IR820-mediated SDT. Taken together, approach establishes proof-of-concept construction copper-ion-modulated nanomedicine significantly enhance efficiency oxygen-dependent cancer treatments.
Язык: Английский
Процитировано
3
Accounts of Materials Research, Год журнала: 2024, Номер unknown
Опубликована: Окт. 24, 2024
ConspectusThe significance of cancer stem cells (CSCs), a rare population in tumor tissues, biology and the treatment solid malignancies has been widely appreciated for more than two decades. Due to peculiar self-renewal capability, even one single cell can grow into bulk mass. For this reason, CSCs have long blamed as major culprit initiation, progression, resistance, metastasis, recurrence. Therefore, it postulated that targeting could provide tremendous clinical benefits patients with tumors. Accumulating studies corroborated maintained tight regulation redox homeostasis fate was extremely sensitive elevated oxidative stress. Accordingly, plethora therapeutic drugs generate reactive oxygen species (ROS) leveraged target CSCs. Nonetheless, few or formulations are capable elevating stress achieved success eliminating thus far.Hydroxyethyl starch (HES) utilized plasma volume expander settings 50 years. Owing its merits excellent biocompatibility biodegradability, good water solubility manufacture practice, abundant hydroxy groups easy chemical modifications, HES attracted great attention tumor-targeted drug delivery. Specifically, nanoparticle stabilizer, nanocarrier conjugate chemotherapeutic by stimuli-responsive linkers, hydrophilic polymer link hydrophobic polymers form self-assembled nanoparticles. In Account, we summarize smart nanomedicines, developed our group during past five years, boost CSC elimination. According their effects on homeostasis, categorize these nanomedicines three classes. The first ones excessive ROS, means mitochondria-targeted photodynamic therapy (Mito-PDT), cuproptosis, ferroptosis. second own capability counteract endogenous reducing substances via inhibiting glutaminolysis depleting glutathione (GSH). third types simultaneously amplify ROS generation suppress antioxidant agents through combination strategies Mito-PDT plus inhibition, dynamic (CDT) GSH depletion, CDT depletion well inhibition. These rationally designed not only vitro but also eliminate numerous tumor-bearing mice models vivo, giving novel insights anti-CSC therapy. As is used clinic, hold significant potential translation.
Язык: Английский
Процитировано
1
Materials Chemistry Frontiers, Год журнала: 2024, Номер 8(23), С. 3898 - 3905
Опубликована: Янв. 1, 2024
1-Methylimidazole-modified BODIPY nanoprobes were developed for highly efficient mitochondrial targeting and enhanced photo dynamic therapy.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 286, С. 138195 - 138195
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
0