bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
The
rise
of
antibiotic
resistance,
biofilm
formation,
and
dormant
bacterial
populations
poses
serious
global
health
threats.
Synthetic
antimicrobial
peptide
(AMP)
mimics
offer
promising
alternatives,
though
the
impact
secondary
structures
in
polymeric
AMP
on
efficacy
is
underexplored.
This
study
investigates
chirality-controlled
α-peptide
polymers
(D-PP
DL-PP),
synthesized
via
ring-opening
polymerization
allylglycine
Antibiotics,
Год журнала:
2025,
Номер
14(2), С. 207 - 207
Опубликована: Фев. 18, 2025
The
rapid
rise
of
antibiotic
resistance
has
become
a
global
health
crisis,
necessitating
the
development
innovative
strategies
to
combat
multidrug-resistant
(MDR)
pathogens.
Nanomaterials
have
emerged
as
promising
tools
in
this
fight,
offering
unique
physicochemical
properties
that
enhance
efficacy,
overcome
mechanisms,
and
provide
alternative
therapeutic
approaches.
This
review
explores
diverse
nanomaterial-based
used
resistance,
focusing
on
their
mechanisms
action
practical
applications.
such
metal
nanoparticles,
carbon-based
nanomaterials,
polymeric
nanostructures
exhibit
antibacterial
through
various
pathways,
including
generation
reactive
oxygen
species
(ROS),
disruption
bacterial
membranes,
enhancement
delivery.
Additionally,
ability
nanomaterials
bypass
traditional
biofilm
formation
efflux
pumps,
been
demonstrated
numerous
studies.
also
discusses
synergistic
effects
observed
when
are
combined
with
conventional
antibiotics,
leading
increased
susceptibility
reduced
required
dosages.
By
highlighting
recent
advancements
clinical
applications
nanomaterial-antibiotic
combinations,
paper
provides
comprehensive
overview
how
reshaping
future
therapies.
Future
research
directions
challenges,
toxicity
scalability,
addressed
guide
safer,
more
effective
treatments.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1401 - 1423
Опубликована: Фев. 1, 2025
Abstract:
Kidney
stones
constitute
a
common
condition
impacting
the
urinary
system.
In
clinical
diagnosis
and
management,
traditional
surgical
interventions
pharmacological
treatments
are
primarily
utilized;
however,
these
methods
possess
inherent
limitations.
Presently,
field
of
nanomedicine
is
undergoing
significant
advancements.
The
application
nanomaterials
in
biosensors
enables
accurate
assessment
ion
composition.
Furthermore,
contrast
agents
developed
from
materials
can
improve
signal-to-noise
ratio
enhance
image
clarity.
By
mitigating
oxidative
stress-induced
cellular
damage,
inhibit
formation
kidney
efficacy
drug
delivery
as
effective
carriers.
Additionally,
by
modifying
physical
chemical
properties
bacteria,
effectively
eliminate
bacterial
presence,
thereby
preventing
severe
complications.
This
review
explores
advancements
technology
related
to
early
detection
risk
factors,
diagnosis,
treatment
their
associated
Keywords:
nanomaterials,
stones,
stress,
biomaterial
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 480 - 480
Опубликована: Янв. 8, 2025
This
study
aims
to
provide
evidence
that
when
testing
cellulose
paper
modified
with
copper
particles
(CuPs),
the
particle
size
and
analysis
method
influence
antimicrobial
activity
observed
by
this
material.
Commercial
CuPs
of
nanometric
(2.7
nm,
CuNPs)
micrometric
(2.5
µm,
CuMPs)
were
used
modify
sheets.
incorporated
during
pulp
disintegration
phase
(stage
1)
sheet
formation
process,
according
ISO
5269-1:2005
standard.
Modified
sheets
retained
16%
14%
CuNPs
CuMPs,
respectively.
Additionally,
distributed
randomly
on
fiber
surfaces,
often
forming
aggregates.
Finally,
was
evaluated
using
20645:2004
20743:2013.
The
results
showed
assessed
each
standard
is
conditioned
mechanism
action
and,
therefore,
their
size.
It
concluded
suitable
for
evaluating
antibacterial
effect
paper/CuNPs,
as
nanoparticles
diffuse
from
are
released
into
culture
medium.
In
contrast,
20743:2013
can
be
both
CuNP-
CuMP-based
paper,
it
evaluates
based
direct
interaction
between
bacteria.
Diabetic
wounds
with
chronic
infections
present
a
significant
challenge,
exacerbated
by
the
growing
issue
of
antimicrobial
resistance,
which
often
leads
to
delayed
healing
and
increased
morbidity.
This
study
introduces
novel
silver-zinc
oxide-eugenol
(Ag+ZnO+EU)
nanocomposite,
specifically
designed
enhance
activity
promote
wound
healing.
The
nanocomposite
was
thoroughly
characterized
using
advanced
analytical
techniques,
confirming
its
nanoscale
structure,
stability
chemical
composition.
Ag+ZnO+EU
demonstrated
potent
efficacy
against
range
associated
pathogens,
including
standard
clinical
isolates
Staphylococcus
aureus,
Pseudomonas
aeruginosa
Candida
albicans.
Minimum
inhibitory
concentrations
for
were
significantly
lower
than
those
individual
components,
highlighting
synergistic
effect
nanocomposite.
Time-kill
assays
revealed
rapid
microbial
eradication,
achieving
complete
sterility
within
240-min.
Importantly,
effectively
eliminated
persister-like
cells,
are
typically
resistant
conventional
treatments,
suggesting
potential
solution
persistent
infections.
In
vitro
scratch
human
keratinocyte
cells
that
accelerated
closure,
near-complete
observed
24-h,
indicating
enhanced
cell
migration
tissue
regeneration.
Additionally,
showed
antidiabetic
effects
increasing
glucose
uptake
up
97.21%
in
an
assay
2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)
amino]-2-deoxy-D-glucose,
fluorescent
analog,
applications
beyond
These
findings
highlight
as
promising
candidate
addressing
both
resistance
impaired
diabetic
contexts.
