ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
The
oxygen
consumption
during
chemodynamic
therapy
(CDT)
can
lead
to
severe
cellular
hypoxia,
resulting
in
an
increase
the
hypoxia
inducible
factor-1α
(HIF-1α)
level,
which
hinders
effectiveness
of
CDT
and
induces
tumor
metastasis.
Here,
we
propose
a
strategy
synergistic
between
HIF-1α
inhibitor
avoid
limitations
reduce
risk
Herein,
based
on
coordination
Fe3+
apigenin
(API,
inhibitor),
constructed
hyaluronic
acid
(HA)-modified
API-Fe
nanoparticles
(AF@HA
NPs)
for
synergetic
chemotherapy
glutathione
(GSH)-activated
self-enhancing
CDT.
AF@HA
NPs
have
high
drug
loading
capacity,
stability,
biocompatibility.
Furthermore,
overexpressed
GSH
cancer
cells
Fe2+,
weakened
API
Fe,
promoted
release
chemotherapy.
Fe2+
could
react
with
endogenous
H2O2
generate
hydroxyl
groups
In
addition,
released
inhibit
expression
sensitivity
reactive
species
(ROS),
thereby
achieving
effect
results
vitro
vivo
experiments
indicated
that
effectively
growth
suppress
lung
metastasis
cells.
Cancer Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 25, 2025
Abstract
Copper
is
an
essential
micronutrient
in
the
human
body,
mainly
acting
as
a
crucial
cofactor
required
for
wide
range
of
physiological
processes
across
nearly
all
cell
types.
Recent
advances
revealed
that
tumor
cells
seize
copper
to
fulfill
their
rapid
proliferation,
metastasis,
immune
evasion,
and
so
on
by
reprogramming
regulatory
network,
defined
cuproplasia.
Thus,
targeting
chelation
reduce
levels
has
been
considered
rational
therapy
strategy.
However,
overloaded
ions
could
be
toxic,
which
leads
aggregation
lipoylated
mitochondrial
proteins
depletion
iron‐sulfur
clusters,
ultimately
resulting
death,
termed
cuproptosis.
Upon
its
discovery,
cuproptosis
attracted
great
interest
from
oncologists,
ionophores
exhibits
potential
anti‐tumor
therapy.
In
this
review,
we
present
underlying
mechanisms
involved
cuproplasia
Additionally,
sum
up
chemicals
either
or
cancer
Further
attention
should
paid
distinguishing
patients
who
are
suitable
Cuproptosis,
a
distinct
cell
death
pathway,
has
been
integrated
into
nanomedicine
for
disease
theranostics.
However,
current
nanosystems
inducing
cuproptosis
rely
on
exogenous
toxic
copper
ions,
limiting
the
scope
of
biomaterials.
Developing
nanoplatforms
that
induce
without
holds
substantial
promise.
Here,
we
engineered
two-dimensional
iron
(Fe)
single-atom–doped
molybdenum
disulfide
(MoS
2
)
piezocatalyst
(Fe-MoS
tumor
therapy.
Incorporating
single
Fe
atoms
enhances
MoS
piezoelectric
polarization
via
charge
redistribution
and
modulates
Mo
oxidation
states,
enabling
multifaceted
enzymatic
activities,
including
peroxidase-,
glutathione
oxidase–,
oxidase-,
catalase-like
activities.
Upon
ultrasound
stimulation,
Fe-MoS
nanocatalyst
generates
reactive
oxygen
species
depletes
synergistic
piezocatalytic
enzyocatalytic
effects,
disrupting
ion
homeostasis
cuproptosis,
concurrently
triggering
ferroptosis
ferritinophagy,
which
collectively
suppression.
This
study
represents
first
paradigm
to
introduce
copper-free
initiating
substantially
advancing
applications
in
Abstract
Cancer
remains
one
of
the
leading
causes
death
individuals
globally.
Conventional
treatment
techniques
like
chemotherapy
and
radiation
often
suffer
various
drawbacks
toxicity
drug
resistance.
The
study
cell
has
been
predominantly
focused
on
classical
forms
apoptosis,
but
role
metal
ions
in
governing
controlled
is
a
fascinating
less
explored
area.
Metal‐mediated
process
where
triggers
via
unique
mechanism.
Nanomaterial‐based
strategies
have
gained
attention
for
their
ability
to
deliver
precise
therapeutic
agents
while
also
triggering
Regulated
Cell
Death
(RCD)
mechanisms
cancer
cells.
recently
discovered
metal‐mediated
cuproptosis
ferroptosis
can
be
used
as
they
selectively
drug‐resistant
cancer.
Nano
material‐based
delivery
system
targeted
sites.
In
this
review,
we
given
some
idea
about
mechanism
(ferroptosis
cuproptosis)
how
initiate
deaths
using
nanomaterials
treatment.
Frontiers in Oncology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 6, 2025
Programmed
cell
death
(PCD)
is
closely
related
to
the
occurrence,
development,
and
treatment
of
breast
cancer.
The
aim
this
study
was
investigate
association
between
various
programmed
patterns
prognosis
cancer
(BRCA)
patients.
levels
19
different
deaths
in
were
assessed
by
ssGSEA
analysis,
these
PCD
scores
summed
obtain
PCDS
for
each
sample.
relationship
with
immune
as
well
metabolism-related
pathways
explored.
PCD-associated
subtypes
obtained
unsupervised
consensus
clustering
differentially
expressed
genes
analyzed.
prognostic
signature
(PCDRS)
constructed
best
combination
101
machine
learning
algorithm
combinations,
C-index
PCDRS
compared
30
published
signatures.
In
addition,
we
analyzed
relation
therapeutic
responses.
distribution
cells
explored
single-cell
analysis
spatial
transcriptome
analysis.
Potential
drugs
targeting
key
Cmap.
Finally,
expression
clinical
tissues
verified
RT-PCR.
showed
higher
normal.
Different
groups
significant
differences
pathways.
PCDRS,
consisting
seven
genes,
robust
predictive
ability
over
other
signatures
datasets.
high
group
had
a
poorer
strongly
associated
cancer-promoting
tumor
microenvironment.
low
exhibited
anti-cancer
immunity
responded
better
checkpoint
inhibitors
chemotherapy-related
drugs.
Clofibrate
imatinib
could
serve
potential
small-molecule
complexes
SLC7A5
BCL2A1,
respectively.
mRNA
upregulated
tissues.
can
be
used
biomarker
assess
response
BRCA
patients,
which
offers
novel
insights
monitoring
personalization
Cancer Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Abstract
Copper,
one
of
the
essential
nutrients
for
human
body,
acts
as
an
electron
relay
in
multiple
pathways
due
to
its
redox
properties.
Both
deficiencies
and
excesses
copper
lead
cellular
fragility.
Therefore,
it
can
manifest
pro‐
anti‐cancer
properties
tumors.
is
crucial
clarify
activity
within
cell.
We
have
thoughtfully
summarized
metabolic
activities
from
a
macro
micro
perspective.
Cuproptosis,
well
other
forms
cell
death,
directly
or
indirectly
interfered
with
by
Cu
2+
,
causing
cancer
death.
Meanwhile,
we
did
pan‐cancer
analysis
cuproptosis‐related
genes
further
roles
these
genes.
In
addition,
has
been
found
be
involved
metastasis
cells.
Given
complexity
copper's
role,
are
compelled
ask:
friend
foe?
Up
now,
used
various
clinical
applications,
including
protocols
measurement
concentration
bioimaging
radioactive
64
Cu.
But
therapeutically
still
continuation
old
medicine,
new
possibilities
need
explored,
such
use
nanomaterials.
Some
studies
also
shown
that
considerable
interventional
power
cancers,
which
provides
great
applications
potential
therapy
specific
types.
This
paper
reviews
dual
played
cuproptosis
perspectives
oxidative
stress,
tumor
metastasis,
points
out
value
application
types,
summarizes
testing
imaging
perspective
current
feasible
options
drugs,
emphasizes
prospects
nano‐copper.
