Harnessing Prazosin for Tumors: Liposome Hybrid Nanovesicles Activate Tumor Immunotherapy via Autophagy Inhibition
Biomaterials,
Год журнала:
2025,
Номер
319, С. 123184 - 123184
Опубликована: Фев. 13, 2025
Язык: Английский
Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy
Advanced Science,
Год журнала:
2024,
Номер
12(2)
Опубликована: Ноя. 13, 2024
Helicobacter
pylori
(H.
pylori)
is
a
primary
pathogen
associated
with
gastrointestinal
diseases,
including
gastric
cancer.
The
increase
in
resistance
to
antibiotics,
along
the
adverse
effects
caused
by
complicated
medication
protocols,
has
made
eradication
of
H.
more
formidable
challenge,
necessitating
alternative
therapeutics.
Herein,
targeted
nanoplatform
reported
based
on
sonodynamic
therapy,
chitosan-conjugated
fucose
loaded
indocyanine
green
(ICG@FCS).
It
penetrates
mucosa
and
homes
through
dual
targeting
mechanisms:
molecular
via
physical
ultrasound.
Upon
ultrasound
activation,
it
generates
singlet
oxygen,
effectively
attacking
planktonic
bacteria,
disrupting
biofilms,
facilitating
clearance
intracellular
bacteria
promoting
autophagy,
multidrug-resistant
strains.
ICG@FCS
minimally
affects
gut
microbiota
aids
repair.
holistic
integrative
therapy
strategy
proposed
that
targets
while
preserving
health.
This
emphasizes
importance
maintaining
patient
health
eradicating
pathogen.
advancement
set
refine
comprehensive
antibacterial
approach,
offering
promising
horizon
ongoing
battle
against
antibiotic
effective
cancer
prevention
strategies.
Язык: Английский
Biocompatible lipid nanovehicles for preventive and therapeutic vaccine development
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
538, С. 216718 - 216718
Опубликована: Апрель 22, 2025
Язык: Английский
Clinical Translation Challenges and Strategies for Tumour Vaccines Considering Multiple Delivery Routes
Vaccines,
Год журнала:
2025,
Номер
13(5), С. 469 - 469
Опубликована: Апрель 27, 2025
Background:
The
high
incidence
and
mortality
rates
of
cancer
have
kept
it
at
the
top
research
agenda
for
global
healthcare
industry,
as
well
put
serious
economic
pressure
on
families
society.
It
has
gradually
been
recognised
that
reducing
through
various
interventions
combining
prevention
treatment
are
key
to
alleviating
burden
cancer.
Methods:
Retrieve
summarize
literature
related
delivery
methods
tumor
vaccines,
investigate
whether
these
applied
clinically
or
used
in
clinical
trials.
Results:
there
a
variety
vaccine
development,
but
only
very
small
number
studies
able
make
strides
towards
implementing
clinic,
which
is
closely
linked
drawbacks
with
means
delivery.
Conclusions:
This
review
analyses
reasons
why
difficult
apply
clinic
from
point
view
method
rather
than
design
vaccine.
also
describes
some
not
yet
vaccines
and,
considering
this
conjunction
those
currently
purpose,
predicts
their
prospects
future
application.
Язык: Английский