Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications

Gels, Год журнала: 2025, Номер 11(2), С. 126 - 126

Опубликована: Фев. 9, 2025

Peripheral nerve injuries pose a significant clinical challenge due to the complex biological processes involved in repair and their limited regenerative capacity. Despite advances surgical techniques, conventional treatments, such as autografts, are faced with limitations like donor site morbidity inconsistent functional outcomes. As such, there is growing interest new, novel, innovative strategies enhance regeneration. Tissue engineering/regenerative medicine its use of biomaterials an emerging example strategy. Within realm tissue engineering, functionalized hydrogels have gained considerable attention ability mimic extracellular matrix, support cell growth differentiation, even deliver bioactive molecules that can promote repair. These be engineered incorporate factors, peptides, stem cells, creating conducive microenvironment for cellular axonal Recent advancements materials well biology led development sophisticated hydrogel systems, not only provide structural support, but also actively modulate inflammation, recruitment, stimulate neurogenesis. This review explores potential peripheral repair, highlighting composition, biofunctionalization, mechanisms action. A comprehensive analysis preclinical studies provides insights into efficacy these promoting growth, neuronal survival, regeneration, and, ultimately, recovery. Thus, this aims illuminate promise transformative tool field bridging gap between complexity feasibility.

Язык: Английский

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Selinexor’s Immunomodulatory Impact in Advancing Multiple Myeloma Treatment

Cells, Год журнала: 2025, Номер 14(6), С. 430 - 430

Опубликована: Март 13, 2025

Despite the major advancements in repertoire for multiple myeloma (MM) treatment, this disease remains a chronically progressive plasma cell malignancy. Drug resistance and high relapse rates complicate extended treatment strategies. However, tumor microenvironment (TME) MM is decisive success of therapy or relapse. Aiming to improve outcome relapsed refractory patients, Selinexor has entered drug arsenal through implementation novel therapeutic approach by selectively inhibiting nuclear export receptor Exportin-1 (XPO1). leads inactivation cancer-related proteins induces apoptosis disrupting nucleocytoplasmic flow cells. While cytotoxic neoplastic cells, Selinexor’s immunomodulatory impact on TME currently being investigated. The aim review was elucidate capacity influence interaction network from an immunological perspective. Deciphering complex interplay highly plastic immune cells provides contribution molecular–biological exploration initiation progression MM. Unraveling targets evaluating advanced immunotherapeutic regimens implementing will shape future directions immune-oncotherapy

Язык: Английский

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Immunomodulatory All-Natural Kelp Decellularized Scaffold Prepared Using Deep Eutectic Solvent with Angiogenic Properties for Accelerating Diabetic Wound Healing

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Excessive oxidative stress, chronic inflammation, and impaired vascularization are the main barriers to diabetic wound repair. A decellularized extracellular matrix (dECM) with a native ECM structure is promising biomaterial candidate for healing. However, traditional decellularization process (reagents) can diminish structural stability, mechanical properties, bioactive components of dECM. To address these issues, we developed an intrinsically kelp scaffold (Im-Gly2) using natural gentle deep eutectic solvents (DES) accelerating Im-Gly2 had stable porous 3D (80.7 μm) suitable which could support cell growth, proliferation, migration. Due retention fucoidan, polyphenols (735.3 μg/g), flavonoids, demonstrated intrinsic antioxidant immunomodulatory effects. It effectively reduced reactive oxygen species (ROS) production in RAW264.7 macrophages promoted their differentiation into M2 phenotype. Notably, tube formation through paracrine mechanisms by inducing expression transforming proliferative cytokines from macrophage. In vivo, accelerated healing wounds alleviating angiogenesis, granulation tissue formation, collagen deposition, re-epithelialization. Taken together, our study provides novel strategy fabricating dECM without cross-linking exogenous substances

Язык: Английский

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Nanocomposite hydrogel with multiple metal ions coupling for effective treatment of bacteria infected wound via cascade catalysis and tissue regeneration

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161783 - 161783

Опубликована: Март 1, 2025

Язык: Английский

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3D-printed bioceramic scaffolds for bone defect repair: bone aging and immune regulation

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 28, 2025

The management of bone defects, particularly in aging populations, remains a major clinical challenge. immune microenvironment plays an important role the repair defects and favorable environment can effectively promote defects. However, is closely associated with chronic low-grade systemic inflammation, which adversely affects healing. Persistent inflammation critically regulates through all stages. This review explores potential 3D-printed bioceramic scaffolds defect repair, focusing on their capacity to modulate counteract effects aging. not only provide structural support for regeneration but also serve as effective carriers anti-osteoporosis drugs, offering novel therapeutic strategy treating osteoporotic By regulating improving response, may significantly enhance context age-related degeneration. approach underscores advanced biomaterials addressing dual challenges dysregulation, promising avenues development treatments elderly. We hope concepts discussed this could offer strategies suggest future optimization scaffolds.

Язык: Английский

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Zwitterionic pH-Responsive Polyurethane Nanoparticles with Cinnamaldehyde and Aggregation-Induced Emission Photosensitizers for Photodynamic Therapy of Diabetic Infected Wounds

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

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Ultrasound-Activated Sonothermal-Catalytic Synergistic Therapy via Asymmetric Electron Distribution for Bacterial Wound Infections

Biomaterials, Год журнала: 2025, Номер unknown, С. 123338 - 123338

Опубликована: Апрель 1, 2025

Язык: Английский

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Geranium essential oil downregulates virulence genes and mitigates MRSA wound infections through a multifunctional hydrogel

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143197 - 143197

Опубликована: Апрель 17, 2025

Язык: Английский

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Novel asymmetrical double-layer structural adhesive hydrogels with synergetic neuroprotection and angiogenesis effect for diabetic wound healing

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 159081 - 159081

Опубликована: Дек. 1, 2024

Язык: Английский

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